公开(公告)号：US06613872B1

公开(公告)日：2003-09-02

申请号：US09159812

申请日：1998-09-23

申请人： Jiangchun Xu ,  Davin C. Dillon

发明人： Jiangchun Xu ,  Davin C. Dillon

IPC分类号： C07K500

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  C07K14/705 ,  C07K2319/00

摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

公开(公告)号：US06579973B1

公开(公告)日：2003-06-17

申请号：US09433826

申请日：1999-11-03

申请人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker

发明人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker

IPC分类号： C07K100

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portion thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US06432707B1

公开(公告)日：2002-08-13

申请号：US09602877

申请日：2000-06-22

申请人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon

发明人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon

IPC分类号： C12H502

CPC分类号： C07K14/82 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2317/21 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于癌症的治疗和诊断的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US06387697B1

公开(公告)日：2002-05-14

申请号：US09222575

申请日：1998-12-28

申请人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

发明人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

IPC分类号： C12N500

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.

摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明的化合物包括含有至少一部分乳腺肿瘤抗原的多肽。 提供包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸，以及用于制备本发明多肽的多核苷酸。 本发明的多肽可用于产生可用于诊断和监测乳腺癌的抗体。

公开(公告)号：US06365348B1

公开(公告)日：2002-04-02

申请号：US09118554

申请日：1998-07-17

申请人： Steven G. Reed ,  Jiangchun Xu

发明人： Steven G. Reed ,  Jiangchun Xu

IPC分类号： C12Q168

CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K39/00

摘要： Compounds and methods for the diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.

摘要翻译： 提供了用于诊断乳腺癌的化合物和方法。 本发明化合物包括含有至少一部分乳腺肿瘤蛋白质的多肽。 本发明的多肽可用于产生可用于诊断和监测乳腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。