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61.发明授权Cascade polymer complexes, process for producing the same and pharmaceuticals containing the same 失效级联聚合物复合物，其制备方法和含有它的药物
公开(公告)号：US6057419A
公开(公告)日：2000-05-02
申请号：US77773
申请日：1998-06-04
申请人： Heribert Schmitt-Willich , Johannes Platzek , Bernd Raduchel , Hanns-Joachim Weinmann , Wolfgang Ebert , Bernd Misselwitz , Andreas Muhler , Thomas Frenzel
发明人： Heribert Schmitt-Willich , Johannes Platzek , Bernd Raduchel , Hanns-Joachim Weinmann , Wolfgang Ebert , Bernd Misselwitz , Andreas Muhler , Thomas Frenzel
IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K49/12 , A61K51/00 , C07D295/108 , C07F5/00 , C08G73/06 , C08L79/00
CPC分类号： A61K49/085 , A61K49/04 , A61K49/124 , Y10S514/836
摘要： Cascade polymer complexes that contain a) complexing ligands of general formula (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, and that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.64 holds true for the product of the multiplicities and that at least one of cascade reproduction units X, Y, Z, W stands for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-teraazacyclotetradecane reproduction unit, b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well as d) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.
摘要翻译： PCT No.PCT / EP96 / 05315 Sec。 371日期：1998年6月4日 102（e）日期1998年6月4日PCT 1996年11月29日PCT PCT。 出版物WO97 / 23245 日期1997年7月3日包含a）通式（I）的络合配体的级联聚合物络合物，其中A代表碱基多重性a的含氮级联核，X和Y彼此独立地代表直接 连接或再现多重性的级联再现单位x或y，z和W彼此独立地代表再现倍数z或w的级联再现单位，K表示络合剂的基团，a表示数字2 至12，x，y，z和w彼此独立地代表数字1至4，条件是至少两个再现单位不同，并且16
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公开(公告)号：US6045776A
公开(公告)日：2000-04-04
申请号：US982381
申请日：1997-12-02
IPC分类号： A61K49/08 , C07D257/02 , C07D499/00 , A61B5/055
CPC分类号： A61K49/106 , A61K49/085 , A61K49/10 , A61K49/124 , A61K49/14 , A61K49/143 , A61K49/146 , C07D257/02 , C07D499/00 , Y10S514/836
摘要： The invention relates to a process for the production of metal-complex carboxylic acid amides, characterized in that a metal-complex carboxylic acid mixture that consists of the metal-complex carboxylic acid and at least one solubilizing substance in dimethyl sulfoxide (DMSO) is pretreated with a dehydrating reagent, optionally with the addition of a coupling adjuvant, and is then reacted with an amine of general formula IA(NH.sub.2).sub.n (I),in whichA stands for the radical of a natural or synthetic amine, andn stands for numbers 1 to 100.
摘要翻译： 本发明涉及一种生产金属络合物羧酸酰胺的方法，其特征在于将由金属络合物羧酸和至少一种在二甲基亚砜（DMSO）中的增溶物质组成的金属络合物羧酸混合物进行预处理 与脱水试剂，任选地加入偶联佐剂，然后与通式IA（NH 2）n（I）的胺反应，其中A代表天然或合成胺的基团，n代表 数字1到100。
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63.发明授权Macrocyclic polymer complexing agents, their complexes, process for their production and pharmaceutical agents containing these compounds 失效大环聚合物络合剂，它们的络合物，其制备方法和含有这些化合物的药剂
公开(公告)号：US5876698A
公开(公告)日：1999-03-02
申请号：US881269
申请日：1992-05-11
申请人： Heribert Schmitt-Willich , Johannes Platzek , Heinz Gries , Gabriele Schuhmann-Giampieri , Thomas Frenzel
发明人： Heribert Schmitt-Willich , Johannes Platzek , Heinz Gries , Gabriele Schuhmann-Giampieri , Thomas Frenzel
IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K51/00 , A61K51/06 , C08G69/10 , C08G69/48 , G01N31/00 , G01N33/48
CPC分类号： A61K51/065 , A61K49/085 , A61K49/106 , A61K49/146 , A61K2123/00
摘要： Polymeric compounds of general formula I(M).sub.n A (I)in whichM stands for the radical of a macrocyclic complexing agent,A stands for a backbone molecule, which shows a deficit of n amino groups, n hydroxy groups or n carboxy groups,n stands for the numbers 1 to 400, characterized in thatM, independent of one another, stands for complexing agents of general formula IA ##STR1## in which all variables are defined herein.
