公开(公告)号：US11897952B2

公开(公告)日：2024-02-13

申请号：US15563093

申请日：2016-03-30

申请人： City of Hope

发明人： John Williams ,  Krzysztof P. Bzymek ,  David Horne ,  Jun Xie

IPC分类号： C07K16/28 ,  C07K16/02 ,  C07K7/06 ,  C07K7/08 ,  C07K14/725 ,  A61K39/00

CPC分类号： C07K16/02 ,  C07K7/06 ,  C07K7/08 ,  C07K14/7051 ,  C07K16/2869 ,  A61K2039/505 ,  A61K2039/58 ,  A61K2039/64 ,  C07K2317/55 ,  C07K2317/60 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/01

摘要： Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments, including those where a Fab-binding molecule (Fab binding moiety) linked to a steric hindering molecule (steric hindering chemical moiety) is mechanically interlocked (e.g., through noncovalent conjugation) with the antibody or antibody fragment. Also provided are compositions that form highly stable and versatile drug delivery and diagnostic compositions.

公开(公告)号：US20180237539A1

公开(公告)日：2018-08-23

申请号：US15959797

申请日：2018-04-23

申请人： OSTRICH PHARMA KK

发明人： Yasuhiro TSUKAMOTO

IPC分类号： C07K16/40 ,  A61Q7/00 ,  A61K8/64 ,  A61K8/98 ,  A61K39/395 ,  A61Q5/02 ,  C07K16/02 ,  C07K16/26 ,  C07K16/44

CPC分类号： C07K16/40 ,  A61K8/64 ,  A61K8/98 ,  A61K39/3955 ,  A61K39/39583 ,  A61Q5/02 ,  A61Q7/00 ,  C07K16/02 ,  C07K16/26 ,  C07K16/44 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/76 ,  C12N9/001 ,  C12Y103/01022

摘要： Causes of hair loss have not been completely clarified and still remain unknown in many points. However, it appears that hair loss is partly caused by a mechanism wherein androgenic hormones in the scalp become active via the activation of DHT hormone by 5α-reductase and thus the activity of cells in hair roots is lost. In the present invention, an antibody, said antibody being obtained by inoculating a female bird with 5α-reductase or DHT as an antigen, is administered to the scalp so that the activity of DHT is suppressed and the activity of cells in hair roots is elevated. This antibody can be used in the form of a composition together with other component (s), for example, as a hair tonic together with another hair growth promoter.

公开(公告)号：US09938337B2

公开(公告)日：2018-04-10

申请号：US14493488

申请日：2014-09-23

申请人： Carviar ApS

发明人： Janus Beierholm Larsen

IPC分类号： A61K39/00 ,  C07K16/02 ,  C07K19/00 ,  C40B30/00 ,  C40B30/04 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K16/02 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/00 ,  C07K2317/23 ,  C07K2317/31 ,  C40B30/00 ,  C40B30/04 ,  G01N33/53

摘要： The present invention relates to methods for harvesting of antibodies from an antibody library. The antibodies are harvested by utilizing a certain epitope that is analogous to the epitope of the antigen used for immunization but that may differ in global physical and biochemical properties allowing the production of antibodies against antigens that normally cannot be utilized as immunizing agents. The present invention furthermore relate to fields of use for harvested antigens in industry, agriculture and healthcare.

公开(公告)号：US20170258899A1

公开(公告)日：2017-09-14

申请号：US15505379

申请日：2014-08-22

申请人： Investigacion Aplicada, S.A. DE C.V.

