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    USING ACOUSTIC ENERGY TO COMPUTE A LUNG EDEMA FLUID STATUS INDICATION
    61.
    发明申请
    USING ACOUSTIC ENERGY TO COMPUTE A LUNG EDEMA FLUID STATUS INDICATION 有权
    使用声学能量计算肺动脉流体状态指示

    公开(公告)号：US20090036777A1

    公开(公告)日：2009-02-05

    申请号：US11833502

    申请日：2007-08-03

    申请人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

    发明人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

    IPC分类号： A61B8/00

    CPC分类号： A61B8/12 ,  A61B5/0031 ,  A61B5/08 ,  A61B5/4878 ,  A61B8/4472

    摘要： Systems and methods for monitoring lung edema fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about responsive acoustic energy echoes from a lung are described. The system comprises, among other things, an implantable device including an acoustic transducer configured to emit acoustic energy to a lung and to receive one or more responsive acoustic energy echoes from a lung. In an example, the implantable device includes a cardiac function management device having an acoustic window in a body thereof. In another example, the implantable device includes one or more subcutaneous leads. An implantable or external processor circuit is configured to receive information about the acoustic energy echoes to compute and provide a lung edema fluid status indication; such information may include an increased number or special pattern of acoustic energy echoes received or a decreased time between successively received echoes.

    摘要翻译： 描述了使用关于来自肺的响应性声能回波的信息来监测受试者肺水肿液体状态的系统和方法，例如监测受试者是否存在肺水肿。 除其他之外，该系统包括可植入装置，其包括被配置为向肺发出声能并且接收来自肺的一个或多个响应声能回波的声学换能器。 在一个示例中，可植入装置包括其身体中具有声窗口的心脏功能管理装置。 在另一示例中，可植入装置包括一个或多个皮下引线。 植入式或外部处理器电路被配置为接收关于声能回波的信息，以计算并提供肺水肿状态指示; 这样的信息可以包括接收的声能回波的增加的数量或特殊模式或连续接收的回波之间的减少的时间。

    Method and device for supporting or strengthening a portion of a lead
    62.
    发明授权
    Method and device for supporting or strengthening a portion of a lead 有权
    用于支撑或加强铅的一部分的方法和装置

    公开(公告)号：US07486994B2

    公开(公告)日：2009-02-03

    申请号：US10243625

    申请日：2002-09-13

    申请人： Paul E. Zarembo ,  Gregory R. Ley ,  Brian D. Soltis ,  Daniel L. Cox ,  Brett Cryer

    发明人： Paul E. Zarembo ,  Gregory R. Ley ,  Brian D. Soltis ,  Daniel L. Cox ,  Brett Cryer

    IPC分类号： A61N1/06

    CPC分类号： A61N1/056

    摘要： A lead assembly and method of forming a lead assembly is provided. Devices and methods of forming the lead assembly include a support coil. The support coil provides enhanced support and protection from lead damage and failure. A lead assembly and method of forming a lead assembly is also provided including at least one electrode. Electrodes may be incorporated into the support coil design. The lead assembly and method of forming a lead assembly may be incorporated with other medical devices such as an implantable defibrillator.

    摘要翻译： 提供一种引线组件和形成引线组件的方法。 形成引线组件的装置和方法包括支撑线圈。 支持线圈提供增强的支持和防止铅损坏和故障。 还提供了一种引线组件和形成引线组件的方法，其包括至少一个电极。 电极可以并入支撑线圈设计中。 引导组件和形成引线组件的方法可以与诸如可植入除颤器的其它医疗装置结合。

    Implantable lead for septal placement of pacing electrodes
    64.
    发明授权
    Implantable lead for septal placement of pacing electrodes 有权
    用于间隔放置起搏电极的可植入引线

    公开(公告)号：US07392094B2

    公开(公告)日：2008-06-24

    申请号：US10325433

    申请日：2002-12-19

    申请人： Yongxing Zhang ,  James O. Gilkerson ,  Paul E. Zarembo

    发明人： Yongxing Zhang ,  James O. Gilkerson ,  Paul E. Zarembo

    IPC分类号： A61N1/05

    CPC分类号： A61N1/057 ,  A61N1/056 ,  A61N2001/0585

    摘要： A pacing lead having a lead body configured into a pre-formed J-shape. The lead includes a pacing electrode coupled to an intermediate portion of the lead body and located distally from a bottom of the pre-formed J-shape. The lead is adapted to be placed within a heart in a J-shaped configuration with the electrode positioned proximate a ventricular septum or a right ventricular outflow tract such that at least a portion of the distal end of the lead body is located within a pulmonary artery. In one embodiment, the distal end of the lead is configured to be passively fixated within the pulmonary artery. Another aspect includes a lead body wherein a section of the intermediate portion of the lead body is less stiff than adjacent sections of the lead body. The lead includes a pacing electrode coupled to the intermediate portion of the lead body and located distally from the less stiff section. The lead is adapted to be placed within a heart in a J-shaped configuration with the less stiff section near a bottom of the J-shape such that the electrode is positioned proximate a ventricular septum or a right ventricular outflow tract and at least a portion of the distal end of the lead body is fixated within a pulmonary artery.

