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120 条记录 (耗时 0.022 秒)

    Veterinary dispenser delivering beneficial agent by gas power generated in situ
    62.
    发明授权
    Veterinary dispenser delivering beneficial agent by gas power generated in situ 失效
    兽医师通过原位生成的天然气动力来提供有益的药剂

    公开(公告)号：US4675174A

    公开(公告)日：1987-06-23

    申请号：US766372

    申请日：1985-08-16

    申请人： James B. Eckenhoff

    发明人： James B. Eckenhoff

    IPC分类号： A23K1/16 ,  A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/54 ,  B01J7/02 ,  A61M31/00

    CPC分类号： B01J7/02 ,  A61K9/0004

    摘要： A dispensing system is disclosed for delivering a beneficial agent. The dispensing system comprises (1) a housing defining an internal space, (2) a gas-generating composition in the space, (3) a dense member in the space, (4) a composition comprising a beneficial agent and a non-toxic heat responsive carrier in the space, and (5) a passageway in the housing for delivering the beneficial agent for the dispensing system.

    摘要翻译： 公开了用于递送有益剂的分配系统。 分配系统包括（1）限定内部空间的壳体，（2）空间中的气体发生组合物，（3）空间中的致密构件，（4）包含有益剂和无毒物质的组合物 在空间中的热响应载体，以及（5）壳体中的用于输送分配系统的有益剂的通道。

    Fluid imbibing pump with self-regulating skin patch
    63.
    发明授权
    Fluid imbibing pump with self-regulating skin patch 失效
    流体吸入泵具有自我调节皮肤贴片

    公开(公告)号：US4655766A

    公开(公告)日：1987-04-07

    申请号：US853262

    申请日：1986-04-17

    申请人： Felix Theeuwes ,  James B. Eckenhoff

    发明人： Felix Theeuwes ,  James B. Eckenhoff

    IPC分类号： A61K9/00 ,  A61K9/70

    CPC分类号： A61K9/703 ,  A61K9/0004 ,  A61K9/7084

    摘要： A medical device comprising a fluid imbibing, self-regulating, skin patch drug delivery system is disclosed which includes a fluid imbibing, preferably osmotic, pump comprising a reservoir for a drug or, drug formulation or other fluid to be dispensed to the skin, 10 at least one wall of the reservoir comprising a fluid permeable membrane which is permeable to an external activating fluid. The external fluid is imbibed through the membrane at a predetermined rate thereby causing the drug to be pumped through one or more passages provided in the reservoir structure and 15 into contact with the skin. The device includes an impermeable exterior wall member which covers and extends outwardly from the fluid imbibing pump terminating in an edge portion adapted to be secured, as by adhesion, to the skin. The exterior wall member, when attached to the skin surface, defines the area of skin which is available for distribution of the drug formulation pumped from the reservoir which is large enough, at the lowest anticipated skin permeation, to deliver the drug to the body at the rate at which it is discharged from the fluid imbibing pump in the preferred embodiments the fluid permeable membrane is a semipermeable membrane, impermeable to the drug or drug formulation.

    摘要翻译： 公开了一种包括流体吸收的自调节皮肤贴片药物递送系统的医疗装置，其包括流体吸收，优选渗透泵，其包括用于药物或药物制剂或将被分配到皮肤的其它流体的储存器10 储存器的至少一个壁包括可渗透外部活化流体的流体可渗透膜。 外部流体以预定的速率吸入膜中，从而使得药物被泵送通过设置在储存器结构和15中的一个或多个通道与皮肤接触。 该装置包括不透水的外壁构件，其从流体吸收泵向外覆盖并向外延伸，终止于边缘部分，其适于通过粘附固定到皮肤上。 外壁构件在附着于皮肤表面时限定了皮肤的面积，其可用于分配从储存器抽出的药物制剂，该药剂配制剂足够大，以最低的预期皮肤渗透率将药物递送至身体 在优选实施例中，其从流体吸入泵排出的速率，流体可渗透膜是对药物或药物制剂不可渗透的半透膜。

