公开(公告)号：US20110190797A1

公开(公告)日：2011-08-04

申请号：US13084880

申请日：2011-04-12

申请人： John Fulkerson ,  David A. Ferrera ,  Andrew Cragg

发明人： John Fulkerson ,  David A. Ferrera ,  Andrew Cragg

IPC分类号： A61B17/22

CPC分类号： A61B17/3207 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00845 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2017/22082 ,  A61F2/013 ,  A61F2/82 ,  A61F2250/0059 ,  A61M29/02 ,  A61M2025/1095 ,  A61M2025/1097

摘要： An acute stroke recanalization system and processes include catheter-based improved reconstrainable or tethered neurological devices which are deliverable through highly constricted and tortuous vessels, crossing the zone associated with subject thrombi/emboli, where deployment impacts, addresses or bridges the embolus, compacting the same into luminal walls which enables perfusion and lysis of the embolus, while the improved neurological medical device itself remains contiguous with the delivery system acting as a filter, basket or stand alone stenting mechanism, depending on the status of the embolus and other therapeutic aspects of the treatment being offered for consideration.

摘要翻译： 急性中风再通系统和过程包括基于导管的改善的可重建或系留的神经系统装置，其可通过高度收缩和曲折的血管交付，穿过与受试者血栓/栓塞相关的区域，其中部署影响，解决或桥接栓塞，压制相同 进入能够灌注和溶解栓塞的腔壁，而改进的神经医学装置本身与作为过滤器，篮子或独立支架机构的输送系统保持连续，这取决于栓塞的状态和其他治疗方面 治疗被提供考虑。

公开(公告)号：US20110117133A1

公开(公告)日：2011-05-19

申请号：US12618037

申请日：2009-11-13

申请人： Avigdor Shafferman ,  Anat Zvi ,  Naomi Ariel ,  John Fulkerson ,  Roaggai Sun ,  Rosemary Chang ,  Jerald C. Sadoff

发明人： Avigdor Shafferman ,  Anat Zvi ,  Naomi Ariel ,  John Fulkerson ,  Roaggai Sun ,  Rosemary Chang ,  Jerald C. Sadoff

IPC分类号： A61K39/04 ,  A61P31/06 ,  A61P37/04

CPC分类号： A61K39/04 ,  A61K2039/522 ,  A61K2039/53 ,  C07K14/35

摘要： A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.

摘要翻译： 提供了一种针对结核分枝杆菌（Mtb）的疫苗。 该疫苗包含一种重组的基于卡介苗（BCG）亚基的疫苗，其中一种或多种Mtb抗原和一种或多种Mtb复苏或再激活抗原过表达，其中至少部分DosR调节子被上调 。 疫苗在Mtb前后暴露于Mtb感染时可以防止活动性Mtb感染，从而防止由于潜在的Mtb感染复发引起的疾病症状。

公开(公告)号：US20110117124A1

公开(公告)日：2011-05-19

申请号：US12675535

申请日：2008-08-29

申请人： Jerald C. Sadoff ,  John Fulkerson ,  Mohamad Fakruddin-Jamiluddin ,  Michele R. Stone ,  Ravi Anatha

发明人： Jerald C. Sadoff ,  John Fulkerson ,  Mohamad Fakruddin-Jamiluddin ,  Michele R. Stone ,  Ravi Anatha

IPC分类号： A61K39/04 ,  C12N15/63 ,  A61K39/002 ,  A61K35/76 ,  C12N15/86 ,  A61P31/06 ,  A61P33/06 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K39/04 ,  A61K39/12 ,  A61K39/145 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55516 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/14043 ,  C12N2710/14143 ,  C12N2760/16134 ,  C12N2840/203 ,  Y02A50/386 ,  Y02A50/394 ,  Y02A50/412 ,  Y02A50/466

摘要： Viral-based vectors are genetically engineered to express inhibitors of the anti-viral immune system (e.g. inhibitors of the type I interferon response) in order to enhance transgene expression. The transgenes may encode antigens or other therapeutic agents.