摘要翻译： 通式I（M）nA（I）的聚合化合物，其中M代表大环络合剂的基团，A代表主链分子，其表现出n个氨基，n个羟基或n个羧基的缺陷， n代表数字1至400，其特征在于，M彼此独立地代表通式IA（IA）的络合剂，其中所有变量在本文中定义。
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64.发明授权Cascade polymer complexes, process for their production and pharamceutical agents containing said complexes 失效级联聚合物复合物，其生产方法和含有所述复合物的药物
公开(公告)号：US5820849A
公开(公告)日：1998-10-13
申请号：US674844
申请日：1996-07-03
IPC分类号： A61K49/00 , A61K20060101 , A61K49/04 , A61K49/08 , A61K49/12 , A61P43/00 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07D487/08 , C07F5/00 , C07K5/04 , C07K14/00 , C08G69/00 , C08G73/02 , C08G85/00 , C08L101/00 , A61B5/055 , A61K51/04
CPC分类号： C07D487/08 , A61K49/04 , A61K49/085 , A61K49/124 , A61K51/065 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07K14/001 , Y10S424/16
摘要： Cascade polymer complexes that contain a) complexing ligands of general formula I A-{X-�Y-(Z- .sub.Z).sub.y !.sub.x }.sub.a (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different and that for the product of the multiplicities, 16
摘要翻译： 含有a）通式IA- {X- [Y-（Z-
Z）y] x} a（I）的络合配体的级联聚合物络合物，其中A代表含氮级联核 基本多重性a，X和Y彼此独立地代表再现多重性x或y，Z和W的直接键合或级联再现单元，彼此独立地代表再现倍数z的级联再现单位 或w，K表示络合剂的基团，代表数字2至12，x，y，z和w彼此独立地代表数字1至4，条件是至少两个再现单位不同 并且对于多重性的乘积，16 -
65.发明授权
公开(公告)号：US5759518A
公开(公告)日：1998-06-02
申请号：US663233
申请日：1996-10-03
IPC分类号： A61K49/00 , A61K49/12 , A61K49/18 , C08G18/60 , C08G69/00 , C08G73/00 , C08G73/02 , C08G73/06 , C08G83/00 , C08G85/00 , A61B5/055 , A61K49/04 , A61K51/04 , C07F5/00
CPC分类号： A61K49/124 , A61K51/04 , B82Y5/00 , C08G73/0206 , C08G73/06 , C08G83/00
摘要： The invention relates to new metal complexes of dendrimeric macromolecules that contain 8 to 64 ions of an element of atomic numbers 21-129, 39, 42-44, or 57-83 and a polymeric, complexing ligand of formula I A--(X).sub.b (I) in which A, X and b have different meanings, agents that contain these compounds as well as the use of the latter in diagnosis. The invention further relates to a process for the production of the complexes and agents.
