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    THROMBUS MANAGEMENT SYSTEM
    3.
    发明申请
    THROMBUS MANAGEMENT SYSTEM 审中-公开
    THROMBUS管理系统

    公开(公告)号：US20120041460A1

    公开(公告)日：2012-02-16

    申请号：US13281348

    申请日：2011-10-25

    申请人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

    发明人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

    IPC分类号： A61B17/22

    CPC分类号： A61F2/82 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00309 ,  A61B2017/00867 ,  A61B2017/22001 ,  A61B2017/22034 ,  A61B2017/22039 ,  A61B2017/22079 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/2215 ,  A61B2017/32096 ,  A61B2090/3966 ,  A61F2/91 ,  A61F2/915 ,  A61M25/0074 ,  A61M2025/0042

    摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.

    摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，渐进式治疗可以包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解，浸渍和/或去除。

    FLOW RESTORATION METHODS
    4.
    发明申请
    FLOW RESTORATION METHODS 审中-公开
    流程恢复方法

    公开(公告)号：US20120016406A1

    公开(公告)日：2012-01-19

    申请号：US13245190

    申请日：2011-09-26

    申请人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

    发明人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

    IPC分类号： A61M29/00

    CPC分类号： A61F2/82 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00309 ,  A61B2017/00867 ,  A61B2017/22001 ,  A61B2017/22034 ,  A61B2017/22039 ,  A61B2017/22079 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/2215 ,  A61B2017/32096 ,  A61B2090/3966 ,  A61F2/91 ,  A61F2/915 ,  A61M25/0074 ,  A61M2025/0042

    摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.

    摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，逐步治疗可以包括三步逐步治疗过程，其包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解和浸渍。 逐步或模块化的治疗可以由一个或多个治疗装置的系统或试剂盒提供。

    Microcoil vaso-occlusive device with multi-axis secondary configuration
    6.
    发明授权
    Microcoil vaso-occlusive device with multi-axis secondary configuration 有权

    公开(公告)号：US07033374B2

    公开(公告)日：2006-04-25

    申请号：US10043947

    申请日：2002-01-11

    申请人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

    发明人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

    IPC分类号： A61M29/00

    CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00526 ,  A61B2017/00867

    摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration-comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral. In all embodiments, the device, in its secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site (i.e., aneurysm) in which it is to be deployed. Thus, confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow. Furthermore, the secondary configuration is not conducive to “coin stacking,” thereby minimizing the compaction experienced.

    Clot retrieval device
    7.
    发明授权
    Clot retrieval device 有权

    公开(公告)号：US07008434B2

    公开(公告)日：2006-03-07

    申请号：US10754660

    申请日：2004-01-08

    申请人： Daniel R. Kurz ,  David A. Ferrera

    发明人： Daniel R. Kurz ,  David A. Ferrera

    IPC分类号： A61B17/22

    CPC分类号： A61B17/22031 ,  A61B17/221 ,  A61B2017/00867 ,  A61B2017/00871 ,  A61B2017/22034 ,  A61B2017/2217

    摘要： The shape memory clot retrieval device can be placed in the vasculature of a patient for retrieving and removing distal clots. The clot retrieval device has an elongated catheter member that can be inserted in the vasculature, with one or more clot retrieval members on the elongated catheter member that are movable between an initial compressed configuration in which the clot retrieval device is inserted into the vasculature and an expanded configuration extending outwardly from the elongated catheter member to trap and hold clots within the vessel. The clot retrieval device typically can be introduced to the desired treatment site in the vasculature through a guiding catheter.

