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公开(公告)号：US06395278B1
公开(公告)日：2002-05-28
申请号：US09352616
申请日：1999-07-13
IPC分类号： A61K3848
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5156 , C07K14/705 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。
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2.发明授权Compositions for the treatment and diagnosis of breast cancer and methods for their use 失效用于乳腺癌治疗和诊断的组合及其使用方法公开(公告)号：US06573368B2
公开(公告)日：2003-06-03
申请号：US09339338
申请日：1999-06-23
IPC分类号： C12N500
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.
摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明的化合物包括含有至少一部分乳腺肿瘤抗原的多肽。 提供包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸，以及用于制备本发明多肽的多核苷酸。 本发明的多肽可用于产生可用于诊断和监测乳腺癌的抗体。
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3.发明授权Compositions for treatment and diagnosis of breast cancer and methods for their use 失效用于乳腺癌的治疗和诊断的组合及其使用方法公开(公告)号：US06518237B1
公开(公告)日：2003-02-11
申请号：US09389681
申请日：1999-09-02
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/118
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。
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公开(公告)号：US06329505B1
公开(公告)日：2001-12-11
申请号：US09439313
申请日：1999-11-12
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Jiang Yuqiu , Steve G. Reed , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Jiang Yuqiu , Steve G. Reed , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day
IPC分类号： C07K1400
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5156 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022 , C12N2760/16222
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。
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5.发明授权Compositions for the treatment and diagnosis of breast cancer and methods for their use 失效用于乳腺癌治疗和诊断的组合及其使用方法公开(公告)号：US06579973B1
公开(公告)日：2003-06-17
申请号：US09433826
申请日：1999-11-03
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portion thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。
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6.发明授权Compositions for treatment and diagnosis of breast cancer and methods for their use 失效用于乳腺癌的治疗和诊断的组合及其使用方法公开(公告)号：US06387697B1
公开(公告)日：2002-05-14
申请号：US09222575
申请日：1998-12-28
IPC分类号： C12N500
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.
摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明的化合物包括含有至少一部分乳腺肿瘤抗原的多肽。 提供包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸，以及用于制备本发明多肽的多核苷酸。 本发明的多肽可用于产生可用于诊断和监测乳腺癌的抗体。
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7.发明授权Compositions for the treatment and diagnosis of breast cancer and methods for their use 失效用于乳腺癌治疗和诊断的组合及其使用方法公开(公告)号：US06590076B1
公开(公告)日：2003-07-08
申请号：US09285480
申请日：1999-04-02
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/118
摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.
摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明的化合物包括含有至少一部分乳腺肿瘤抗原的多肽。 提供包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸，以及用于制备本发明多肽的多核苷酸。 本发明的多肽可用于产生可用于诊断和监测乳腺癌的抗体。
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公开(公告)号：US07074898B2
公开(公告)日：2006-07-11
申请号：US10010940
申请日：2001-12-05
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5156 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022 , C12N2760/16222
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US06620922B1
公开(公告)日：2003-09-16
申请号：US09636215
申请日：2000-08-09
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5156 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16222
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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10.发明授权Compositions for the treatment and diagnosis of breast cancer and methods for their use 失效用于乳腺癌治疗和诊断的组合及其使用方法公开(公告)号：US06844325B2
公开(公告)日：2005-01-18
申请号：US09551621
申请日：2000-04-17
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , C07K14/47 , C12N9/00 , C12Q1/68 , A01N43/04 , A61K31/70 , C07H21/04 , C07H21/02 , C12N15/74
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/4748 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158 , Y10S530/806 , Y10S530/828
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。
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