摘要:
A cover for a LED sign is manufactured from a stainless steel sheet that is dimensionally larger than the array of light emitting diodes comprising the LED sign. The stainless steel sheet is laser cut and then bent to simultaneously form a plurality of apertures and a corresponding plurality of louvers each extending adjacent one of the apertures. The apertures facilitate viewing of the LED sign and the louvers shield the light emitting diodes comprising the LED sign from excessive light.
摘要:
Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: wherein R1 is Het or Ar R2 is or a pharmaceutically acceptable salt thereof.
摘要翻译:公开了式(I)的化合物,其是玻连蛋白受体拮抗剂,可用于治疗骨质疏松症:其中R 1是Het或Ar R 2或其药学上可接受的盐 其可接受的盐。
摘要:
A thrust bearing tilting pad has face with a border region including an engagement surface and defining a pocket with generally longitudinal sidebars and a bottom. The pad has leading and trailing portions, with the face extending generally longitudinally therebetween. The leading and trailing portions can be positioned upstream and downstream, respectively, relative to a direction of movement of a runner. The pad is pivotally supported by (e.g., mechanical and/or hydrostatic) pivot and can cooperate with one or more other pads and fluid within a housing to hydrodynamically and mechanically support the runner in an axial position. In another embodiment, the pad tilts free of mechanical engagement with other pads. The leading portion can define an entrance to the pocket and the sidebars can converge along the direction of motion of the runner. The pocket hydrodynamically increases pressure on the runner during rotation, and generates pressure effecting on the face counteraction force about the pivot and upstream relative to the rotation direction in order to counteract spragging force. The pocket can also have a generally tapered profile or an abrupt step.
摘要:
Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections: wherein: R1 is H, C1-6alkyl or Ar—C0-6alkyl; R2 is H, C1-6alkyl, Ar—C0-6alkyl, HO—(CH2)n— or R′OC(O)—(CH2)n—; R3 is A—C0-4alkyl, A—C2-4alkenyl, A—C2-4alkynyl, A—C3-4oxoalkenyl, A—C3-4oxoalkynyl, A—C1-4aminoalkyl, A—C3-4aminoalkenyl, A—C3-4aminoalkynyl, optionally substituted by any accessible combination of one or more of R10 or R7; R5 is H, C1-6alkyl, Ar—C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; A is H, C3-6cycloalkyl, Het or Ar; R7 is —COR8, —COCR′2R9, —C(S)R8, —S(O)kOR′, —S(O)kNR′R″, —PO(OR′), —PO(OR′)2, —B(OR′)2, —NO2, or tetrazolyl; R8 is —OR′, —NR′R″, —NR′SO2R′, —NR′OR′, or —OCR′2CO(O)R′; R9 is —OR′, —CN, —S(O)rR′, —S(O)kNR′2, —C(O)R′, C(O)NR′2, or —CO2R′; R10 is H, halo, —OR11, —CN, —NR′R11, —NO2, —CF3, CF3S(O)r—, —CO2R′, —CONR′2, A—C0-6alkyl-, A—C1-6oxoalkyl-, A—C2-6alkenyl-, A—C2-6alkynyl-, A—C0-6alkyloxy-, A—C0-6alkylamino- or A—C0-6alkyl —S(O)r—; R11 is R′, —C(O)R′, —C(O)NR′2, —C(O)OR′, —S(O)kR′, or —S(O)kNR′2; R′ is H, C1-6alkyl, Ar—C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; R″ is R′, —C(O)R′ or —C(O)OR′; R′″ is H, C1-6alkyl, Ar—C0-6alkyl, HO-(CH2)2—, R′C(O)—, (R′)2NC(O)CH2— or R′S(O)2—; X is H, C1-4alkyl, OR′, SR′, C1-4alkylsulfonyl, C1-4alkylsulfoxyl, —CN, N(R′)2, CH2N(R′)2, —NO2, —CF3, —CO2R′, —CON(R′)2, —COR′, —NR′C(O)R′, F, Cl, Br, I, or CF3S(O)r—; k is 1 or 2; m is 1, 2 or 3; n is 1 to 6; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
摘要:
Compounds of formula (I) ##STR1## wherein A.sub.1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R.sup.3 or R.sup.4 ; X.sup.1 --X.sup.2 is CHR.sup.1 --CH, CR.sup.1 .dbd.CH, NR.sup.1 --CH, S(O).sub.u --CH or O--CH; X.sup.3 is CR.sup.5 R.sup.5 ', NR.sup.5, S(O).sub.u or O; R.sup.2 is --OR', --NR'R", --NR'SO.sub.2 R'", --NR'OR', --OCR'.sub.2 C(O)OR', --OCR'.sub.2 OC(O)--R', --OCR'.sub.2 C(O)NR'.sub.2, CF.sub.3 or --COCR'.sub.2 R.sup.2 '; R.sup.3, R.sup.4 and R.sup.7 are independently H, halo, --OR.sup.12, --SR.sup.12, --CN, --NR'R.sup.12, --NO.sub.2, --CF.sub.3, CF.sub.3 S(O).sub.r --, --CO.sub.2 R', --CONR'.sub.2, R.sup.14 --C.sub.0-6 alky-, R.sup.14 --C.sub.1-6 oxoalkyl-, R.sup.14 --C.sub.2-6 alkenyl-, R.sup.14 --C.sub.2-6 alkynyl-, R.sup.14 --C.sub.0-6 alkyloxy-, R.sup.14 --C.sub.0-6 alkylamino- or R.sup.14 --C.sub.0-6 alkyl--S(O).sub.r --; R.sup.6 is W--(CR'.sub.2).sub.q --Z--(CR'R.sup.10)--U--(CR'.sub.2).sub.s --V-- or W'--(CR'.sub.2).sub.q --U--(CR'.sub.2).sub.s -- U and V are absent or CO, CR'.sub.2, C(.dbd.CR.sup.15.sub.2), S(O).sub.n, O, NR.sup.15, CR.sup.15 'OR.sup.15, CR'(OR")CR'.sub.2, CR'.sub.2 CR'(OR") C(O)CR'.sub.2, CR.sup.15.sub.2 C(O), CONR.sup.15, NR.sup.15 CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR.sup.15, NR.sup.15 C(S), SO.sub.2 NR.sup.15, NR.sup.15 SO.sub.2, N.dbd.N, NR.sup.15 NR.sup.15, NR.sup.15 CR.sup.15.sub.2, NR.sup.15 CR.sup.15.sub.2, CR.sup.15.sub.2 O, OCR.sup.15.sub.2, C$(m)ZC, CR.sup.15 .dbd.CR.sup.15, Het, or Ar, provided that U and V are not simultaneously absent, and W and W' are a nitrogen-containing substituent, and integrin receptor antagonists.
