公开(公告)号：US20240274429A1

公开(公告)日：2024-08-15

申请号：US18568417

申请日：2022-06-09

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Eric Thomas DZIEKONSKI

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/02 ,  H01J49/06

CPC classification number: H01J49/4245 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/065 ,  H01J49/4255 ,  H01J49/426

Abstract: Systems and methods described herein provide for the injection of ions into an ELIT at a variety of kinetic energies such that the ions turn around at various locations. In certain aspects, such systems and methods for operating an ELIT may reduce ion density at the turning points to reduce the impact of the space charge effect. Various aspects of the present teachings also provide for the design or optimization of the ELIT electrode spacing and/or injection potentials to reduce the impact of the space charge effect. In some related aspects, the ELIT may additionally provide time-focusing of the various ion groups at the detector as they oscillate along their respective path lengths.

公开(公告)号：US12057306B2

公开(公告)日：2024-08-06

申请号：US17312900

申请日：2019-12-09

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Eric Thomas Dziekonski

IPC: H01J49/42 ,  H01J49/06 ,  H01J49/02

CPC classification number: H01J49/4245 ,  H01J49/065 ,  H01J49/027

Abstract: An ELIT includes voltage sources (1101), switches (1102), a first set of electrode plates (1110) aligned along a central axis, and a second set of electrode plates (1120) aligned along the central axis with the first set. A first group of plates (310, 320; 810, 820) of the first set and the second set is positioned to trap ions within a first path length (340, 940). A second group of plates (410, 420) of the first set and the second set is positioned to trap ions within a shorter second path length (440, 1040). The switches select the first path length by applying voltages from the voltage sources to the first set and the second set that cause the first group of plates to trap ions within the first path length. Alternatively, the switches can select the second path length by applying voltages that cause the second group of plates to trap ions within the second path length.

公开(公告)号：US20240128070A1

公开(公告)日：2024-04-18

申请号：US18380019

申请日：2023-10-13

Applicant: Kimia Analytics Inc. ,  Quadrocore Corp.

Inventor： Sina ALAVI ,  Gholamreza JAVAHERY ,  Dmitry VALYAEV ,  Victor TITOV

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/06

CPC classification number: H01J49/0095 ,  H01J49/027 ,  H01J49/061

Abstract: The present invention is ion detection method for mass spectrometer. An electron multiplier is coupled with a conversion dynode for the detection of positive and negative ions. The aperture of the present system is ungrounded. As the ions (positive or negative) approach and go through the aperture, they induce an image current into the aperture plate which can be amplified and measured by a processing circuit. The magnitude of the image current is directly proportional to the number density, speed, charge, and polarity of ions flowing through the aperture. The measured image current is used as a means to switch between various detection modes. The measured current is calibrated and used as a reference to automatically switch between analog/counting modes, positive/negative ion detection, or various types of detectors implemented in the ion detection system.

公开(公告)号：US09997343B2

公开(公告)日：2018-06-12

申请号：US15618959

申请日：2017-06-09

Applicant: SHIMADZU CORPORATION

Inventor： Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

IPC: H01J49/40 ,  H01J49/02 ,  H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

公开(公告)号：US20170338088A1

公开(公告)日：2017-11-23

申请号：US15670502

申请日：2017-08-07

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/42 ,  H01J49/02 ,  H01J49/40

CPC classification number: H01J49/0031 ,  H01J49/027 ,  H01J49/06 ,  H01J49/406 ,  H01J49/4205 ,  H01J49/4245 ,  H01J49/4255

Abstract: A method of mass spectral analysis in an analytical electrostatic trap (14) is disclosed. The electrostatic trap (14) defines an electrostatic field volume and includes trap electrodes having static and non-ramped potentials. The method comprises injecting a continuous ion beam into the electrostatic field volume.

公开(公告)号：US09728384B2

公开(公告)日：2017-08-08

申请号：US13976218

申请日：2011-12-29

Applicant: Anatoly N. Verenchikov

Inventor： Anatoly N. Verenchikov

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/40 ,  H01J49/06 ,  H01J49/02

CPC classification number: H01J49/0031 ,  H01J49/027 ,  H01J49/06 ,  H01J49/406 ,  H01J49/4205 ,  H01J49/4245 ,  H01J49/4255

Abstract: A method of mass spectral analysis in an analytical electrostatic trap (14) is disclosed. The electrostatic trap (14) defines an electrostatic field volume and includes trap electrodes having static and non-ramped potentials. The method comprises injecting a continuous ion beam into the electrostatic field volume.

公开(公告)号：US20140339424A1

公开(公告)日：2014-11-20

申请号：US14277933

申请日：2014-05-15

Applicant: Carl Zeiss Microscopy GmbH

Inventor： Albrecht Glasmachers ,  Michel Aliman

IPC: H01J37/05 ,  H01J37/252 ,  H01J37/244

CPC classification number: H01J37/05 ,  H01J37/244 ,  H01J37/252 ,  H01J49/022 ,  H01J49/027 ,  H01J49/424 ,  H01J2237/028 ,  H01J2237/057

Abstract: A device for mass selective determination of at least one ion or of a plurality of ions is used, for example, in a measuring apparatus having an ion trap. The ion trap has a ring electrode having a first opening. A first electrode is arranged at the first opening. Furthermore, an amplifier for providing a radio-frequency storage signal for the ion trap and a first transformer are provided, said first transformer being connected to the amplifier and the first electrode in such a way that the radio-frequency storage signal is coupled into the first electrode via the first transformer.

