公开(公告)号：US07956320B2

公开(公告)日：2011-06-07

申请号：US12301306

申请日：2006-05-18

申请人： Shinichi Yamaguchi

发明人： Shinichi Yamaguchi

IPC分类号： H01J49/26

CPC分类号： G01N27/62

摘要： A main peak list is created with the data obtained by an MSn analysis (S1), the difference between the mass-to-charge ratio of each product ion listed on this main peak list and that of the precursor ion is calculated (S2), and an auxiliary peak list for forming a virtual peak corresponding to the mass-to-charge ratio difference is created (S3). On the same graph, an MSn spectrum data is created so that each peak listed on the main peak list and each peak listed on the auxiliary peak list are drawn with different display colors (S4), and the MSn spectrum is displayed on the display screen (S5). Consequently, an MSn analysis result for a plurality of precursor ions with different mass-to-charge ratios becomes easy to be compared. In particular, it is possible to easily and visually determine whether or not a fragment having the same mass-to-charge ratio desorbed by a dissociation exists.

摘要翻译： 利用MSn分析获得的数据（S1）创建主峰列表，计算出在该主峰列表上列出的各产物离子的质荷比与前体离子的质荷比之差（S2） 并且创建用于形成与质荷比差相对应的虚拟峰的辅助峰列表（S3）。 在同一曲线图上，创建MSn频谱数据，使得主峰列表上列出的每个峰和辅助峰列表上列出的每个峰以不同的显示颜色绘制（S4），并且MSn频谱显示在显示屏幕上 （S5）。 因此，容易比较具有不同质荷比的多个前体离子的MSn分析结果。 特别地，可以容易地和目测地确定是否存在具有通过解离解吸的相同质荷比的片段。

公开(公告)号：US07872223B2

公开(公告)日：2011-01-18

申请号：US12296360

申请日：2006-04-07

申请人： Shinichi Yamaguchi

发明人： Shinichi Yamaguchi

IPC分类号： H01J49/04

CPC分类号： H01J49/0004

摘要： A laser light is linearly delivered onto the sample 4. The ions generated from the irradiated area are collected, mass-separated in the mass separator 27, and detected by the detector 28. A mass analysis is repeated while moving the sample stage 3 by a predetermined step width in the x-axis direction so that the one-dimensional mass spectrum information of the sample 4 at a certain rotational position is obtained. Additionally, while the sample 4 is rotated by a predetermined angle, the same measurement is repeated for the entire perimeter, so that the one-dimensional mass spectrum information at each rotational position is obtained. Based on the data obtained in this manner, a reconstruction computational processing is performed by the CT method to reconstruct the two-dimensional distribution image for a substance having a certain mass for example and the image is displayed on the display 35.

摘要翻译： 将激光线性地传送到样品4上。从照射区域产生的离子在质量分离器27中被收集，质量分离，并由检测器28检测。重复质量分析，同时将样品台3移动 使x轴方向的规定的台阶宽度成为一定的旋转位置的样品4的一维质谱信息。 此外，当样品4旋转预定角度时，对于整个周边重复相同的测量，从而获得每个旋转位置处的一维质谱信息。 基于以这种方式获得的数据，通过CT方法进行重建计算处理，以重构用于具有一定质量的物质的二维分布图像，并且图像显示在显示器35上。

公开(公告)号：US20100324833A1

公开(公告)日：2010-12-23

申请号：US12739108

申请日：2007-10-22

申请人： Shinichi Yamaguchi

发明人： Shinichi Yamaguchi

IPC分类号： G06F19/00

CPC分类号： G01N27/62 ,  G06F19/703 ,  H01J49/0036 ,  H01J49/004

摘要： A product ion spectrum is created on the basis of MS2 analysis data respectively obtained for a parent compound and a metabolite (S1 and S2). Additionally, a neutral loss spectrum, in which the mass of each product ion is replaced with a mass difference between the mass of the product ion and that of a precursor ion, is created (S3). Then, a common peak having the same mass in both the parent compound and the metabolite is extracted (S4), and a complementary peak appearing at a position corresponding to the difference between the mass of the common peak and that of the precursor ion is extracted (S5); the complementary peak corresponding to a common peak located on the product ion spectrum appears on the neutral loss spectrum, while the complementary peak corresponding to a common peak located on the neutral loss spectrum appears on the product ion spectrum. In the process of displaying the four spectrums in an integrated form, different display colors are assigned to the common peak, complementary peak and other peaks so that the different peaks can be easily distinguished (S6 to S9).