发明人： Eduardo Lucio Decanini

IPC分类号： A61K39/39 ,  C12N7/00 ,  A61K39/215 ,  A61K39/102 ,  A61K39/002 ,  A61K39/00 ,  A61K39/108 ,  A61K39/112 ,  A61K39/08 ,  A61K39/15 ,  C07K16/02 ,  C07K16/10 ,  C07K16/08 ,  C07K16/12 ,  C07K16/44 ,  A61K39/12

CPC分类号： A61K39/39 ,  A61K39/0002 ,  A61K39/002 ,  A61K39/0258 ,  A61K39/0275 ,  A61K39/08 ,  A61K39/102 ,  A61K39/12 ,  A61K39/15 ,  A61K39/215 ,  A61K2039/505 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55583 ,  A61K2039/575 ,  A61K2039/70 ,  C07K16/02 ,  C07K16/081 ,  C07K16/10 ,  C07K16/1242 ,  C07K16/44 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/18034 ,  C12N2720/12334 ,  C12N2770/10034 ,  C12N2770/20034

摘要： The present invention relates to a therapy for treating or preventing several diseases in animals, based on the administration of a highly concentrated avian derived immunoglobulins formulation, obtained from the egg yolk from hens previously hiper-immunized with a vaccine formulation comprising infectious agents or toxins antigens, a light mineral oil and a particulate adjuvant.

公开(公告)号：US09701737B2

公开(公告)日：2017-07-11

申请号：US10775557

申请日：2004-02-10

申请人： Peter Nash ,  Bradley M. Mitteness

发明人： Peter Nash ,  Bradley M. Mitteness

IPC分类号： A61M36/14 ,  A61K39/40 ,  A61K39/395 ,  A61K51/00 ,  C07K16/12 ,  C07K16/02 ,  C07K16/24 ,  A61K39/00

CPC分类号： C07K16/1242 ,  A61K2039/505 ,  C07K16/02 ,  C07K16/247

摘要： A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment of adherence of colony-forming immunogens in the respiratory tracts of host animals and humans. The inhibitor is made by inoculating female birds with the immunogen, harvesting the eggs which contain antibodies to the immunogen, and separating the yolk and albumin from the shells of the eggs. The yolk and albumin contents are administered to animals or human by distributing the contents directly or introducing the contents entrained in air.

公开(公告)号：US08834872B2

公开(公告)日：2014-09-16

申请号：US13927491

申请日：2013-06-26

申请人： A.C.N. 135 493 391 Pty Ltd.

发明人： Antony William Scammell

IPC分类号： A61K39/395 ,  A61K35/20 ,  C07K16/02 ,  C07K16/04 ,  G01N33/574 ,  A61K35/56 ,  C07K16/28

CPC分类号： C07K16/28 ,  A61K35/20 ,  A61K35/57 ,  C07K16/02 ,  C07K16/04 ,  C07K16/2866 ,  G01N33/57407

摘要： The present invention provides a method of preparing an antibody containing milk or egg product for use in preventing and/or treating of a non infectious medical condition. The invention also provides non-systemic modes of administering pharmaceutical compositions including the antibody containing milk or egg products, including to the GI tract.

摘要翻译： 本发明提供一种制备用于预防和/或治疗非传染性医学病症的含有乳或蛋制品的抗体的方法。 本发明还提供了包括含有抗体的乳或蛋制品（包括胃肠道）的药物组合物的非系统性模式。

公开(公告)号：US20140127220A1

公开(公告)日：2014-05-08

申请号：US14150354

申请日：2014-01-08

申请人： Wisconsin Alumni Research Foundation

发明人： Jordan Marshall Sand ,  Mark Eric Cook

IPC分类号： C07K16/24

CPC分类号： C07K16/244 ,  A23K20/147 ,  A23K50/75 ,  A61K38/00 ,  A61K38/2066 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/5428 ,  C07K16/02 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/34

摘要： The present disclosure is directed to interleukin-10 (IL-10) peptides and isolated antibodies that specifically bind to the IL-10 peptides. The IL-10 peptides and the isolated antibodies may be administered alone or as an animal feed additive to treat gastrointestinal protozoan infection in animals.

