公开(公告)号：US20030120318A1

公开(公告)日：2003-06-26

申请号：US10295358

申请日：2002-11-15

发明人： John A. Hauck

IPC分类号： A61N001/365

CPC分类号： A61B5/0422 ,  A61B5/1076 ,  A61B2562/0209 ,  A61B2562/046 ,  A61N1/3625 ,  A61N1/3702

摘要： Conduction volumitry is used to determine the hemo-dynamic performance of the heart under various pacing protocols to optimize cardiac output as a function of the pacing protocol.

摘要翻译： 传导体积用于确定心脏在各种起搏方案下的血液动力学性能，以优化作为起搏方案的函数的心输出量。

公开(公告)号：US20030120315A1

公开(公告)日：2003-06-26

申请号：US10027794

申请日：2001-12-20

发明人： Julio C. Spinelli ,  Qingsheng Zhu ,  Andrew P. Kramer ,  Jeffrey E. Stahmann

IPC分类号： A61N001/365

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： An apparatus and method for treating ventricular tachycardia in which paces are delivered to the ventricles at multiple pacing sites in accordance with an anti-tachycardia pacing protocol. Paces are delivered at a selected offset interval in a manner that both resynchronizes ventricular contractions and increases the probability of terminating the tachycardia.

摘要翻译： 一种用于治疗室性心动过速的装置和方法，其中根据抗心动过速起搏方案，将步道在多个起搏部位输送到心室。 以选择的偏移间隔以两者重新同步心室收缩并增加终止心动过速的可能性的方式递送步态。

公开(公告)号：US20030105492A1

公开(公告)日：2003-06-05

申请号：US10004695

申请日：2001-12-05

申请人： Cardiac Pacemakers, Inc.

发明人： Jiang Ding ,  Andrew P. Kramer ,  Julio C. Spinelli

IPC分类号： A61N001/365

CPC分类号： A61N1/365

摘要： A pacing apparatus and method for providing optimum timing for ventricular pacing without referencing atrial activities. The pacing apparatus includes a processor, at least one sensor and a pulse generator. The pacing method includes the sensing of ventricular depolarization and the identification of an early electrical event, such as a depolarization of the HIS bundle or an onset of a ventricular depolarization (Q*). The system derives the proper timing using this early electrical event which provides a predictable relationship with an optimal ventricular pacing signal.

摘要翻译： 一种用于在不参考心房活动的情况下为心室起搏提供最佳时机的起搏装置和方法。 起搏装置包括处理器，至少一个传感器和脉冲发生器。 起搏方法包括感测心室去极化和识别早期电气事件，例如HIS束的去极化或心室去极化（Q *）的发作。 该系统使用这种早期电气事件导出适当的时间，其提供与最佳心室起搏信号的可预测关系。

公开(公告)号：US20030100926A1

公开(公告)日：2003-05-29

申请号：US09987776

申请日：2001-11-16

发明人： Peter Van Dam

IPC分类号： A61N001/365

CPC分类号： A61N1/365

摘要： There is provided a system and method of rate responsive pacing, having an intrinsic QT rate sensor. The system has the capability of sensing the QT interval of intrinsic cardiac signals and constructing from such intrinsic QT data a QT reference curve. The QT reference curve is used for comparison with beat-to-beat QT interval data, in order to provide sensor information for controlling pacing rate. The system of this invention preferably utilizes DSP circuitry for determining the occurrence of a Twave event and the timing of the Twave, from which the QT interval is calculated. The system also provides for compensation of any QT interval which is calculated following ventricular pacing, so that the QT sensor is operative at all times and throughout the entire rate range experienced by the patient. The system thereby provides an enhanced QT rate responsive pacing arrangement, and avoids the need of overdrive pacing in order to obtain QT reference data.

