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公开(公告)号：US20190250169A1
公开(公告)日：2019-08-15
申请号：US16274058
申请日：2019-02-12
申请人： Shimadzu Corporation
发明人： Yuko FUKUYAMA , Hiroto TAMURA , Teruyo KATO
CPC分类号： G01N33/6851 , C12Q1/04 , G01N33/569 , G01N33/6848 , G16B50/00 , H01J49/00 , H01J49/0027 , H01J49/04 , H01J49/0418 , H01J49/16
摘要： In a method for analyzing a microorganism using a matrix assisted laser desorption/ionization mass spectrometer, a matrix-and-additive mixture solution prepared by mixing one or both of an alkylphosphonic acid and a surfactant with a matrix substance is used for matrix assisted laser desorption/ionization. Either an alkylphosphonic acid or a surfactant, or both of them are used as matrix additives and are mixed with the matrix substance beforehand to prepare a matrix-and-additive mixture solution. After a solution which contains a microorganism to be analyzed has been dropped onto a sample plate, the matrix-and-additive mixture solution is dropped onto that solution and dried to form a mixed crystal which contains both the constituents of the microorganism and the matrix substance. This crystal is used as a sample for MALDI-MS analysis. The sensitivity of analysis is thereby improved, without increasing the amount of time and labor required for sample preparation.
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公开(公告)号：US20190244797A1
公开(公告)日：2019-08-08
申请号：US16343192
申请日：2017-10-16
发明人： Kieran FLANAGAN
CPC分类号： H01J49/0027 , G01N27/64 , H01J49/00 , H01J49/162 , H01J49/40
摘要： A method of determining the presence of isotopes in a sample, comprising (i) providing a sample beam containing the sample; (ii) causing the sample beam to travel back and forth along a single longitudinal axis; (iii) ionising the sample beam with one or more lasers, wherein ionising the sample beam comprises operating the one or more lasers at a plurality of frequencies; (iv) determining time of flight data of a first part of the sample beam relative to a second part of the sample beam; (v) determining an ionisation time using the time of flight data; (vi) obtaining data relating to the frequency of the one or more lasers at the ionisation time; and (vii) determining the presence of isotopes in the sample using the data relating to the frequency of the one or more lasers at the ionisation time.
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公开(公告)号：US20190195855A1
公开(公告)日：2019-06-27
申请号：US16289307
申请日：2019-02-28
发明人： Changming Yang , Sum Chan
IPC分类号： G01N33/487 , H01J49/00 , G01N33/68 , G01N30/72 , G01N33/82
CPC分类号： G01N33/487 , G01N30/72 , G01N30/7233 , G01N33/6848 , G01N33/82 , G01N2030/027 , H01J49/0027 , H01J49/0031 , H01J49/0054 , Y10T436/147777
摘要： Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
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公开(公告)号：US20190164740A1
公开(公告)日：2019-05-30
申请号：US16262011
申请日：2019-01-30
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, ϕ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, ϕ, z) is the result of a perturbation W to an ideal field U(r, ϕ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ϕ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2π radians over an ion detection period Tm.
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公开(公告)号：US20190101527A1
公开(公告)日：2019-04-04
申请号：US16132076
申请日：2018-09-14
申请人： Seer, Inc.
CPC分类号： G01N33/50 , A61B5/150755 , G01N27/26 , G16B20/00 , G16B40/00 , H01J49/00 , H01J49/0027 , H01J49/165 , Y02A90/22 , Y02A90/26 , Y10T436/117497
摘要： A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.
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公开(公告)号：US20190025220A1
公开(公告)日：2019-01-24
申请号：US16021558
申请日：2018-06-28
CPC分类号： G01N21/73 , G01N1/4055 , G01N1/4077 , G01N33/22 , G01N2001/4061 , G01N2001/4088 , H01J49/0027 , H01J49/105 , H01J49/34
摘要： Systems and methods are provided for determining the organic silicon content of petroleum fractions, such as refinery fractions. This can be achieved in part based on performing solvent-enhanced selective filtration on a hydrocarbonaceous sample to substantially remove inorganic silicon from the sample while retaining at least a substantial portion of the organic silicon in the sample. After the solvent-enhanced selective filtration, the organic silicon content of the filtered sample can be determined. The ability to determine the organic silicon content of a sample can be used to identify crude fractions and/or refinery fractions that may cause contamination problems within a refinery while reducing or minimizing the occurrence of false positive tests that could result from detection of inorganic silicon.
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公开(公告)号：US20180312794A1
公开(公告)日：2018-11-01
申请号：US15966432
申请日：2018-04-30
申请人： Fluidigm Canada Inc.
发明人： Alexander V. Loboda
CPC分类号： C12M25/00 , G01N1/286 , G01N33/4833 , G01N2001/045 , G01N2001/2886 , H01J49/0027 , H01J49/04
摘要： Apparatus and methods for delivering biological samples to an ICP source of a mass cytometer are disclosed. Biological material is disposed on a plurality of discrete sites on a carrier. The plurality of discrete sites are configured to retain biological material and to release the biological material upon application of energy. The carrier is positioned in proximity to a gas conduit and upon release from the discrete sites, the biological material becomes entrained in a gas flow, which delivers discrete portions of biological material through the conduit to the ICP source for analysis by mass cytometry. The apparatus and methods can provide a continuous stream of discrete portions of biological material to a mass cytometer or mass spectrometer.
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公开(公告)号：US20180286651A1
公开(公告)日：2018-10-04
申请号：US15988698
申请日：2018-05-24
发明人： Zheng Ouyang , Robert Graham Cooks , Sandilya Venkata Garimella , Jason David Harper , Nicholas Alan Charipar
CPC分类号： H01J49/0404 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0459 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/4215
摘要： The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
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公开(公告)号：US10083825B2
公开(公告)日：2018-09-25
申请号：US15639545
申请日：2017-06-30
申请人： Micromass UK Limited
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
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公开(公告)号：US20180269051A1
公开(公告)日：2018-09-20
申请号：US15982451
申请日：2018-05-17
申请人： Micromass UK Limited
CPC分类号： H01J49/10 , G01N29/02 , G01N2291/011 , G01N2291/02818 , H01J49/0027 , H01J49/0454
摘要： An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.
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