摘要翻译： 基于分别为母体化合物和代谢物获得的MS2分析数据产生产物离子谱（S1和S2）。 另外，产生中性损失谱，其中每个产物离子的质量被产物离子的质量与前体离子的质量之间的质量差代替（S3）。 然后，提取在母体化合物和代谢物中具有相同质量的共同峰（S4），并且提取出现在对应于共峰的质量与前体离子的质量之间的位置处的互补峰 （S5）; 对应于位于产物离子光谱上的共同峰的互补峰出现在中性损失光谱上，而对应于位于中性损失光谱上的共同峰的互补峰出现在产物离子光谱上。 在以集成形式显示四个光谱的过程中，将不同的显示颜色分配给共同的峰值，互补峰值和其他峰值，使得可以容易地区分不同的峰值（S6至S9）。

公开(公告)号：US20100277026A1

公开(公告)日：2010-11-04

申请号：US12810526

申请日：2008-12-01

申请人： Shinichi Yamaguchi ,  Hisashi Otsuka ,  Haruyuki Hasegawa

发明人： Shinichi Yamaguchi ,  Hisashi Otsuka ,  Haruyuki Hasegawa

IPC分类号： H02K1/27 ,  H02K1/16

CPC分类号： H02K21/16 ,  H02K1/146 ,  H02K1/276 ,  H02K29/03 ,  H02K2201/06

摘要： A rotary electric machine comprising a rotor (30A) including a plurality of permanent magnets having magnetic poles and a stator (20A) including a plurality of tooth sections each having a front end portion which faces the rotor, wherein the rotor (30A) has a skew structure having a change section in which boundaries between the magnetic poles change with respect to a rotation axis direction, and the front end portion of each of the plurality of tooth sections of the stator (20A) has an auxiliary slot (24A) which is selectively formed in an extending manner at one portion of the front end portion in the rotation axis direction such that substantially a center of the auxiliary slot in the rotation axis direction is opposed to a center of the change section in the rotation axis direction, and no auxiliary slot is formed at portions located on extensions of the auxiliary slot in the rotation axis direction.

摘要翻译： 一种旋转电机，其特征在于，包括具有多个具有磁极的永磁体的转子（30A）和具有多个齿部的定子（20A），所述多个齿部具有与所述转子对置的前端部，所述转子 具有变化部分的倾斜结构，其中磁极之间的边界相对于旋转轴线方向变化，并且定子（20A）的多个齿部分中的每一个的前端部分具有辅助槽（24A），该辅助槽 在前端部的旋转轴方向的一部分上以延伸方式选择性地形成，使得辅助槽在旋转轴线方向上的大致中心与转动轴方向的中心相对，而不 辅助槽形成在辅助槽在旋转轴线方向的延伸部上的部分。

公开(公告)号：US20100239773A1

公开(公告)日：2010-09-23

申请号：US12310605

申请日：2007-09-06

申请人： Shinichi Yamaguchi ,  Masao Kurosaki ,  Yasuto Goto ,  Manabu Kumagai ,  Kensuke Mizuno ,  Takumi Kozaki

发明人： Shinichi Yamaguchi ,  Masao Kurosaki ,  Yasuto Goto ,  Manabu Kumagai ,  Kensuke Mizuno ,  Takumi Kozaki

IPC分类号： C09D5/08 ,  B05D3/02

CPC分类号： C23C22/58 ,  C23C22/08 ,  C23C22/34 ,  C23C22/36 ,  C23C2222/10

摘要： An aqueous treating solution for an Sn-based plated steel sheet, comprising (A) an organic material, (B) a water-soluble chromium compound, (C) a water-dispersible silica, and water, wherein the organic material (A) is at least one member selected from an oxy-acid with the ratio of hydroxyl group/carboxyl group in one molecule being from 3/1 to 10/1, its lactone form and an oxide derivative thereof, the water-soluble chromium compound (B) does not contain hexavalent chromium, and pH is from 0.7 to 6.0.

摘要翻译： （A）有机材料，（B）水溶性铬化合物，（C）水分散性二氧化硅和水，其中所述有机材料（A） 是选自一分子中的羟基/羧基的比例为3/1〜10/1的氧酸中的至少一种，其内酯型及其氧化物衍生物，水溶性铬化合物（B ）不含六价铬，pH值为0.7〜6.0。

公开(公告)号：US20100148061A1

公开(公告)日：2010-06-17

申请号：US12600375

申请日：2007-05-22

申请人： Shinichi Yamaguchi ,  Masaru Nishiguchi

发明人： Shinichi Yamaguchi ,  Masaru Nishiguchi

IPC分类号： H01J49/40

CPC分类号： H01J49/408

摘要： A basic ion optical system (2) in which the temporal focusing of ions is ensured includes a plurality of sector-shaped electrodes (11, 12, 13, and 14), an ion injection slit (15), and an ion ejection slit (16), which are placed on the same plane. A plurality of basic ion optical systems (2) are placed in such a manner as to be mutually separated at predetermined intervals in the direction approximately orthogonal to their planes. The ion ejection slit (16) of the lower-stage basic ion optical system (2) and the ion injection slit (15) of the next-stage basic ion optical system (2) are connected to each other via another basic ion optical system (3) in which the temporal focusing of the ions is ensured. Accordingly, the flight distance can be elongated while assuredly achieving the temporal focusing of the ions as an entire ion optical system (1), and a three-dimensional space can be efficiently utilized to compactify the ion optical system (1).

