公开(公告)号：US20110144722A1

公开(公告)日：2011-06-16

申请号：US12635340

申请日：2009-12-10

申请人： Xiaoyi Min ,  Ingmar Viohl

发明人： Xiaoyi Min ,  Ingmar Viohl

IPC分类号： A61N1/05 ,  A61N1/36

CPC分类号： A61N1/0573 ,  A61N1/086

摘要： An implantable lead is provided that comprises a lead body extending along a longitudinal axis. The lead body includes a distal end and a proximal end and a lumen within the lead body. The lead also includes a header assembly provided at the distal end of the lead body. The header assembly includes a tissue engaging end. The lead also includes an electrode provided on the header assembly. The electrode is configured to deliver stimulating pulses. The lead also includes an electrode conductor provided within the lumen of the lead body and extending from the electrode to the proximal end of the lead body. An LC resonant component is provided in at least one of the lead body and the header assembly. The LC resonant component comprises a capacitor having an elongated shape that extends along the longitudinal axis of the lead body. The capacitor has a core that is located about the longitudinal axis of the lead body. The LC resonant component further comprises an inductor wire wound in multiple turns about an exterior surface of the capacitor to form an inductor.

摘要翻译： 提供了一种可植入引线，其包括沿着纵向轴线延伸的引线主体。 引线主体包括远端和近端以及引线主体内的内腔。 引线还包括设置在引线主体的远端的插头组件。 头部组件包括组织接合端。 引线还包括设置在插头组件上的电极。 电极配置为传递刺激脉冲。 引线还包括设置在引线主体的内腔内且从电极延伸到引线主体的近端的电极导体。 LC谐振元件设置在引线主体和插头组件中的至少一个中。 LC谐振元件包括具有沿引线本体的纵向轴线延伸的细长形状的电容器。 电容器具有围绕引线主体的纵向轴线定位的芯。 LC谐振分量还包括围绕电容器的外表面缠绕成多圈的电感器线，以形成电感器。

公开(公告)号：US20110125240A1

公开(公告)日：2011-05-26

申请号：US12622847

申请日：2009-11-20

申请人： Yong D. Zhao ,  Xiaoyi Min ,  Virote Indravudh ,  Ingmar Viohl ,  J. Christopher Moulder ,  Kevin L. Morgan ,  Phong D. Doan

发明人： Yong D. Zhao ,  Xiaoyi Min ,  Virote Indravudh ,  Ingmar Viohl ,  J. Christopher Moulder ,  Kevin L. Morgan ,  Phong D. Doan

IPC分类号： A61N1/05

CPC分类号： A61N1/0573 ,  A61N1/086

摘要： A biocompatible inductor for an implantable medical lead is disclosed herein. In one embodiment the biocompatible inductor may include a biocompatible bobbin and a wire wound about a barrel of the biocompatible bobbin to form a coil. The wire may include an electrically conductive core, an electrically conductive biocompatible jacket extending over the core, and a coating of high dielectric strength insulation material extending over the jacket. Additionally, the biocompatible inductor may include medical adhesive located in gaps within the coil and a polyester shrink tube covering the coil.

摘要翻译： 本文公开了用于可植入医疗引线的生物相容性电感器。 在一个实施方案中，生物相容性感应器可以包括生物相容的线轴和缠绕在生物相容线圈架的筒上的线以形成线圈。 线可以包括导电芯，在芯上延伸的导电生物相容性护套，以及在护套上延伸的高介电强度绝缘材料的涂层。 此外，生物相容性电感器可以包括位于线圈内的间隙中的医用粘合剂和覆盖线圈的聚酯收缩管。

公开(公告)号：US07949411B1

公开(公告)日：2011-05-24

申请号：US11626132

申请日：2007-01-23

申请人： Michael Yang ,  Sheldon Williams ,  Wenbo Hou ,  Kevin L. Morgan ,  Xiaoyi Min

发明人： Michael Yang ,  Sheldon Williams ,  Wenbo Hou ,  Kevin L. Morgan ,  Xiaoyi Min

IPC分类号： A61N1/05

CPC分类号： A61N1/0563 ,  A61N1/057

摘要： Embodiments include electrical leads and methods of using electrical leads that may be used for delivering both cardioversion/defibrillation signals and pacing signals and sensing to target tissue. Some of these embodiments may also be used to sense and transmit electrical signals from target tissue. Some electrical lead embodiments are configured to be delivered into a patient's intrapericardial space by non-invasive methods.