摘要翻译： 提供了一种具有内在QT速率传感器的速率响应起搏系统和方法。 该系统具有检测内在心脏信号的QT间期的能力，并从这种内在QT数据构建QT参考曲线。 QT参考曲线用于与拍频QT间隔数据进行比较，以提供用于控制起搏速率的传感器信息。 本发明的系统优选地利用DSP电路来确定Twave事件的发生以及计算QT间隔的Twave的定时。 该系统还提供了在心室起搏之后计算的任何QT间期的补偿，使得QT传感器在患者经历的所有时间和整个速率范围内都可操作。 因此，该系统提供增强的QT速率响应起搏装置，并且避免需要过速起搏以获得QT参考数据。

公开(公告)号：US20030100925A1

公开(公告)日：2003-05-29

申请号：US09996138

申请日：2001-11-28

申请人： Medtronic, Inc.

发明人： Forrest C.M. Pape ,  Paul J. Huelskamp

IPC分类号： A61N001/365

CPC分类号： A61N1/36514 ,  A61N1/3627

摘要： An implantable device for measuring mechanical heart function of selected heart chambers using a heart contraction detection system that includes a magnetic field sensor. The system may be used for monitoring signs of acute or chronic cardiac heart failure, to enable diagnosis of the condition of the heart, to prescribe appropriate therapies, and to assess delivered pacing therapies. Distance measurements within the heart are made using the magnetic field sensor which is implanted at a sensor site in or on one of the right or left ventricle. A magnet implanted at a site relative to the other of the left or right heart ventricle is sufficiently spaced at a distance that fluctuates with expansion and contraction of the ventricles. The magnetic field sensor provides a sensor output signal having a signal magnitude proportional to the magnetic field strength of the magnet, and which is indicative of changing cardiac dimensions.

摘要翻译： 一种用于使用包括磁场传感器的心脏收缩检测系统来测量所选择的心室的机械心脏功能的可植入装置。 该系统可以用于监测急性或慢性心脏衰竭的迹象，以便能够诊断心脏的状况，开出适当的治疗方法，以及评估发放的起搏疗法。 心脏内的距离测量使用植入在右心室或左心室中的一个传感器位置的磁场传感器来进行。 植入在相对于左心室或右心室另一个的位置处的磁体在与心室的扩张和收缩波动的距离处充分间隔开。 磁场传感器提供具有与磁体的磁场强度成比例的信号幅度的传感器输出信号，并且其指示改变心脏尺寸。

公开(公告)号：US20030045908A1

公开(公告)日：2003-03-06

申请号：US09945195

申请日：2001-08-31

发明人： Catherine R. Condie ,  Robert W. Stadler ,  Lee Stylos

IPC分类号： A61N001/365

CPC分类号： A61B5/4884 ,  A61B5/0472 ,  A61N1/362

摘要： Various implantable medical devices (IMDs) are disclosed for implantation in a patient. The IMD includes pacing circuitry configured to selectively produce pacing pulses at a programmable pacing rate. In one embodiment, the IMD is configurable to subject a patient to a stress test. The IMD may be configurable to subject the patient to the stress test at the time specified by stored timing information, or in response to a signal (e.g., from a patient activator). Another embodiment of the implantable medical device (IMD) includes sensor circuitry, a memory for storing data, and a control unit. The sensor circuitry produces sensor data relating to cardiac condition. The control unit is configurable to store the sensor data in the memory until a trigger signal is received. Methods are described for performing a stress test in a patient with an IMD, and for subsequently reproducing cardiac operational states.

摘要翻译： 公开了用于植入患者体内的各种植入式医疗装置（IMD）。 IMD包括起搏电路，其配置成以可编程起搏速率选择性地产生起搏脉冲。 在一个实施例中，IMD可配置为使患者进行压力测试。 IMD可以被配置为使患者在由存储的定时信息指定的时间或者响应于信号（例如来自患者激活器）的时间对患者进行压力测试。 可植入医疗装置（IMD）的另一实施例包括传感器电路，用于存储数据的存储器和控制单元。 传感器电路产生有关心脏状况的传感器数据。 控制单元可配置为将传感器数据存储在存储器中，直到接收到触发信号。 描述了用于在具有IMD的患者中进行压力测试并且随后再现心脏操作状态的方法。

公开(公告)号：US20030004551A1

公开(公告)日：2003-01-02

申请号：US10211414

申请日：2002-08-02

申请人： Cardiac Pacemakers, Inc.

