公开(公告)号：US08221323B2

公开(公告)日：2012-07-17

申请号：US11833502

申请日：2007-08-03

申请人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

发明人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

IPC分类号： A61B8/00

CPC分类号： A61B8/12 ,  A61B5/0031 ,  A61B5/08 ,  A61B5/4878 ,  A61B8/4472

摘要： Systems and methods for monitoring lung edema fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about responsive acoustic energy echoes from a lung are described. The system comprises, among other things, an implantable device including an acoustic transducer configured to emit acoustic energy to a lung and to receive one or more responsive acoustic energy echoes from a lung. In an example, the implantable device includes a cardiac function management device having an acoustic window in a body thereof. In another example, the implantable device includes one or more subcutaneous leads. An implantable or external processor circuit is configured to receive information about the acoustic energy echoes to compute and provide a lung edema fluid status indication; such information may include an increased number or special pattern of acoustic energy echoes received or a decreased time between successively received echoes.

摘要翻译： 描述了使用关于来自肺的响应性声能回波的信息来监测受试者肺水肿液体状态的系统和方法，例如监测受试者是否存在肺水肿。 除其他之外，该系统包括可植入装置，其包括被配置为向肺发出声能并且接收来自肺的一个或多个响应声能回波的声学换能器。 在一个示例中，可植入装置包括其身体中具有声窗口的心脏功能管理装置。 在另一示例中，可植入装置包括一个或多个皮下引线。 植入式或外部处理器电路被配置为接收关于声能回波的信息，以计算并提供肺水肿状态指示; 这样的信息可以包括接收的声能回波的增加的数量或特殊模式或连续接收的回波之间的减少的时间。

公开(公告)号：US20090036777A1

公开(公告)日：2009-02-05

申请号：US11833502

申请日：2007-08-03

申请人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

发明人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

IPC分类号： A61B8/00

CPC分类号： A61B8/12 ,  A61B5/0031 ,  A61B5/08 ,  A61B5/4878 ,  A61B8/4472

摘要： Systems and methods for monitoring lung edema fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about responsive acoustic energy echoes from a lung are described. The system comprises, among other things, an implantable device including an acoustic transducer configured to emit acoustic energy to a lung and to receive one or more responsive acoustic energy echoes from a lung. In an example, the implantable device includes a cardiac function management device having an acoustic window in a body thereof. In another example, the implantable device includes one or more subcutaneous leads. An implantable or external processor circuit is configured to receive information about the acoustic energy echoes to compute and provide a lung edema fluid status indication; such information may include an increased number or special pattern of acoustic energy echoes received or a decreased time between successively received echoes.

摘要翻译： 描述了使用关于来自肺的响应性声能回波的信息来监测受试者肺水肿液体状态的系统和方法，例如监测受试者是否存在肺水肿。 除其他之外，该系统包括可植入装置，其包括被配置为向肺发出声能并且接收来自肺的一个或多个响应声能回波的声学换能器。 在一个示例中，可植入装置包括其身体中具有声窗口的心脏功能管理装置。 在另一示例中，可植入装置包括一个或多个皮下引线。 植入式或外部处理器电路被配置为接收关于声能回波的信息，以计算并提供肺水肿状态指示; 这样的信息可以包括接收的声能回波的增加的数量或特殊模式或连续接收的回波之间的减少的时间。

公开(公告)号：US08781604B2

公开(公告)日：2014-07-15

申请号：US12384139

申请日：2009-04-01

申请人： Yongxing Zhang ,  Yunlong Zhang

发明人： Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0568 ,  A61N1/0573

摘要： A lead includes a lead body and an electrode disposed proximate a distal end of the lead body. A retaining member is disposed proximate the distal end of the lead and adapted to retain the electrode proximate an interatrial septum when the retaining member is located on a left atrial side of the interatrial septum.

摘要翻译： 引线包括引线体和靠近引线主体的远端设置的电极。 保持构件设置在引线的远端附近，并且当保持构件位于房间隔间隔的左心房侧时适于将电极保持靠近房间隔。

公开(公告)号：US20120046565A1

公开(公告)日：2012-02-23

申请号：US13286435

申请日：2011-11-01

申请人： Yunlong Zhang ,  Julie A. Thompson ,  James O. Gilkerson ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Julie A. Thompson ,  James O. Gilkerson ,  Yongxing Zhang

IPC分类号： A61B5/0464 ,  A61B5/0468

CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61B5/7264 ,  A61N1/3956

摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.

摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。

公开(公告)号：US20080114258A1

公开(公告)日：2008-05-15

申请号：US12016843

申请日：2008-01-18

申请人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

IPC分类号： A61B5/0452

CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61B5/7264 ,  A61N1/3956

摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.

摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。

公开(公告)号：US20060116594A1

公开(公告)日：2006-06-01

申请号：US11000133

申请日：2004-11-30

申请人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61B5/7264 ,  A61N1/3956

摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.

摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。

公开(公告)号：US20060089693A1

公开(公告)日：2006-04-27

申请号：US10970569

申请日：2004-10-21

申请人： Eric Lovett ,  Bruce Tockman ,  Yongxing Zhang ,  Yunlong Zhang

发明人： Eric Lovett ,  Bruce Tockman ,  Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： A delivery system and method for delivering a right ventricular lead into a right ventricle includes a delivery device having an inflatable balloon at a distal end. The device is inserted into the venous system, the balloon is inflated and the device is floated along a blood flow path within the venous system through the heart and into the pulmonary artery. The lead is delivered into the right ventricle using the device. In one embodiment, the device is a catheter that facilitates placement of a guide wire into the right ventricle for delivery of the lead. The catheter is then removed and the lead is inserted into the right ventricle over the guide wire.

摘要翻译： 用于将右心室导线输送到右心室的输送系统和方法包括具有在远端的可充气气囊的输送装置。 将装置插入静脉系统中，气囊膨胀，并且装置沿静脉系统内的血流通道穿过心脏并进入肺动脉。 使用该装置将铅输送到右心室。 在一个实施例中，该装置是便于将导丝放置到右心室中用于输送引线的导管。 然后取出导管，引导线通过导丝插入右心室。

公开(公告)号：US20080114256A1

公开(公告)日：2008-05-15

申请号：US11559702

申请日：2006-11-14

申请人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

发明人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

IPC分类号： A61B5/021

CPC分类号： A61B5/224 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627

摘要： A method and apparatus permit sensing one or more forces exerted by one or more portions of a heart. A force transducer and displacement sensor are disclosed. A movement of one or more portions of a heart can be translated into one or more signals indicative of force. These signals can be used to provide information such as to diagnose or treat one or more conditions.

摘要翻译： 一种方法和装置允许感测由心脏的一个或多个部分施加的一个或多个力。 公开了一种力传感器和位移传感器。 心脏的一个或多个部分的运动可以被转换为指示力的一个或多个信号。 这些信号可用于提供诸如诊断或治疗一种或多种病症的信息。

公开(公告)号：US07308319B2

公开(公告)日：2007-12-11

申请号：US10970569

申请日：2004-10-21

申请人： Eric G. Lovett ,  Bruce A. Tockman ,  Yongxing Zhang ,  Yunlong Zhang

发明人： Eric G. Lovett ,  Bruce A. Tockman ,  Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： A delivery system and method for delivering a right ventricular lead into a right ventricle includes a delivery device having an inflatable balloon at a distal end. The device is inserted into the venous system, the balloon is inflated and the device is floated along a blood flow path within the venous system through the heart and into the pulmonary artery. The lead is delivered into the right ventricle using the device. In one embodiment, the device is a catheter that facilitates placement of a guide wire into the right ventricle for delivery of the lead. The catheter is then removed and the lead is inserted into the right ventricle over the guide wire.

摘要翻译： 用于将右心室导线输送到右心室的输送系统和方法包括具有在远端的可充气气囊的输送装置。 将装置插入静脉系统中，气囊膨胀，并且装置沿静脉系统内的血流通道穿过心脏并进入肺动脉。 使用该装置将铅输送到右心室。 在一个实施例中，该装置是便于将导丝放置到右心室中用于输送引线的导管。 然后取出导管，引导线通过导丝插入右心室。

公开(公告)号：US20060259084A1

公开(公告)日：2006-11-16

申请号：US11125997

申请日：2005-05-10

申请人： Yongxing Zhang ,  Yunlong Zhang

发明人： Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/36

CPC分类号： A61N1/365 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/395 ,  A61N1/3956

摘要： Various embodiments of the present subject matter relate to a lead. Various lead embodiments comprise a lead body including a first portion, a first branch and a second branch. The first portion has an end adapted to connect to an implantable medical device. The first branch and the second branch is connected to the first portion at a bifurcated region. The first branch includes a distal end adapted to be fed into a right pulmonary artery and to securely position at least one electrode within the right pulmonary artery. The second branch includes a distal end adapted to be fed into a left pulmonary artery and to securely position at least one electrode within the left pulmonary artery. Other embodiments are provided herein.

摘要翻译： 本主题的各种实施例涉及铅。 各种引线实施例包括包括第一部分，第一分支和第二分支的引线主体。 第一部分具有适于连接到可植入医疗装置的端部。 第一分支和第二分支在分叉区域连接到第一部分。 第一分支包括适于被供给到右肺动脉中的远端并且将右肺动脉内的至少一个电极牢固地定位。 第二分支包括适于供给到左肺动脉中的远端，并且将左肺动脉内的至少一个电极牢固地定位。 本文提供了其他实施例。