公开(公告)号：US06844325B2

公开(公告)日：2005-01-18

申请号：US09551621

申请日：2000-04-17

Applicant: Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker

Inventor： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker

IPC: A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N9/00 ,  C12Q1/68 ,  A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  C07H21/02 ,  C12N15/74

CPC classification number: C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S530/806 ,  Y10S530/828

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Abstract translation: 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US06800746B2

公开(公告)日：2004-10-05

申请号：US09759143

申请日：2001-01-12

Applicant: Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

Inventor： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC: C12Q168

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US06512094B1

公开(公告)日：2003-01-28

申请号：US09593793

申请日：2000-06-13

Applicant: Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

Inventor： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC: C07K100

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06329505B1

公开(公告)日：2001-12-11

申请号：US09439313

申请日：1999-11-12

Applicant: Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Jiang Yuqiu ,  Steve G. Reed ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day

Inventor： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Jiang Yuqiu ,  Steve G. Reed ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day

IPC: C07K1400

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022 ,  C12N2760/16222

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

Abstract translation: 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US20080219988A1

公开(公告)日：2008-09-11

申请号：US11928383

申请日：2007-10-30

Applicant: Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick

Inventor： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick

IPC: A61K39/395 ,  C07K7/06 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C07K16/00 ,  A61K35/12 ,  A61P35/00 ,  A61K38/16 ,  G01N33/574 ,  C07K14/00 ,  C12N5/00 ,  A61K38/08 ,  A61K31/7052

CPC classification number: C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US06699664B1

公开(公告)日：2004-03-02

申请号：US09667857

申请日：2000-09-20

Applicant: Jennifer L. Mitcham ,  Gordon E. King ,  Paul A. Algate ,  Steven P. Fling ,  Marc W. Retter ,  Gary R. Fanger ,  Steven G. Reed ,  Thomas S. Vedvick ,  Darrick Carter

Inventor： Jennifer L. Mitcham ,  Gordon E. King ,  Paul A. Algate ,  Steven P. Fling ,  Marc W. Retter ,  Gary R. Fanger ,  Steven G. Reed ,  Thomas S. Vedvick ,  Darrick Carter

IPC: C12Q168

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.

Abstract translation: 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。

公开(公告)号：US06680197B2

公开(公告)日：2004-01-20

申请号：US09834759

申请日：2001-04-13

Applicant: Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler ,  Robert A. Henderson

Inventor： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler ,  Robert A. Henderson

IPC: C12N508

CPC classification number: C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

Abstract translation: 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。

公开(公告)号：US06630305B1

公开(公告)日：2003-10-07

申请号：US09685166

申请日：2000-10-10

Applicant: Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

Inventor： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC: C12Q168

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/53 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US06573368B2

公开(公告)日：2003-06-03

申请号：US09339338

申请日：1999-06-23

Applicant: Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

Inventor： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

IPC: C12N500

CPC classification number: C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118

Abstract: Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.

Abstract translation: 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明的化合物包括含有至少一部分乳腺肿瘤抗原的多肽。 提供包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸，以及用于制备本发明多肽的多核苷酸。 本发明的多肽可用于产生可用于诊断和监测乳腺癌的抗体。

公开(公告)号：US06518237B1

公开(公告)日：2003-02-11

申请号：US09389681

申请日：1999-09-02

Applicant: Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

Inventor： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

IPC: C12Q168

CPC classification number: C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/118

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Abstract translation: 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。