    Variable stiffness heating catheter
    8.
    发明授权
    Variable stiffness heating catheter 失效
    可变刚度加热导管

    公开(公告)号：US06887235B2

    公开(公告)日：2005-05-03

    申请号：US09813119

    申请日：2001-03-19

    申请人： Michael J. O'Connor ,  David A. Ferrera ,  Matthew Connors

    发明人： Michael J. O'Connor ,  David A. Ferrera ,  Matthew Connors

    IPC分类号： A61B18/24 ,  A61M25/00 ,  A61B18/04

    CPC分类号： A61M25/00 ,  A61B18/24 ,  A61M25/0051 ,  A61M25/0053 ,  A61M2025/0064

    摘要： The variable stiffness heating catheter includes a heating catheter shaft including at least one electrically conductive member, a reinforcing tube with apertures formed around the surface of the reinforcing tube, and at least one coaxial outer layer of a polymer, metal, or both for providing desired variations in stiffness along at least a portion of the length of the shaft. The apertures can be formed as axial or helical slits in the surface of the reinforcing tube, and the reinforcing tube can also be formed to be tapered at the point where the apertures are formed in the reinforcing tube to provide a heating catheter that is torqueable and pushable at the proximal end, yet soft and flexible at the distal end.

    摘要翻译： 可变刚度加热导管包括加热导管轴，其包括至少一个导电构件，具有围绕加强管的表面形成的孔的加强管，以及聚合物，金属或两者的至少一个同轴外层，用于提供期望的 沿轴长度的至少一部分的刚度变化。 孔可以形成为加强管的表面中的轴向或螺旋狭缝，并且加强管也可以形成为在加强管中形成孔的点成锥形，以提供可扭转的加热导管， 在近端可推，但在远端柔软柔韧。

    Intravascular flow modifier and reinforcement device
    10.
    发明授权
    Intravascular flow modifier and reinforcement device 失效
    血管内流量调节器和加强装置

    公开(公告)号：US06656218B1

    公开(公告)日：2003-12-02

    申请号：US09590793

    申请日：2000-06-08

    申请人： Andrew J. Denardo ,  David A. Ferrera ,  Peter Wilson ,  Lok A. Lei

    发明人： Andrew J. Denardo ,  David A. Ferrera ,  Peter Wilson ,  Lok A. Lei

    IPC分类号： A61F206

    CPC分类号： A61F2/01 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/12172 ,  A61B17/1219 ,  A61F2/07 ,  A61F2/88 ,  A61F2/885 ,  A61F2/90 ,  A61F2002/016 ,  A61F2002/072 ,  A61F2210/0014 ,  A61F2230/0013 ,  A61F2230/0071 ,  A61F2230/0091 ,  A61F2250/0036 ,  A61F2250/0037 ,  B21F45/008

    摘要： An intravascular flow modifier and vascular reinforcement for treatment of aneurysms is formed of one or more loops of wire of resilient material formed into a series of transverse loops and longitudinal connecting sections to configure an essentially cylindrical reinforcement device that still allows, if desired, access to the neck of an aneurysm for insertion of embolic coils and the like. The proximal and distal regions of the sinusoidal loops may be more tightly coiled than the intermediate regions of the loops, or may have a larger diameter than the intermediate regions. The intravascular flow modifier and vascular reinforcement device can be provided with an outer covering that can be formed as a fiber, and can be woven, or can be formed as a ribbon wound about the intravascular flow modifier and vascular reinforcement device. The wire of resilient material can also be coated with a hydrophilic material. One or more round or oval intermediate loops extending radially outward may also be provided. An apparatus for removing clots may also be formed from one or more loops of wire of resilient material in a hollow conical shape non-detachably joined to a deployment device, to trap and hold clots within a vessel.

    摘要翻译： 用于治疗动脉瘤的血管内流动改善剂和血管增强剂由形成为一系列横向环和纵向连接部分的一个或多个弹性材料线的一个或多个环形成，以构造基本上圆柱形的加强装置，如果需要，其还允许进入 用于插入栓塞线圈的动脉瘤的颈部等。 正弦曲线的近端和远端区域可以比环路的中间区域更紧密地盘绕，或者可以具有比中间区域更大的直径。 血管内流动改性剂和血管加强装置可以设置有可以形成为纤维的外覆盖层，并且可以被编织，或者可以形成为卷绕在血管内流动改性剂和血管加强装置周围的带状物。 弹性材料的丝线也可以用亲水材料涂覆。 还可以设置一个或多个径向向外延伸的圆形或椭圆形中间环。 用于除去凝块的装置也可以由一个或多个中空圆锥形的弹性材料线的一个或多个环形成，其不可拆卸地连接到展开装置，以将血块捕获并保持在容器内。