摘要翻译： 为了增强转基因表达，基于病毒的载体被遗传工程化以表达抗病毒免疫系统的抑制剂（例如I型干扰素应答的抑制剂）。 转基因可以编码抗原或其他治疗剂。

公开(公告)号：US07935141B2

公开(公告)日：2011-05-03

申请号：US11505185

申请日：2006-08-16

申请人： Michael Randall ,  John Fulkerson

发明人： Michael Randall ,  John Fulkerson

IPC分类号： A61F2/06

CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2002/9517

摘要： A delivery system for deploying a medical device, such as a stent, at increasing deployment speed is described. The system comprises a catheter comprising a catheter shaft, a retractable sheath slidably mounted on the catheter shaft, and the device in a compressed state sandwiched between the shaft and sheath. A control handle is included with a housing and knobs for a user to apply a rotary or other force to retract the sheath. The sheath is attached to a slider that is mounted on a slide rod and attached to a drive belt. A take up pulley is provided in the housing and connected to the belt input knob, so that the pulley turns when the knob is turned. The belt is attached to the pulley so that the drive is wound onto the rotating pulley. As the belt winds upon the pulley, the overall outside diameter of the pulley increases, thereby increasing the deployment speed.

摘要翻译： 描述了以增加的展开速度部署诸如支架的医疗装置的递送系统。 该系统包括导管，其包括导管轴，可滑动地安装在导管轴上的可缩回护套，以及夹在轴和护套之间的压缩状态的装置。 控制手柄包括有壳体和旋钮，用于使用者施加旋转或其它力以缩回护套。 护套附接到安装在滑杆上并连接到传动带上的滑块。 收紧皮带轮设置在外壳中并连接到皮带输入旋钮，以便当旋钮转动时滑轮转动。 皮带安装在皮带轮上，使驱动器缠绕在旋转皮带轮上。 当皮带缠绕在皮带轮上时，滑轮的整个外径增加，从而增加了展开速度。

公开(公告)号：US20090072043A1

公开(公告)日：2009-03-19

申请号：US12191782

申请日：2008-08-14

申请人： Ilia KONDRATAYEV ,  John Fulkerson ,  Igor Kamenkov ,  Vladimir A. Paramygin

发明人： Ilia KONDRATAYEV ,  John Fulkerson ,  Igor Kamenkov ,  Vladimir A. Paramygin

IPC分类号： B05B17/04

CPC分类号： C02F1/34

摘要： A cavitation nozzle includes a hydro-acoustic oscillator, an orifice, and a conical diffuser. The conical diffuser includes a first zone for diffusing a liquid jet, a second zone comprising two or more shear chambers for creating additional cavitation bubbles by creating rotational flow in the chamber, and a third zone which has a diameter larger than the shear chambers or the first zone.

摘要翻译： 空化喷嘴包括水声振荡器，孔口和锥形扩散器。 锥形扩散器包括用于扩散液体射流的第一区域，包括两个或更多个剪切室的第二区域，用于通过在腔室中产生旋转流动而产生额外的空化气泡;以及第三区域，其具有大于剪切室的直径或 第一区。

公开(公告)号：US06808529B2

公开(公告)日：2004-10-26

申请号：US09827062

申请日：2001-04-05

申请人： John Fulkerson

发明人： John Fulkerson

IPC分类号： A61M2900

CPC分类号： A61F2/95 ,  A61F2002/9517

摘要： An apparatus and method for intraluminal delivery and deployment of an expandable prosthesis at a site within a body canal is provided. The apparatus comprises an elongated sleeve and an outer shaft disposed within the elongated sleeve and movable relative to the sleeve. A securing member is disposed on a distal area of the outer shaft. The expandable prosthesis is housed within a distal area of the elongated sleeve, and a distal area of the prosthesis is secured to the outer shaft by the securing member. The stent is deployed by displacing the sleeve in a proximal direction relative to the outer shaft to expose the stent and by releasing the stent from the securing member. If necessary, the stent can be repositioned prior to releasing the stent from the securing member.

摘要翻译： 提供了一种用于在体腔内的部位进行腔内递送和展开可扩张假体的装置和方法。 该装置包括细长套筒和设置在细长套筒内并可相对于套筒移动的外轴。 固定构件设置在外轴的远侧区域上。 可扩张假体容纳在细长套筒的远侧区域内，并且假体的远侧区域通过固定构件固定到外轴。 支架通过相对于外轴在近端方向移位套筒来展开，以暴露支架并通过从固定构件释放支架。 如果需要，可以在从固定构件释放支架之前重新定位支架。