摘要翻译： 实施例包括电引线和使用电引线的方法，其可以用于将心律转复/除颤信号和起搏信号以及感测传送到目标组织。 这些实施例中的一些也可以用于感测和传输来自目标组织的电信号。 一些电引线实施例被配置为通过非侵入性方法递送到患者的心包内空间。

公开(公告)号：US07917216B1

公开(公告)日：2011-03-29

申请号：US11458649

申请日：2006-07-19

申请人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

发明人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

IPC分类号： A61N1/18

CPC分类号： A61N1/3622 ,  A61N1/0587 ,  A61N1/3686

摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.

摘要翻译： 通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。 电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。 电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。 或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

公开(公告)号：US20110034979A1

公开(公告)日：2011-02-10

申请号：US12537880

申请日：2009-08-07

申请人： Xiaoyi Min ,  Peter A. Nichols

发明人： Xiaoyi Min ,  Peter A. Nichols

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/086

摘要： To provide radio-frequency (RF) bandstop filtering within an implantable lead, such as a pacemaker lead, one or more segments of the tip and ring conductors of the lead are formed as insulated coils to function as inductive band stop filters. By forming segments of the conductors into insulated coils, a separate set of discrete or distributed inductors is not required, yet RF filtering is achieved to, e.g., reduce lead heating during magnetic resonance imaging (MRI) procedures. To enhance the degree of bandstop filtering at the RF signal frequencies of MRIs, additional capacitive elements are added. In one example, the ring electrode of the lead is configured to provide capacitive shunting to the tip conductor. In another example, a capacitive transition is provided between the outer insulated coil and proximal portions of the ring conductor. In still other examples, conducting polymers are provided to enhance capacitive shunting. The insulated coils may be spaced at ¼ wavelength locations.

摘要翻译： 为了在诸如起搏器引线的可植入引线内提供射频（RF）带阻滤波，引线的尖端和环形导体中的一个或多个段形成为用作电感带阻滤波器的绝缘线圈。 通过将导体的段形成为绝缘线圈，不需要单独的一组离散或分布式电感器，但是实现RF滤波以例如在磁共振成像（MRI）程序期间减少引线加热。 为了增强MRI的RF信号频率下的带阻滤波的程度，增加了附加的电容元件。 在一个示例中，引线的环形电极被配置为向尖端导体提供电容分流。 在另一示例中，在外绝缘线圈和环形导体的近端部分之间提供电容性跃迁。 在其它实例中，提供导电聚合物以增强电容分流。 绝缘线圈可以在1/4波长位置间隔开。

公开(公告)号：US20110022112A1

公开(公告)日：2011-01-27

申请号：US12639881

申请日：2009-12-16

申请人： Xiaoyi Min

发明人： Xiaoyi Min

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： Techniques are provided for use by implantable medical devices for controlling multi-site left ventricular (MSLV) pacing using a multi-pole left ventricular (LV) lead. In various examples, a reduced number of “V sense”, “RV pace”, and “LV pace” tests are performed to determine preferred or optimal interventricular pacing delays (VV) for use with MSLV pacing. Additionally, techniques are described for sorting the order by which LV sites are to be paced during MSLV pacing. Furthermore, techniques are described for detecting and addressing circumstances where AV/PV delays are longer than corresponding AR/PR delays during MSLV.

摘要翻译： 提供技术用于可植入医疗装置，以使用多极左心室（LV）引线来控制多部位左心室（MSLV）起搏。 在各种示例中，执行减少数量的“V感觉”，“RV步速”和“LV步调”测试以确定用于MSLV起搏的优选或最佳心室起搏延迟（VV）。 另外，描述了用于排序在MSLV起搏期间LV站点要起搏的顺序的技术。 此外，描述了用于检测和寻址在MSLV期间AV / PV延迟大于相应的AR / PR延迟的情况的技术。

公开(公告)号：US07850616B1

公开(公告)日：2010-12-14

申请号：US11154064

申请日：2005-06-15

申请人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Falkenberg Eric

发明人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Falkenberg Eric

IPC分类号： A61B5/021 ,  A61B5/0225

CPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/0464 ,  A61B5/053 ,  A61B7/00 ,  A61N1/36578

摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于 至少部分地基于时间差，决定是否存在舒张异常。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US07787951B1

公开(公告)日：2010-08-31

申请号：US11416922

申请日：2006-05-02

申请人： Xiaoyi Min

发明人： Xiaoyi Min

IPC分类号： A61N1/00

CPC分类号： A61B5/04012 ,  A61B5/0452 ,  A61N1/056 ,  A61N1/0587 ,  A61N1/08 ,  A61N1/3627 ,  A61N1/36514

摘要： An exemplary method includes providing surface ECG information acquired using a multi-lead ECG system, providing geometric information acquired using a magnetic resonance imagine system, X-ray imaging system or an ultrasound system and determining one or more stimulation sites for stimulation of the left ventricle based at least in part on the ECG information and the geometric information. Various other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性方法包括提供使用多导联ECG系统获取的表面ECG信息，提供使用磁共振想象系统，X射线成像系统或超声系统获取的几何信息，并且确定用于刺激左心室的一个或多个刺激部位 至少部分地基于ECG信息和几何信息。 还公开了各种其它示例性方法，装置，系统等。

公开(公告)号：US20100152802A1

公开(公告)日：2010-06-17

申请号：US12333176

申请日：2008-12-11

申请人： Xiaoyi Min

发明人： Xiaoyi Min

IPC分类号： A61N1/37 ,  A61N1/365

CPC分类号： A61N1/37 ,  A61B5/0452 ,  A61N1/3627 ,  A61N1/368

摘要： A system and method for using an implantable cardiac stimulation device to monitor a patient for the progress of an existing condition and/or early detection of an emerging condition based, at least in part, on measuring and evaluating the timing characteristics of the patient's atrial activity. The atrial timing characteristics are used as indicators or predictors of conditions of interest, such as heart failure (HF) and atrial fibrillation (AF). In certain implementations, the system can determine discriminating indicators of a predominant underlying cause of a condition, such as between vagal and non-vagal AF, as an indicator of a suggested therapy. The system can store data corresponding to the observed atrial timing for trending analysis as well as transmit data for offline analysis, such as via an external device.

摘要翻译： 一种系统和方法，用于至少部分地基于测量和评估患者心房活动的时间特征来使用可植入心脏刺激装置来监测患者现有病症的进展和/或新出现的病症的早期检测 。 心房时间特征被用作心脏衰竭（HF）和房颤（AF）等感兴趣条件的指标或预测指标。 在某些实施方案中，系统可以确定病症的主要潜在原因（例如迷走神经与非迷走神经AF之间）的鉴别指标，作为建议治疗的指标。 系统可以存储对应于观察到的心房定时的数据，用于趋势分析，以及用于离线分析的传输数据，例如通过外部设备。

公开(公告)号：US20100121401A1

公开(公告)日：2010-05-13

申请号：US12267390

申请日：2008-11-07

申请人： Xiaoyi Min ,  Stuart O. Schecter

发明人： Xiaoyi Min ,  Stuart O. Schecter

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684 ,  A61N1/3702

摘要： An exemplary method includes delivering stimulation energy via a right ventricular site; sensing an evoked response caused by the delivered stimulation energy at the right ventricular site; calculating a paced propagation delay for the right ventricular site (PPDRV); delivering stimulation energy via a left ventricular site; sensing an evoked response caused by the delivered stimulation energy at the left ventricular site; calculating a paced propagation delay for the left ventricular site (PPDLV); and determining an interventricular delay time (VV) for delivery of a bi-ventricular pacing therapy based in part on the paced propagation delay for the right ventricular site (PPDRV) and the paced propagation delay for the left ventricular site (PPDLV). Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性方法包括经由右心室部位递送刺激能量; 感测由右心室位置传递的刺激能量引起的诱发反应; 计算右心室位点（PPDRV）的节奏传播延迟; 通过左心室部位传递刺激能量; 感测由左心室部位传递的刺激能量引起的诱发反应; 计算左心室位点（PPDLV）的节奏传播延迟; 以及部分地基于右心室部位（PPDRV）的节奏传播延迟和左心室部位（PPDLV）的起搏传播延迟来确定用于递送双心室起搏治疗的室间延迟时间（VV）。 还公开了其它示例性方法，装置，系统等。