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    Transgenic aves producing human polyclonal antibodies
    61.
    发明申请
    Transgenic aves producing human polyclonal antibodies 审中-公开
    产生人多克隆抗体的转基因禽类

    公开(公告)号：US20050246782A1

    公开(公告)日：2005-11-03

    申请号：US10508808

    申请日：2003-03-24

    申请人： Robert Etches ,  Robert Kay ,  Philip Leighton ,  Lei Zhu

    发明人： Robert Etches ,  Robert Kay ,  Philip Leighton ,  Lei Zhu

    IPC分类号： A01K67/027 ,  C07K14/705 ,  C07K16/02 ,  C12N5/06 ,  C12N15/85

    CPC分类号： C07K16/461 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2227/30 ,  A01K2267/01 ,  C07K14/70503 ,  C07K16/02 ,  C07K2317/21 ,  C12N15/8509 ,  C12N2800/204 ,  C12N2800/30

    摘要： Human antibodies are produced in transgenic chickens having functional genetic components of the human immune system stably integrated in the genome. Techniques are described to integrate unrearranged human heavy and light chain immunoglobulin loci into the genome of the transgenic chicken. The functional description of the endogenous immunoglobulin loci yields an animal whose antibody repertoire in response to antigen is fully human. In the preferred embodiment, the human immunoglobulin locus is at least as large as the native human locus and exhibits functional class switching to yield IgG isotype antibodies. In addition to monoclonal antibodies secreted from immortalized B cell populations, polyclonal antibodies may be obtained from eggs laid by the transgenic chickens of the invention.

    摘要翻译： 在具有稳定整合在基因组中的人免疫系统的功能性遗传成分的转基因鸡中产生人抗体。 描述了将未经排列的人重链和轻链免疫球蛋白基因座整合到转基因鸡的基因组中的技术。 内源性免疫球蛋白基因座的功能描述产生一种抗体对抗原作出全部反应的动物。 在优选的实施方案中，人免疫球蛋白基因座至少与天然人基因座一样大，并显示功能类转换以产生IgG同种型抗体。 除了从永生化的B细胞群体分泌的单克隆抗体之外，多克隆抗体可以从本发明的转基因鸡放置的卵中获得。