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公开(公告)号：US5364630A
公开(公告)日：1994-11-15
申请号：US80280
申请日：1993-06-21
IPC分类号： A61K9/70 , A61K31/465 , A61F13/00
CPC分类号： A61K31/465 , A61K9/7084
摘要： Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a material with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thickness of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% of the initial equilibrated nicotine loading is in the reservoir layer.
摘要翻译： 公开了速率控制的透皮尼古丁递送系统，其利用直列粘合剂将系统保持在皮肤上。 尼古丁储存器和粘合剂中尼古丁的初始平衡浓度低于饱和度，优选在不大于0.50的热力学活性下，并且储存器包含溶解在该装置的速率控制元件基本相当于的材料中的尼古丁 不渗透 在优选的实施方案中，储存器中尼古丁的初始加载量足以防止储存器中的尼古丁的活性在给定的给药期间减少超过约75％，优选不超过约25％; 并且选择粘合剂，速率控制膜和储存层的厚度，使得初始平衡的尼古丁负载的至少50％，优选至少75％在储层中。
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62.发明授权
公开(公告)号：US5320850A
公开(公告)日：1994-06-14
申请号：US16627
申请日：1993-02-12
CPC分类号： A61K9/7084 , A61K31/57 , A61K47/14 , A61K9/0014 , Y10S514/843 , Y10S514/946 , Y10S514/947
摘要： The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) together with, optionally, a suitable permeation enhancer.
摘要翻译： 本发明提供用于经皮给药治疗有效量的合成的19-去甲孕酮（ST-1435）以及任选的合适的渗透增强剂的组合物和方法。
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公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译： 描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。 在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。 合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。 可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。 延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。
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公开(公告)号：US4940586A
公开(公告)日：1990-07-10
申请号：US257487
申请日：1988-10-13
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7069 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
摘要翻译： 描述了通过完整皮肤增强透皮递送药物的透皮通量的方法，其中药物与蔗糖单月桂酸酯或主要是蔗糖单月桂酸酯的椰子脂肪酸的蔗糖酯的混合物同时递送。 用于递送药物和蔗糖酯的治疗系统的优选实施方案使用含有高于饱和浓度的药物的基质。
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公开(公告)号：US4900555A
公开(公告)日：1990-02-13
申请号：US257481
申请日：1988-10-13
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7069 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominatly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
摘要翻译： 描述了通过完整皮肤增强透皮递送药物的经皮通量的方法，其中药物与蔗糖单月桂酸酯或主要是蔗糖单月桂酸酯的椰子脂肪酸的蔗糖酯的混合物同时递送。 用于递送药物和蔗糖酯的治疗系统的优选实施方案使用含有高于饱和浓度的药物的基质。
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公开(公告)号：US4846826A
公开(公告)日：1989-07-11
申请号：US933714
申请日：1986-11-21
申请人： Jane Shaw , Robert M. Gale
发明人： Jane Shaw , Robert M. Gale
CPC分类号： A61K9/7084 , A61K31/21
摘要： A method is disclosed for treating an ischemic condition. The method comprises coadministering topically and internally a vasodilator to a patient having the condition for treating the condition.
摘要翻译： 公开了一种治疗缺血状况的方法。 该方法包括将血管扩张剂局部和内部共同施用于具有治疗病症的病症的患者。
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公开(公告)号：US4645502A
公开(公告)日：1987-02-24
申请号：US730713
申请日：1985-05-03
申请人： Robert M. Gale , David J. Enscore
发明人： Robert M. Gale , David J. Enscore
CPC分类号： A61K9/7084
摘要： A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support member disposed between the gel and a permeable contact adhesive. A permeation enhancer reservoir delivers a permeation enhancer to the skin through the aqueous reservoir and through a permeation enhancer release rate controlling membrane which is permeable to the permeation enhancer and impermeable to the drug and water. In a preferred embodiment the permeation enhancer release rate controlling membrane forms at least a portion of said receptacle.
摘要翻译： 用于透皮递送高度电离的脂肪不溶性药物的医疗装置包括具有生理pH的水性药物储存器，所述储存器优选地是通过设置在凝胶和可渗透接触粘合剂之间的高度可渗透的支撑构件保持在不可渗透的容器中的凝胶 。 渗透增强剂储库通过水性储存器通过渗透促进剂释放速率控制膜向渗透促进剂递送渗透促进剂，所述渗透促进剂释放速率控制膜对渗透促进剂是可渗透的并且对于药物和水是不可渗透的。 在优选的实施方案中，渗透促进剂释放速率控制膜形成所述容器的至少一部分。
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公开(公告)号：US4505703A
公开(公告)日：1985-03-19
申请号：US428342
申请日：1982-09-29
申请人： Robert M. Gale , John Urquhart
发明人： Robert M. Gale , John Urquhart
CPC分类号： A61F5/441
摘要： A patient-care apparatus is disclosed for providing a biocide for controlling the presence of unwanted pathogens in a liquid. The patient-care apparatus comprises a container having means for maintaining a biocide dispensing device in a position in the container such that it dispenses an amount of biocide relative to the amount of liquid present in the container.
摘要翻译： 公开了一种用于提供用于控制液体中不需要的病原体的存在的杀生物剂的病人护理装置。 患者护理装置包括具有用于将杀生物剂分配装置保持在容器中的位置的装置的容器，使得其相对于存在于容器中的液体量分配一定量的杀生物剂。
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