公开(公告)号：US20140017257A1

公开(公告)日：2014-01-16

申请号：US13842091

申请日：2013-03-15

申请人： Xi JIANG ,  Ying-Chun Dai

发明人： Xi JIANG ,  Ying-Chun Dai

IPC分类号： C07K16/02

CPC分类号： C07K16/02 ,  A61K2039/505 ,  C07K16/10

摘要： A method for large-scale production of anti-NoV antibodies for use as a potential treatment for NoV disease using passive immunization. NoV-specific immunoglobulins (IgY) can be produced by immunizing chickens with NoV P particles. The birds continuously produced high titers of antibodies in their eggs for at least 3 months, in which NoV-specific antibody levels reached 4.7-9.2 mg/egg yolk. The egg yolk antibodies strongly reacted with NoV P particles by both ELISA and Western blot and blocked NoV virus-like particle (VLP) and P particle binding to the histo-blood group antigen (HBGA) receptors with a BT50 of about 1:800. The chicken IgY remain stable at 70° C. for 30 min or treatment at pH 4 to 9 for 3 hr, demonstrating that chicken IgY provides large-scale production of anti-NoV antibodies for use in passive immunization against NoV infection.

摘要翻译： 用于大规模生产抗NoV抗体的方法，用作使用被动免疫的NoV疾病的潜在治疗。 通过用NoV P颗粒免疫鸡可以产生NoV特异性免疫球蛋白（IgY）。 鸟类在其卵中连续产生高滴度抗体至少3个月，其中NoV特异性抗体水平达到4.7-9.2mg /蛋黄。 蛋黄抗体通过ELISA和Western印迹与NoV病毒样颗粒（VLP）和P颗粒结合到具有约1:800的BT50的组织 - 血型抗原（HBGA）受体而与NoV P颗粒强烈反应。 鸡IgY在70℃下保持稳定30分钟或在pH 4至9下处理3小时，表明鸡IgY提供大规模生产抗NoV抗体用于针对NoV感染的被动免疫。

公开(公告)号：US08618268B2

公开(公告)日：2013-12-31

申请号：US13177114

申请日：2011-07-06

申请人： Hugh B. Fackrell ,  Linton W. Lee

发明人： Hugh B. Fackrell ,  Linton W. Lee

IPC分类号： A23J1/00

CPC分类号： C07K1/30 ,  C07K16/02

摘要： The present invention provides the method of obtaining IgA and IgM antibodies from chicken egg whites. The method involves separating chicken egg whites into two fractions which contain IgA and IgM antibodies exclusively. This separation method consists of raising the volume of the egg whites using purified water, lowering the pH of said volume, filtering the IgM fraction from said volume, precipitating the IgA fraction from the remaining volume, dialyzing the IgA fraction and drying the IgA and IgM fractions.

摘要翻译： 本发明提供从鸡蛋白获得IgA和IgM抗体的方法。 该方法包括将鸡蛋白分离成仅含有IgA和IgM抗体的两个级分。 这种分离方法包括使用纯化水提高蛋白的体积，降低所述体积的pH，从所述体积过滤IgM部分，从剩余体积中沉淀IgA部分，透析IgA部分并干燥IgA和IgM 分数。

公开(公告)号：US20130295109A1

公开(公告)日：2013-11-07

申请号：US13927491

申请日：2013-06-26

申请人： A.C.N. 135 493 391 Pty Ltd.

发明人： Antony William SCAMMELL

IPC分类号： C07K16/28

CPC分类号： C07K16/28 ,  A61K35/20 ,  A61K35/57 ,  C07K16/02 ,  C07K16/04 ,  C07K16/2866 ,  G01N33/57407

摘要： The present invention provides a method of preparing an antibody containing milk or egg product for use in preventing and/or treating of a non infectious medical condition. The invention also provides non-systemic modes of administering pharmaceutical compositions including the antibody containing milk or egg products, including to the GI tract.

摘要翻译： 本发明提供一种制备用于预防和/或治疗非传染性医学病症的含有乳或蛋制品的抗体的方法。 本发明还提供了包括含有抗体的乳或蛋制品（包括胃肠道）的药物组合物的非系统性模式。