    摘要翻译： 具有构造成预成形的J形的引线主体的起搏引线。 引线包括连接到引线主体的中间部分并且位于远离预成形的J形的底部的起搏电极。 引线适于放置在J形构型的心脏内，其中电极位于心室隔膜或右心室流出道附近，使得引线体的远端的至少一部分位于肺动脉内 。 在一个实施例中，引线的远端构造成被动地固定在肺动脉内。 另一方面包括引线体，其中引线主体的中间部分的部分比引线本体的相邻部分刚性差。 引线包括连接到引线主体的中间部分并位于较不硬的部分的远侧的起搏电极。 引线适于放置在心脏内的J形构型中，具有靠近J形底部的较硬的部分，使得电极位于靠近心室隔膜或右心室流出道和至少一部分 引导体的远端固定在肺动脉内。

    LEAD INCLUDING A HEAT FUSED OR FORMED LEAD BODY
    65.
    发明申请
    LEAD INCLUDING A HEAT FUSED OR FORMED LEAD BODY 审中-公开
    引导包括热熔或形成的铅体

    公开(公告)号：US20080046059A1

    公开(公告)日：2008-02-21

    申请号：US11462479

    申请日：2006-08-04

    申请人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand ,  Donna Osterkamp ,  Daniel J. Cooke

    发明人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand ,  Donna Osterkamp ,  Daniel J. Cooke

    IPC分类号： A61N1/00

    CPC分类号： A61N1/056 ,  A61N1/057

    摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. In one example, the lead body may comprise a heat-formed bias portion. In another example, an outer insulator is fused to the lead body. In such an example, a lead body fusable plug may be disposed distal to at least one conductor. In another example, the lead comprises an inner boot and an outer boot fused to one another. In another example, the lead includes an atraumatic tip fused to the lead distal end portion. In another example, the lead body is reducable in size using heat shrink tubing. In yet another example, two or more lead sections may be interconnected using an outer insulator fused to the respective lead bodies. In a further example, a stiffener member is fused to the lead body adjacent a lead component.

    摘要翻译： 可植入引线包括从引线近端部分延伸到引线远端部分的引线体。 在一个示例中，引线体可以包括加热成形的偏压部分。 在另一示例中，外绝缘体熔合到引线体。 在这种示例中，引线本体可熔插塞可以设置在至少一个导体的远侧。 在另一个示例中，引线包括彼此融合的内靴和外靴。 在另一示例中，引线包括熔合到引线远端部分的无创尖端。 在另一个例子中，使用热缩管可以使引线体尺寸减小。 在又一示例中，两个或更多个引线部分可以使用融合到相应引线体的外绝缘体互连。 在另一个例子中，加强件与引线部件相邻地被引导体熔合。

    BIASING AND FIXATION FEATURES ON LEADS
    66.
    发明申请
    BIASING AND FIXATION FEATURES ON LEADS 有权
    领导的偏见和固定特征

    公开(公告)号：US20070293925A1

    公开(公告)日：2007-12-20

    申请号：US11548838

    申请日：2006-10-12

    申请人： Paul E. Zarembo ,  Brian D. Soltis

    发明人： Paul E. Zarembo ,  Brian D. Soltis

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

    摘要： A lead assembly for placement in a coronary vessel of the heart, the coronary vessel having a pericardial wall portion and a myocardial wall portion. The lead assembly comprises a lead body extending from a proximal end adapted for coupling to a pulse generator to a distal end adapted for implantation in the heart, an electrode positioned at the distal end of the lead body, and a loop biasing feature located at the distal end of the lead body. The loop biasing feature includes a resilient loop positioned to bias a portion of the electrode towards the myocardial wall portion of the coronary vessel by exerting a force against the pericardial wall portion. The loop biasing feature further includes a collar for coupling the loop biasing feature to the lead body. A method of implanting the lead assembly.

    摘要翻译： 用于放置在心脏的冠状血管中的引导组件，所述冠状血管具有心包壁部分和心肌壁部分。 引线组件包括引线本体，其从适于联接到脉冲发生器的近端延伸到适于植入心脏的远端，位于引线主体的远端的电极以及位于引线主体的环偏置特征 引线体的远端。 环偏置特征包括弹性环，其定位成通过向心包壁部分施加力而将电极的一部分朝向冠状血管的心肌壁部分偏置。 环偏置特征还包括用于将环偏置特征耦合到引线体的套环。 一种植入引线组件的方法。