摘要:
A metering apparatus 10 for continuously supplying a specified amount of fluid material F to a desired surface. The apparatus 10 includes a reservoir 14 for maintaining a supply of fluid material, a housing 16 having a central bore 22 therethrough, a receiving opening 24 for receiving fluid material from the reservoir 14 to central bore 22, and an exit opening 26 through which fluid material exits the housing 16. A rotatable screw member 28 is provided engaged through the housing 16 within said central bore 22, and a driver 37 engaged with the screw member for rotating the screw member within the bore at between approximately 1 rpm to 2,700 rpm, and preferably approximately 1,750 rpm, in order to continuously supply fluid to the exit opening 26. At this operating level, fluid material is provided from the exit opening 26 at a flow rate of between approximately 1 to 23 grams/min, and in a thickness of approximately 0.001 to 8 mils. The reservoir 14 includes a tank 50 for the fluid material, and a motor 68 for agitating the fluid during operation of the apparatus 10. The housing 16 is secured adjacent the tank 50 to provide the fluid material from the tank to the receiving opening 24.
摘要:
An assembly and method for processing extrudate material containing curves or angles into a predetermined overall configuration, including having a die assembly for an extruder which assembly controls the cross-sectional shape or profile of the extrudate and selectively varies the path of the extrudate as it leaves the die assembly. A support member is provided which has a predetermined overall configuration and profile to receive the extrudate and maintain its configuration. A driving apparatus is also provided for continuously driving either the support member or the die assembly relative to the other while the extrudate is being received in the support member, and until the entire predetermined overall configuration has been completed. The path of the extrudate is variably directed by the die assembly as it leaves the extruder in coordination with the relative speeds involved to conform the extrudate configuration to the predetermined overall configuration of the support member.
摘要:
An improved apparatus and method for determining the existence and severity of a crack in a shaft system is provided. The apparatus includes means for mounting multiple vibration responsive output transducers around an outer circumference of the shaft system, allowing simultaneous measurements of vibrational response of the shaft system when multiple vibration responsive output transducers are mounted to the mounting means. In a first approach, the mounting means comprises a collar having two connected arcuate members, with drilled milled and tapped apertures for mounting radial input and output transducers. Torsional input and output transducers may also be mounted tangentially on the collar in drilled milled and tapped heads of bolts used to connect the two arcuate members. In a second approach, the mounting means comprises a plurality of support blocks disposed substantially symmetrically around and protruding outward from the outer collar circumference with each of the blocks orienting at least one transducer in a radial direction and at least one transducer in a tangential direction. Each block may further orient another transducer in an axial direction.
摘要:
A rotor for a dynamoelectric machine, without windings and rotatable about a central longitudinal axis, having an axially extending rotatable body and a toroidal magnet coaxially mounted on the body is constructed to provide magnetic exitation for the rotor. The rotatable body contains a first set of circumferentially spaced axially extending salient poles with circumferentially spaced recesses therebetween and a second set of similar poles at an opposite axial location. The toroidal magnet is coaxially mounted on the body between the first and second set of salient poles. A second toroidal magnet may also be mounted on the body and a magnetic spacer placed in between both toroidal magnets.