摘要翻译： 确保离子的时间聚焦的基本离子光学系统（2）包括多个扇形电极（11,12,13,14），离子注入狭缝（15）和离子喷射狭缝（ 16），它们放置在同一平面上。 多个基本离子光学系统（2）以与其平面大致正交的方向以预定间隔相互分离的方式放置。 下一级碱性离子光学系统（2）的离子喷射狭缝（16）和下一级碱性离子光学系统（2）的离子注入狭缝（15）通过另一种碱性离子光学系统 （3），其中确保离子的时间聚焦。 因此，飞行距离可以延长，同时可靠地实现作为整个离子光学系统（1）的离子的时间聚焦，并且可以有效地利用三维空间来压缩离子光学系统（1）。

公开(公告)号：US07399960B2

公开(公告)日：2008-07-15

申请号：US11333214

申请日：2006-01-18

申请人： Shinichi Yamaguchi

发明人： Shinichi Yamaguchi

IPC分类号： B01D59/44

CPC分类号： H01J49/408

摘要： A time of flight mass spectrometer according to the present invention includes: a) an ion source at which an ion starts flying; b) an energizer for giving a predetermined amount of energy to the ion to let the ion start flying from the ion source; c) an ion guide for forming a time-focusing flight path on which the ion flies once or repeatedly; d) a detector for detecting the ion after flying the flight path; e) an analysis controller for giving different amounts of energy to ions of the same kind using the energizer, and for measuring the values of the flight time of the ions from the ion source to the detector for the amount of energy; and f) a mass calculator for calculating or estimating the mass to charge ratio of the ion based on the difference in the values of the flight time of the ions. Since the flight time of ions on the time-focusing flight path does not depend on their kinetic energy, the difference in the flight time of an ion having two different amounts of energy gives the estimation of the mass to charge ratio of the ion. Thus, a mass spectrometry of an ion for a wide range of mass to charge ratio can be made by simply performing two measurements on the same sample. This greatly reduces the time and labor of mass analysis, and a wide range of mass spectrum can be obtained on a scarce sample on which many-time measurements are impossible.

公开(公告)号：US20080121793A1

公开(公告)日：2008-05-29

申请号：US11718365

申请日：2005-10-26

申请人： Shinichi Yamaguchi ,  Yusuke Inohana

发明人： Shinichi Yamaguchi ,  Yusuke Inohana

IPC分类号： H01J49/00

CPC分类号： H01J49/0081 ,  H01J49/0027

摘要： In a mass analysis of a sample, candidate compositions Y of a fragment ion produced by a dissociating operation are deduced from the mass of that fragment ion (Steps S6 to S9). If the number of the candidates Y is larger than a predetermined value (“No” in Step S10), the repetition counter of the dissociating operation is increased by one and the mass analysis of the fragment ion is performed again. If the number of the candidates is equal to or smaller than the predetermined value, the difference between the masses of the fragment ions before and after each mass-analyzing stage is calculated (Step S11). From this mass difference, the candidates Z of the desorption ion at each stage is deduced (Step S12). These candidates Z and Y are used to narrow down the candidate composition formulae X deduced from the mass of the precursor ion (Step S13). If the number of the candidates has decreased to one or become equal to or smaller than a predetermined value, the result is displayed (Steps S14 and S15). Thus reducing the number of the candidates to the lowest possible value, the present method provides the user with useful information for analyzing the molecular structure and/or composition of a sample having a large molecular weight.

摘要翻译： 在样品的质量分析中，从该片段离子的质量推导出通过解离操作产生的片段离子的候选组合物Y（步骤S6〜S9）。 如果候选Y的数量大于预定值（步骤S10中为“否”），则解离操作的重复计数器增加1，并再次执行碎片离子的质量分析。 如果候选人数等于或小于预定值，则计算每个质量分析阶段之前和之后的碎片离子的质量差（步骤S11）。 从该质量差，推导出各阶段的解吸离子的候选物Z（步骤S12）。 这些候选物Z和Y用于缩小从前体离子的质量推导的候选组成式X（步骤S13）。 如果候选人数减少到一个或变得等于或小于预定值，则显示结果（步骤S14和S15）。 因此，本方法为用户提供了用于分析具有大分子量的样品的分子结构和/或组成的有用信息。