Abstract translation: 例如，在具有离子阱的测量装置中使用用于质量选择性测定至少一种离子或多种离子的装置。 离子阱具有具有第一开口的环形电极。 第一电极布置在第一开口处。 此外，提供了一种用于提供用于离子阱的射频存储信号和第一变压器的放大器，所述第一变压器以这样的方式连接到放大器和第一电极，使得射频存储信号耦合到 第一电极经由第一变压器。

公开(公告)号：US20140061460A1

公开(公告)日：2014-03-06

申请号：US14114898

申请日：2012-05-18

Applicant: Jan-Peter Hauschild ,  Oliver Lange ,  Ulf Froehlich ,  Andreas Wieghaus ,  Alexander Kholomeev ,  Alexander Makarov

Inventor： Jan-Peter Hauschild ,  Oliver Lange ,  Ulf Froehlich ,  Andreas Wieghaus ,  Alexander Kholomeev ,  Alexander Makarov

IPC: H01J49/04

CPC classification number: H01J49/4265 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/04 ,  H01J49/38 ,  H01J49/4245 ,  H01J49/425

Abstract: A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyser; the batch of ions accumulated in the mass analyser is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyser is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyser; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyser.

Abstract translation: 提供质量分析方法和质谱仪，其中一批离子积聚在质量分析器中; 使用图像电流检测来检测在质量分析器中累积的一批离子以提供检测信号; 使用基于使用从质量分析器中累积的前一批离子的图像电流检测获得的先前检测信号的算法来控制在质量分析器中积聚的一批离子中的离子数量; 其中基于使用位于质量分析器外部的独立检测器获得的离子电流或电荷的测量来调整算法的一个或多个参数。

公开(公告)号：US07608817B2

公开(公告)日：2009-10-27

申请号：US11780667

申请日：2007-07-20

Applicant: Curt Alan Flory

Inventor： Curt Alan Flory

IPC: H01J49/26

CPC classification number: H01J49/4245 ,  H01J49/027

Abstract: A linear ion trap traps a plurality of charged particles in a charged particle trap including first and second electrode mirrors arranged along an axis at opposite ends of the particle trap, the electrode mirrors being capable, when voltage is applied thereto, of creating respective electric fields configured to reflect charged particles causing oscillation of the particles between the mirrors. The method includes: (a) introducing into the charged particle trap the plurality of charged particles, the particles having a spread in the oscillation time of the particles per oscillation; (b) applying voltage to the electrode mirrors during step (a) to induce a relatively weak self-bunching of the charged particles; and (c) after the plurality of charged particles has been introduced into the charged particle trap, waiting for a time period ΔT and then changing the voltage so as to induce a relatively stronger self-bunching among the charged particles.

Abstract translation: 线性离子阱捕集带电粒子捕集阱中的多个带电粒子，包括沿粒子捕集器相对端的轴线布置的第一和第二电极反射镜，当施加电压时，电极反射镜能够产生各自的电场 被配置为反射带电粒子，引起颗粒在反射镜之间的振荡。 该方法包括：（a）向带电粒子中引入多个带电粒子，颗粒在每个振荡的颗粒的振荡时间内具有扩散; （b）在步骤（a）期间向电极镜施加电压以引起带电粒子的相对较弱的自聚束; 并且（c）在多个带电粒子已经被引入带电粒子阱中之后，等待一段时间ΔT，然后改变电压，以引起带电粒子之间相对较强的自聚束。

公开(公告)号：US20040169137A1

公开(公告)日：2004-09-02

申请号：US10723462

申请日：2003-11-26

Inventor： Michael S. Westphall ,  Lloyd M. Smith

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/06 ,  H01J49/027

Abstract: The invention provides devices, device configurations and methods for improved sensitivity, resolution and efficiency in mass spectrometry, particularly as applied to biological molecules, including biological polymers, such as proteins and nucleic acids. More particularly, the invention provides methods and devices for analyzing and detecting electrically charged particles, especially suitable for gas phase ions generated from high molecular weight compounds. In one aspect, the invention provides devices and methods for determining the velocity, charged state or both of electrically charged particles and packets of electrically charged particles. In another aspect, the invention provides methods and devices for the time-of-flight analysis of electrically charged particles comprising spatially collimated sources. In another aspect, the invention relates to multiple detection using inductive detectors, improved methods of signal averaging and charged particle detection in coincidence.

Abstract translation: 本发明提供了用于提高质谱法的灵敏度，分辨率和效率的装置，装置配置和方法，特别是适用于包括生物聚合物如蛋白质和核酸在内的生物分子。 更具体地，本发明提供用于分析和检测带电粒子的方法和装置，特别适用于由高分子量化合物产生的气相离子。 一方面，本发明提供用于确定带电粒子和带电粒子的包的速度，带电状态或两者的装置和方法。 在另一方面，本发明提供了用于包括空间准直源的带电粒子的飞行时间分析的方法和装置。 另一方面，本发明涉及使用感应检测器的多重检测，符合信号平均和带电粒子检测的改进方法。