    Multiple fluid pulse dispenser
    65.
    发明授权
    Multiple fluid pulse dispenser 失效
    多流体脉冲分配器

    公开(公告)号：US4522622A

    公开(公告)日：1985-06-11

    申请号：US452522

    申请日：1982-12-23

    申请人： John R. Peery ,  James B. Eckenhoff

    发明人： John R. Peery ,  James B. Eckenhoff

    IPC分类号： A61M5/142 ,  A61M5/28 ,  A61M37/00 ,  B65D35/22

    CPC分类号： A61M5/14248 ,  A61M37/00 ,  A61M5/1424 ,  A61M5/282

    摘要： A multiple fluid pulse dispenser comprising a plurality of interconnected fluid reservoirs defined by mating, oppositely directed concavities at least one of which mating concavity is formed from an invertable, preferrably permanently deformable blister. The reservoirs are in fluid communication with an outlet through which the contents of the reservoirs may be dispensed. A preferred embodiment permits fluid to flow through a reservoir after it has been discharged to allow random activation of the individual reservoirs.

    摘要翻译： 多个液体脉冲分配器，其包括多个相互连接的流体储存器，该多个相互连接的流体储存器由配合的相对指向的凹部限定，其中至少一个配合凹部由可反转的优选永久变形的泡罩形成。 储存器与出口流体连通，通过该出口可以分配储存器的内容物。 优选实施例允许流体在其被排出之后流过储存器以允许各个储存器的随机活化。

    Osmotically driven fluid dispenser
    66.
    发明授权
    Osmotically driven fluid dispenser 失效
    渗透驱动的流体分配器

    公开(公告)号：US4320758A

    公开(公告)日：1982-03-23

    申请号：US214182

    申请日：1980-12-08

    申请人： James B. Eckenhoff ,  Johan H. Geerke ,  Felix A. Landrau

    发明人： James B. Eckenhoff ,  Johan H. Geerke ,  Felix A. Landrau

    IPC分类号： B01J4/04 ,  A61M7/00

    CPC分类号： B01D61/002 ,  A61K9/0004 ,  A61M31/002 ,  A61M5/14526 ,  A61M5/14593 ,  A61M5/148 ,  B01D63/00 ,  B01D71/26 ,  A61M2005/14513

    摘要： An improved version of an osmotically driven mini-osmotic pump that is used to administer drug solutions. The basic components of the improved pump are: an inner flexible bag that holds the drug solution; a plug having a recessed inner end that seals the bag opening; a solution filling/discharge port through the plug; a cup-shaped, thermo-formed sleeve that fits partly about the bag and is made from a dispersion of an osmotically effective solute in a water soluble, theroplastic polymer vehicle; a shape-retaining, semipermeable membrane that encapulates the bag-sleeve subassembly; and a flow moderator that is received through the filling/discharge port in the plug.

    摘要翻译： 改进版本的渗透驱动的微型渗透泵，用于管理药物溶液。 改进泵的基本部件是：保持药液的内部柔性袋; 具有密封袋开口的内凹端的插头; 通过插头的解决方案的灌装/排放口; 一个杯状的热成型套筒，其部分地围绕袋子配合，并且由渗透性有效的溶质在水溶性的塑料聚合物载体中的分散体制成; 包封袋套组件的形状保持性半透膜; 以及通过塞子中的填充/排出口容纳的流动调节剂。

    Self-contained suction pump
    67.
    发明授权
    Self-contained suction pump 失效
    自给式抽水泵

    公开(公告)号：US4299222A

    公开(公告)日：1981-11-10

    申请号：US110376

    申请日：1980-01-08

    申请人： James B. Eckenhoff

    发明人： James B. Eckenhoff

    IPC分类号： A61K9/00 ,  F04B43/10 ,  A61M1/00

    CPC分类号： F04B43/10 ,  A61K9/0004

    摘要： A small suction pump that may be implanted in test animals to draw biological fluid samples is disclosed. The pump, before it is activated, consists of an outer, impermeable expansible housing, an inner, expanded elastomeric fluid collection container housed within the housing, a port extending from the container lumen through the housing, a rigid semipermeable partition between the housing and inner container, and a water-imbibing composition interposed between the housing and the partition. The pump is activated by charging water between the partition and container. Such charging of water forces the container to collapse. In operation water is drawn through the partition by the water imbibing composition thereby permitting the container to expand and suck fluid via the port.

