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公开(公告)号：US20210122830A1
公开(公告)日：2021-04-29
申请号：US17003442
申请日：2020-08-26
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Edward N. VAN DEN BRINK , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD, D.M.Sc. , David SATIJN , Jan VAN DE WINKEL , Paul PARREN
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20210107985A1
公开(公告)日：2021-04-15
申请号：US16883333
申请日：2020-05-26
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Catharina Emanuele Gerarda HAVENITH , Paul PARREN , Jan G. J. VAN DE WINKEL , Denise Leah WILLIAMS , Jørgen PETERSEN , Ole BAADSGAARD
IPC: C07K16/28 , G01N33/68 , A61K39/395 , A61K45/06 , A61N5/06 , C07K16/42 , C07K16/46 , G01N33/574 , G01N33/569
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US20180298106A1
公开(公告)日：2018-10-18
申请号：US15909540
申请日：2018-03-01
Applicant: GENMAB A/S
Inventor： Michel DE WEERS , Tim WALSETH , Jan VAN DE WINKEL , Tom VINK , Paul PARREN
IPC: C07K16/28 , G01N33/573 , A61K45/06 , A61K39/395
Abstract: Isolated monoclonal antibodies which bind to human CD38 and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US20180201693A1
公开(公告)日：2018-07-19
申请号：US15742803
申请日：2016-07-01
Applicant: GENMAB A/S
Inventor： Richard G. HIBBERT , Aran F. LABRIJN , Arnout F. GERRITSEN , Janine SCHUURMAN , Paul PARREN
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K16/2863 , C07K16/2887 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/526 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
Abstract: Bispecific and multispecific antibodies having differentially modified light chains, that allows for isolation of the bispecific or multispecific antibodies based on a differential affinity towards an affinity reagent.
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公开(公告)号：US20170369594A1
公开(公告)日：2017-12-28
申请号：US15599395
申请日：2017-05-18
Applicant: GENMAB A/S
Inventor： Joost J. NEIJSSEN , Joyce I. MEESTERS , Bart DE GOEIJ , Aran Frank LABRIJN , Paul PARREN , Janine SCHUURMAN
Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20170327597A1
公开(公告)日：2017-11-16
申请号：US15536143
申请日：2015-12-18
Applicant: GENMAB A/S
Inventor： Aran F. LABRIJN , Joyce I. MEESTERS , Janine SCHUURMAN , Paul PARREN , Anthony ARMSTRONG , Matthew BUNCE , Mark CHIU , Thomas NESSPOR , Adam ZWOLAK
CPC classification number: C07K16/462 , A61K49/0008 , C07K16/00 , C07K16/2809 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/64 , C07K2317/73
Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.
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公开(公告)号：US20170240640A1
公开(公告)日：2017-08-24
申请号：US15420824
申请日：2017-01-31
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Catharina Emanuele Gerarda HAVENITH , Paul PARREN , Jan G. J. VAN DE WINKEL , Denise Leah WILLIAMS , Jørgen PETERSEN , Ole BAADSGAARD
IPC: C07K16/28 , G01N33/569 , C07K16/42 , G01N33/68 , A61K45/06 , A61K39/395
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US20160067349A1
公开(公告)日：2016-03-10
申请号：US14854613
申请日：2015-09-15
Applicant: GENMAB A/S
Inventor： David SATIJN , Sandra VERPLOEGEN , Wim BLEEKER , Steen LISBY , Jan VAN DE WINKEL , Patrick VAN BERKEL , Paul PARREN
CPC classification number: A61K47/48561 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/30 , C07K16/36 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic methods for using the antibodies and antibody drug conjugates.
Abstract translation: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物共轭物的药物组合物，以及使用抗体和抗体药物偶联物的治疗和诊断方法。
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公开(公告)号：US20150259424A1
公开(公告)日：2015-09-17
申请号：US14592558
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Catharina Emanuele Gerarda HAVENITH , Paul PARREN , Jan G.J. VAN DE WINKEL , Denise Leah WILLIAMS , Jørgen PETERSEN , Ole BAADSGAARD
IPC: C07K16/28 , A61K45/06 , A61N5/06 , C07K16/46 , G01N33/574 , A61K39/395 , C07K16/42
CPC classification number: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20150231235A1
公开(公告)日：2015-08-20
申请号：US14566279
申请日：2014-12-10
Applicant: GENMAB A/S
Inventor： Jan VAN DE WINKEL , Paul PARREN , Yvo GRAUS , Judith OPRINS , Michel DE WEERS , Martine VAN VUGT , Ole BAADSGAARD, D.M.Sc. , Steen LISBY
IPC: A61K39/395 , A61K31/4439 , A61K31/198 , A61K31/573 , A61K31/69
Abstract: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.
Abstract translation: 本发明涉及使用包含结合CD38的抗体，皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
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