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    Detection of magnetic beads using a magnetoresistive device together with ferromagnetic resonance
    63.
    发明授权
    Detection of magnetic beads using a magnetoresistive device together with ferromagnetic resonance 有权
    使用磁阻器件与铁磁共振检测磁珠

    公开(公告)号：US07729093B1

    公开(公告)日：2010-06-01

    申请号：US11528878

    申请日：2006-09-28

    申请人： Yuchen Zhou

    发明人： Yuchen Zhou

    IPC分类号： G11B5/127

    CPC分类号： G01N24/10 ,  G01N24/088 ,  G01R33/5601

    摘要： A method and apparatus for detecting the presence of magnetic beads is disclosed. By providing both a static magnetic field and a magnetic field that alternates in the MHz range, or beyond, the bead can be excited into FMR (ferromagnetic resonance). The appearance of the latter is then detected by a magneto-resistive type of sensor. This approach offers several advantages over prior art methods in which the magnetic moment of the bead is detected directly.

    摘要翻译： 公开了一种用于检测磁珠存在的方法和装置。 通过提供静态磁场和在MHz范围内或以后交替的磁场，磁珠可以被激发成FMR（铁磁共振）。 然后由磁阻式传感器检测后者的外观。 这种方法提供了优于现有技术方法的几个优点，其中珠的磁矩直接被检测。

    TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION
    64.
    发明申请
    TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION 审中-公开
    温度 - 跳动动态核极化

    公开(公告)号：US20090311189A1

    公开(公告)日：2009-12-17

    申请号：US12300524

    申请日：2007-05-10

    申请人： Robert G. Griffin ,  Kan-Nian Hu ,  Chan Gyu Joo

    发明人： Robert G. Griffin ,  Kan-Nian Hu ,  Chan Gyu Joo

    IPC分类号： A61K49/06 ,  G01R33/48

    CPC分类号： G01R33/62 ,  G01N24/08 ,  G01N24/087 ,  G01N24/10 ,  G01R33/282 ,  G01R33/30 ,  G01R33/46

    摘要： In one aspect, the present invention provides a method for enhancing the sensitivity of liquid-state NMR or MRI experiments. In general, the method involves providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent with at least one unpaired electron and an analyte with at least one spin half nucleus; polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the at least one unpaired electron of the polarizing agent; melting the frozen sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the molten sample. In certain embodiments, the methods further comprise a step of freezing a sample in a magnetic field to provide the frozen sample in a magnetic field.

    摘要翻译： 一方面，本发明提供了提高液态NMR或MRI实验的灵敏度的方法。 通常，该方法包括在磁场中提供冷冻样品，其中冷冻样品包括具有至少一个不成对电子的偏振剂和具有至少一个旋转半核的分析物; 通过用具有激发所述至少一个非配对电子中的电子自旋跃迁的频率的辐射照射所述冷冻样品来使所述分析物的至少一个旋转半核偏振; 熔化冷冻样品以产生熔融样品; 和（d）检测熔融样品中分析物的至少一个旋转半核中的核自旋跃迁。 在某些实施方案中，所述方法还包括在磁场中冷冻样品以在磁场中提供冷冻样品的步骤。

    Method for the Analysis of Liposomes
    66.
    发明申请
    Method for the Analysis of Liposomes 审中-公开
    脂质体分析方法

    公开(公告)号：US20080318325A1

    公开(公告)日：2008-12-25

    申请号：US11922366

    申请日：2006-06-28

    申请人： Gabriel Blume ,  Michael Sacher ,  Dirk Teichmueller ,  Katinka Jung

    发明人： Gabriel Blume ,  Michael Sacher ,  Dirk Teichmueller ,  Katinka Jung

    IPC分类号： G01N33/92 ,  G01N24/00

    CPC分类号： G01N24/10 ,  Y10T436/24

    摘要： A method for the determination of the morphological integrity of a membrane of lipid vesicles, such as liposomes, using electron spin resonance (ESR) spectroscopy including the steps of: a) labeling the lipid vesicles with an ESR-active probe; b) producing a sample by introducing a quantity of the labeled lipid vesicles into a test medium; c) producing a positive control by introducing a quantity of the labeled lipid vesicles into a control medium and optionally a negative control by introducing a quantity of the ESR-active probe into the test medium; d) obtaining ESR spectra of the controls and the sample; and e) comparing ESR spectra of the sample and controls to determine relative morphological integrity. Morphological integrity of lipid vesicles may be quantitatively determined in the test medium by obtaining difference spectra produced using the spectra of the sample and of the positive and/or negative control.

    摘要翻译： 一种使用电子自旋共振（ESR）光谱法测定脂质囊泡膜脂质囊膜形态完整性的方法，包括以下步骤：a）用ESR活性探针标记脂质囊泡; b）通过将一定量的标记的脂质囊泡引入到测试介质中来生产样品; c）通过将一定量的ESR活性探针引入测试培养基中，将一定数量的标记的脂质囊泡引入对照培养基和任选的阴性对照中来产生阳性对照; d）获得对照和样品的ESR光谱; 和e）比较样品和对照的ESR光谱以确定相对形态学完整性。 脂质囊泡的形态完整性可以通过获得使用样品和阳性和/或阴性对照的光谱产生的差异光谱在测试培养基中定量测定。

    DETECTION WITH EVANESCENT WAVE PROBE
    67.
    发明申请
    DETECTION WITH EVANESCENT WAVE PROBE 失效
    用异常波探测器进行检测

    公开(公告)号：US20070247147A1

    公开(公告)日：2007-10-25

    申请号：US11542891

    申请日：2006-10-03

    申请人： Xiao-Dong Xiang ,  Haitao Yang ,  Gang Wang

    发明人： Xiao-Dong Xiang ,  Haitao Yang ,  Gang Wang

    IPC分类号： G01V3/00

    CPC分类号： G01R33/60 ,  G01N24/00 ,  G01N24/006 ,  G01N24/08 ,  G01N24/10 ,  G01R33/345

    摘要： Methods and systems for spatially resolved spin resonance detection in a sample of material are disclosed. Also disclosed are methods and systems for spatially resolved impedance measurements in a sample of material. The disclosed methods and samples can be used in screening of plurality of biological, chemical and material samples.

    摘要翻译： 公开了用于材料样品中空间分辨的自旋共振检测的方法和系统。 还公开了用于材料样品中的空间分辨阻抗测量的方法和系统。 所公开的方法和样品可用于筛选多个生物，化学和物质样品。

    Detection with evanescent wave probe
    70.
    发明申请
    Detection with evanescent wave probe 失效
    用ev逝波探测器进行检测

    公开(公告)号：US20070090836A1

    公开(公告)日：2007-04-26

    申请号：US11542775

    申请日：2006-10-03

    申请人： Xiao-Dong Xiang ,  Haitao Yang ,  Gang Wang

    发明人： Xiao-Dong Xiang ,  Haitao Yang ,  Gang Wang

    IPC分类号： G01V3/00

    CPC分类号： G01R33/60 ,  G01N24/00 ,  G01N24/006 ,  G01N24/08 ,  G01N24/10 ,  G01R33/345

    摘要： Methods and systems for spatially resolved spin resonance detection in a sample of material are disclosed. Also disclosed are methods and systems for spatially resolved impedance measurements in a sample of material. The disclosed methods and samples can be used in screening of plurality of biological, chemical and material samples.

    摘要翻译： 公开了用于材料样品中空间分辨的自旋共振检测的方法和系统。 还公开了用于材料样品中的空间分辨阻抗测量的方法和系统。 所公开的方法和样品可用于筛选多个生物，化学和物质样品。