    摘要翻译： 公开了可以植入测试动物以吸引生物流体样品的小抽吸泵。 泵在其被启动之前由外部不可渗透的可膨胀壳体，容纳在壳体内部的内部膨胀弹性体流体收集容器，从容器腔延伸通过壳体的端口，在壳体和内部之间的刚性半透膜分隔件 容器和插入在壳体和隔板之间的吸水组合物。 通过在分隔件和容器之间加水来激活泵。 这种水的充电迫使容器崩溃。 在操作中，通过吸水组合物将水分分隔开，从而允许容器通过端口膨胀和吸收流体。

    Method and apparatus for delivering first agent followed by second agent
    70.
    发明授权
    Method and apparatus for delivering first agent followed by second agent 失效
    用于递送第一代理，后跟第二代理的方法和装置

    公开(公告)号：US5840074A

    公开(公告)日：1998-11-24

    申请号：US852248

    申请日：1992-06-02

    申请人： Atul Devdatt Ayer ,  James B. Eckenhoff ,  Jeremy C. Wright ,  Anthony L. Kuczynski

    发明人： Atul Devdatt Ayer ,  James B. Eckenhoff ,  Jeremy C. Wright ,  Anthony L. Kuczynski

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0068 ,  A61K9/0004

    摘要： The invention provides a dispensing device (10) comprising a loading dose (32) (first agent delivery device) for short-term and continuous delivery of agent, retained together with a long-term dispensing device (12) (second agent delivery device) capable of long-term and continuous delivery of agent. The combination of first and second agent delivery device provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (A) a loading dose chamber (30) and retaining device (16) retaining a loading dose (32) (short-term delivery device) for rapid and continuous delivery of agent to the environment of use; and (B) a long-term dispensing device (12) (long-term delivery device) comprising a semipermeable wall (14) which surrounds and defines an internal lumen (20), a driving source (22) (expansion device) in the lumen for expanding and occupying an increased volume of the lumen, a beneficial agent (24) in the lumen that provides a dispensable formulation to the environment of use, and an exit (28) in the device for delivery of the beneficial agent to the environment of use over time. A densifier (26) and/or a moveable barrier device (34) may also be included in the lumen of the long-term dispensing device.

    摘要翻译： PCT No.PCT / US90 / 07598 Sec。 371日期：1992年6月2日 102（e）日期1992年6月2日PCT 1990年12月21日PCT PCT。 出版物WO91 / 10423 日期1991年7月10日本发明提供一种分配装置（10），其包括与长期分配装置（12）保持在一起的用于短期和连续输送药剂的负荷剂量（32）（第一药剂输送装置） 第二代理递送设备），能够长期和连续地递送代理。 第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂随时间递送到使用环境中。 随后快速递送有益药剂，其次是持续和长期的药剂输送。 在优选实施例中，装置包括（A）负载剂量室（30）和保持装置（16），保持装置（16）保持负载剂量（32）（短期输送装置），用于将药剂快速和连续地递送到使用环境中; 和（B）包括围绕并限定内腔（20）的半透壁（14）的长期分配装置（12）（长期输送装置），其中 用于扩张和占据管腔体积增加的内腔，在内腔中的有益剂（24），其向使用环境提供可分配的配方，以及用于将有益剂递送至环境的装置中的出口（28） 随着时间的推移使用。 致密器（26）和/或可移动屏障装置（34）也可以包括在长期分配装置的内腔中。