公开(公告)号：US07361889B2

公开(公告)日：2008-04-22

申请号：US11390109

申请日：2006-03-28

申请人： Shinichi Yamaguchi

发明人： Shinichi Yamaguchi

IPC分类号： H01J49/40

CPC分类号： H01J49/0036 ,  H01J49/408

摘要： The present invention relates to a time of flight mass spectrometer (TOFMS) having a flight space in which ions to be analyzed repeatedly fly in a loop orbit or reciprocal path. In an example of the present invention, the TOFMS carries out two rounds of measurement for one sample under two conditions differing in the effective flight distance of the ions to create two flight time spectrums. The data processor of the TOFMS compares the central points of the peaks in the two spectrums to identify peaks that have resulted from the same kind of ion (Step S3). If any peak is found to be unidentifiable (“No” in Step S4), the data processor examines the similarity of the peak shapes (e.g. half-value width) to identify peaks that have resulted from the same kind of ion (Step S5). After the correspondence of all the peaks have been determined, the data processor calculates the approximate mass to charge ratio of each ion from the difference in flight time (Step S6) and determines the number of turns of the ion based on the approximation (Step S7). Finally, it calculates the exact mass to charge ratio, using the number of turns and the flight time (Step S8). Thus, even if the sample contains many components and the spectrums accordingly have many peaks mixed together, the TOFMS can identify all the peaks.

摘要翻译： 本发明涉及具有飞行空间的飞行时间质谱仪（TOFMS），其中待分析的离子重复地以循环轨道或往复路径飞行。 在本发明的一个实例中，TOFMS在两个条件下对一个样品进行两轮测量，这两个条件不同于离子的有效飞行距离，以产生两个飞行时间谱。 TOFMS的数据处理器比较两个光谱中的峰的中心点，以识别由相同种类的离子产生的峰（步骤S 3）。 如果发现任何峰值无法识别（步骤S 4中为“否”），则数据处理器检查峰形状（例如半值宽度）的相似性，以识别由相同种类的离子产生的峰（步骤S 5）。 在确定了所有峰的对应关系之后，数据处理器根据飞行时间差计算每个离子的近似质荷比（步骤S6），并根据近似值确定离子的匝数（步骤 S 7）。 最后，使用匝数和飞行时间来计算确切的充电比例（步骤S 8）。 因此，即使样品含有许多组分，并且光谱相应地具有多个混合在一起的峰，则TOFMS可以鉴定所有峰。

公开(公告)号：US20070228270A1

公开(公告)日：2007-10-04

申请号：US11730621

申请日：2007-04-03

申请人： Shinichi Yamaguchi

发明人： Shinichi Yamaguchi

IPC分类号： H01J49/00

CPC分类号： H01J49/004 ,  H01J49/027 ,  H01J49/408

摘要： The present invention provides a single set of mass spectrometer capable of selectively performing the following two modes of analyses according to the purpose of analysis: the first mass spectrometry mode in which the analysis can be repeated at short intervals of time; and the second mass spectrometry mode in which the analysis can be performed with high mass resolution and high accuracy. In an embodiment of the present invention, ions ejected from an ion source 1 travel along a straight path B, on which gate electrodes 3 are provided. When a voltage is applied from an MS mode selection controller 7 to the gate electrodes 3, the ions are introduced into a loop orbit A. Located on the loop orbit A is a second ion detector 6, which is a nondestructive type of ion detector. Detection signals of the second ion detector 6 are sent to a data processor 9, which extracts flight time spectrum data from those signals and Fourier-transforms those data to convert the time axis to a frequency axis. From the frequency spectrum thus created, the mass-to-charge ratio of each ion is calculated with high accuracy. When no voltage is applied to the gate electrodes 3, the ions ejected from the ion source 1 travel along the straight path B and arrive at a first ion detector 5. This mode of analysis requires only a short period of time and can achieve a high level of time resolution.

摘要翻译： 本发明提供了一组能够根据分析目的选择性地执行以下两种分析模式的质谱仪：第一种质谱模式，其中可以在短时间间隔内重复分析; 以及可以以高质量分辨率和高精度进行分析的第二质谱模式。 在本发明的一个实施例中，从离子源1喷出的离子沿着设置有栅电极3的直线路径B行进。 当从MS模式选择控制器7将电压施加到栅极电极3时，离子被引入环路轨道A.位于环路轨道A上的是第二离子检测器6，其是非破坏性的离子检测器。 第二离子检测器6的检测信号被发送到数据处理器9，数据处理器9从这些信号中提取飞行时间频谱数据，并对这些数据进行傅立叶变换，以将时间轴转换为频率轴。 根据这样产生的频谱，以高精度计算各离子的质荷比。 当没有电压施加到栅电极3时，从离子源1射出的离子沿着直线路径B行进并到达第一离子检测器5。 这种分析方式只需要很短的时间，就可以实现高水平的时间分辨率。