摘要翻译： PCT No.PCT / EP94 / 04016 Sec。 371日期：1996年10月3日 102（e）日期1996年10月3日PCT 1994年12月2日PCT公布。 公开号WO95 / 17451 日期：1995年6月29日本发明涉及含有原子序数21-129,39,42-44或57-83的元素的8至64个离子的树枝状大分子的新金属络合物和式IA的聚合物络合配体 - （X）b（I）其中A，X和b具有不同的含义，含有这些化合物的试剂以及后者在诊断中的用途。 本发明进一步涉及生产复合物和试剂的方法。
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66.发明授权Substituted complexing agents, complexes, and complex salts, processes for their production, and pharmaceuticals containing same 失效取代的络合剂，络合物和络合盐，其制备方法和含有它们的药物
公开(公告)号：US5693309A
公开(公告)日：1997-12-02
申请号：US462213
申请日：1995-06-05
申请人： Julius Deutsch , Heinz Gries , Erich Klieger , Ulrich Niedballa , Franz-Josef Renneke , Jurgen Conrad , Wolfgang Muetzel , Heribert Schmitt-Willich
发明人： Julius Deutsch , Heinz Gries , Erich Klieger , Ulrich Niedballa , Franz-Josef Renneke , Jurgen Conrad , Wolfgang Muetzel , Heribert Schmitt-Willich
IPC分类号： A61K49/04 , C07C243/34 , A61B5/055
CPC分类号： C07C243/00 , C07C243/34 , Y10S514/836 , Y10T436/24
摘要： 1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4, X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-39, 42-44, 49 or 57-83, R.sup.1 and R.sup.2, being different, mean in each case a hydrogen atom or a straight-chain, branched, saturated or unsaturated C.sub.0 -C.sub.20 -alkylene group, this alkylene group exhibiting at the end either a second molecule of general Formula I.sub.A or I.sub.B ##STR2## a functional group, or, linked by way of this functional group, a bio- or macromolecule, are valuable diagnostic and therapeutic media,
摘要翻译： 1.通式I的化合物（I）其中n和m在各种情况下均指数字0,1,2,3和4，X表示氢原子和/或其元素的金属离子当量 原子序数21-29,31,32,37-39,42-44,49或57-83，R1和R2不同，在每种情况下是指氢原子或直链，支链，饱和或不饱和的C0 -C亚烷基，该亚烷基末端表示通式IA或IB的第二分子（IA），（IB）官能团，或通过该官能团连接， 生物或大分子，是有价值的诊断和治疗媒介，
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67.发明授权Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them 失效级联聚合物结合的络合化合物，其络合物和共轭物，其生产方法和含有它们的药剂
公开(公告)号：US5650136A
公开(公告)日：1997-07-22
申请号：US353390
申请日：1994-12-02
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/12 , A61K51/00 , A61K51/06 , C07F5/00 , C07G99/00 , C08G69/48 , C08G73/00 , C08G73/02 , C08G83/00 , C08G85/00 , C09K3/00
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
摘要翻译： 含有复合物形成配体的级联聚合物，任选地是原子序数21-29,39,42,44或57-83的元素的至少五个离子，以及如果需要的话，无机和/或有机碱的阳离子， 氨基酸或氨基酸酰胺，是诊断和治疗的有价值的复合化合物和复合物。
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68.发明授权Cascade polymer bound chelating compounds, their chelates and conjugates, processes for their production, and pharmaceutical agents containing them 失效级联聚合物结合的螯合化合物，它们的螯合物和共轭物，其生产方法和含有它们的药剂
公开(公告)号：US5364614A
公开(公告)日：1994-11-15
申请号：US617077
申请日：1990-11-21
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/12 , A61K51/00 , A61K51/06 , C07F5/00 , C07G99/00 , C08G69/48 , C08G73/00 , C08G73/02 , C08G83/00 , C08G85/00 , C09K3/00 , C07D225/00 , G01N31/00
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
摘要翻译： 含有复合物形成配体的级联聚合物，任选地是原子序数21-29,39,42,44或57-83的元素的至少五个离子，以及如果需要的话，无机和/或有机碱的阳离子， 氨基酸或氨基酸酰胺，是诊断和治疗的有价值的复合化合物和复合物。
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