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公开(公告)号：US06972290B2
公开(公告)日：2005-12-06
申请号：US10347529
申请日：2003-01-17
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31/4965 , A61K31/497 , A61P29/00 , A61P43/00 , C07D241/04 , C07D261/14 , C07D295/185 , C07D307/52 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/495
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
摘要翻译： 本发明涉及可用作抗炎剂的酰基哌嗪衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗人类炎性疾病的方法。
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公开(公告)号：US06686364B2
公开(公告)日：2004-02-03
申请号：US09924893
申请日：2001-08-07
申请人： Brad O. Buckman , David D. Davey , William J. Guilford , Michael M. Morrissey , Howard P. Ng , Gary B. Phillips , Shung C. Wu , Wei Xu
发明人： Brad O. Buckman , David D. Davey , William J. Guilford , Michael M. Morrissey , Howard P. Ng , Gary B. Phillips , Shung C. Wu , Wei Xu
IPC分类号： A61K314965
CPC分类号： C07D213/69
摘要： This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及可用作抗凝剂的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US06541476B1
公开(公告)日：2003-04-01
申请号：US09713606
申请日：2000-11-14
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31496
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): wherein R1a, R2, R3, R4, R5, and R6 are described herein. These derivatives are useful anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
摘要翻译： 本发明涉及例如下式（Ia）的酰基哌嗪衍生物：其中R1a，R2，R3，R4，R5和R6如本文所述。 这些衍生物是有用的抗炎剂。 本发明还涉及含有衍生物的药物组合物，以及使用该衍生物治疗人类炎性疾病的方法。
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公开(公告)号：US06479485B2
公开(公告)日：2002-11-12
申请号：US09924413
申请日：2001-08-07
申请人： Brad O. Buckman , David D. Davey , William J. Guilford , Michael M. Morrissey , Howard P. Ng , Gary B. Phillips , Shung C. Wu , Wei Xu
发明人： Brad O. Buckman , David D. Davey , William J. Guilford , Michael M. Morrissey , Howard P. Ng , Gary B. Phillips , Shung C. Wu , Wei Xu
IPC分类号： A61K31534
CPC分类号： C07D213/69 , C07C257/18 , C07C275/42 , C07D213/74 , C07D213/79 , C07D213/81 , C07D213/82 , C07D231/12 , C07D233/56 , C07D239/52 , C07D241/18 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14
摘要： This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
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公开(公告)号：US06350746B1
公开(公告)日：2002-02-26
申请号：US09457457
申请日：1999-12-08
申请人： Brad O. Buckman , David D. Davey , William J. Guilford , Michael M. Morrissey , Howard P. Ng , Gary B. Phillips , Shung C. Wu , Wei Xu
发明人： Brad O. Buckman , David D. Davey , William J. Guilford , Michael M. Morrissey , Howard P. Ng , Gary B. Phillips , Shung C. Wu , Wei Xu
IPC分类号： C07D40112
CPC分类号： C07D213/69 , C07C257/18 , C07C275/42 , C07D213/74 , C07D213/79 , C07D213/81 , C07D213/82 , C07D231/12 , C07D233/56 , C07D239/52 , C07D241/18 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14
摘要： This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及可用作抗凝剂的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US06306884B1
公开(公告)日：2001-10-23
申请号：US09436399
申请日：1999-11-08
申请人： Brad O. Buckman , David D. Davey , William J. Guilford , Michael M. Morrissey , Howard P. Ng , Gary B. Phillips , Shung C. Wu , Wei Xu
发明人： Brad O. Buckman , David D. Davey , William J. Guilford , Michael M. Morrissey , Howard P. Ng , Gary B. Phillips , Shung C. Wu , Wei Xu
IPC分类号： A61K3154
CPC分类号： C07D213/69 , C07C257/18 , C07C275/42 , C07D213/74 , C07D213/79 , C07D213/81 , C07D213/82 , C07D231/12 , C07D233/56 , C07D239/52 , C07D241/18 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14
摘要： This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及可用作抗凝剂的苯甲脒衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US06221886B1
公开(公告)日：2001-04-24
申请号：US09481987
申请日：2000-01-11
IPC分类号： A61K3144
CPC分类号： C07D401/12
摘要： This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及由用作抗凝剂的无环或环状硫代衍生物取代的单环N-杂环。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US6004985A
公开(公告)日：1999-12-21
申请号：US731128
申请日：1996-10-09
IPC分类号： A61K31/4439 , A61K31/506 , A61P7/02 , C07D401/12 , C07D401/14 , A61K31/44
CPC分类号： C07D401/12
摘要： This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
摘要翻译： 本发明涉及由用作抗凝剂的无环或环状硫代衍生物取代的单环N-杂环。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗以血栓形成活性为特征的疾病状态的方法。
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公开(公告)号：US5994375A
公开(公告)日：1999-11-30
申请号：US599834
申请日：1996-02-12
IPC分类号： C07D213/60 , A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61P7/00 , A61P7/02 , C07C43/20 , C07C257/18 , C07D401/12 , C07D401/14 , C07D401/10
CPC分类号： C07D401/12
摘要： This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
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