FUNGAL PEROXYGENASES AND METHODS OF APPLICATION
    62.
    发明申请
    FUNGAL PEROXYGENASES AND METHODS OF APPLICATION 审中-公开
    真菌过氧化物和应用方法

    公开(公告)号:US20130115662A1

    公开(公告)日:2013-05-09

    申请号:US13722019

    申请日:2012-12-20

    Applicant: Novozymes A/S

    CPC classification number: C12N9/0065

    Abstract: The invention relates to polypeptides having peroxygenase activity and compositions comprising such polypeptides, their encoding polynucleotides, expression vectors and recombinant host cells comprising such polynucleotides or vectors, methods of producing the polypeptides, as well as methods of application and uses thereof, including a process for enzymatic, regioselective oxygenation of N-heterocycles of the general formula (I) to the corresponding N-oxides of the formula (II), by converting N-heterocycles of the formula (I) with a peroxidase polypeptide in the presence of at least one oxidizing agent in a one-stage reaction process.

    Abstract translation: 本发明涉及具有过氧化酶活性的多肽和包含这些多肽的组合物,其编码多核苷酸,表达载体和包含此类多核苷酸或载体的重组宿主细胞,产生多肽的方法,以及其应用及其用途的方法,包括 通过在至少一种式(I)的存在下将式(I)的N-杂环与过氧化物酶多肽进行转化,将通式(I)的N-杂环的酶,区域选择性氧合反应至相应的式(II)的N-氧化物 氧化剂在一个阶段的反应过程中。

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