发明人： Victor T. Chen ,  Jay A. Warren ,  Gary T. Seim ,  David B. Krig ,  Jesse W. Hartley ,  Jeffrey E. Stahmann

IPC分类号： A61N001/365

CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/395 ,  A61N1/3987

摘要： A cardiac rhythm management system includes atrial shock timing optimization. Because an atrial tachyarrhythmia, such as atrial fibrillation typically causes significant variability in the ventricular heart rate, resulting in potentially proarrhythmic conditions. The system avoids delivering atrial cardioversion/defibrillation therapy during potentially proarrhythmic conditions because doing so could result in dangerous ventricular arrhythmias. Using Ventricular Rate Regularization (nullVRRnull) techniques, the system actively stabilizes the ventricular heart rate to obtain less potentially proarrhythmic conditions for delivering the atrial tachyarrhythmia therapy. The intrinsic ventricular heart rate is stabilized at a variable VRR-indicated rate, computed using an infinite impulse response (IIR) filter, and based on the underlying intrinsic ventricular heart rate. The system withholds delivery of atrial cardioversion/defibrillation therapy until the intervals between ventricular beats (nullV-V intervalsnull) meet certain criteria that decrease the chance that the atrial cardioversion/defibrillation therapy will induce a ventricular arrhythmia.

公开(公告)号：US20020177879A1

公开(公告)日：2002-11-28

申请号：US09862181

申请日：2001-05-23

发明人： Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC分类号： A61N001/365

CPC分类号： A61N1/3684 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368

摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

摘要翻译： 心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及 在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。 随后的收缩诱导刺激疗法从所选择的电极递送。

公开(公告)号：US20020161412A1

公开(公告)日：2002-10-31

申请号：US09843303

申请日：2001-04-25

申请人： Cardiac Pacemakers, Inc.

发明人： Weimin Sun ,  Bruce KenKnight ,  Jeffrey A. Hall

IPC分类号： A61N001/365

CPC分类号： A61N1/36542 ,  A61N1/3627

摘要： A method of presenting information for evaluating the condition of chronically impaired cardiac patients based on long-term assessment of activity trends, using a memoried implanted cardiac rhythm management device having a plurality of programmable parameters and one or more sensors for sensing one or more parameters related to an activity level of the patient. The method includes acquiring sensor signal data indicative of the activity level of the patient, accumulating sensor signal data in memory and using the accumulated sensor signal data to determine the activity level of the patient during a predetermined period of time, recording the activity level during a plurality of sequential time periods, adding contemporary annotation information to the activity data and producing a data record of the activity level with the annotation information during sequential time periods sufficient to indicate trends in a patient's activity level.

摘要翻译： 一种用于基于对活动趋势的长期评估来评估长期受损心脏病患者的状况的信息的方法，使用具有多个可编程参数的记忆植入心律管理装置和用于感测一个或多个参数相关的一个或多个传感器 达到患者的活动水平。 所述方法包括获取表示患者的活动水平的传感器信号数据，在存储器中累积传感器信号数据，并使用累积的传感器信号数据来确定患者在预定时间段内的活动水平，记录在 多个连续时间段，将当前注释信息添加到活动数据，并在足以指示患者活动水平的趋势的连续时间段期间用注释信息产生活动水平的数据记录。

公开(公告)号：US20020120305A1

公开(公告)日：2002-08-29

申请号：US09551310

申请日：2000-04-18

发明人： Weimin Sun ,  Veerichetty Kadhiresan ,  Bruce H. KenKnight ,  Richard S. Sanders

IPC分类号： A61N001/365

CPC分类号： A61N1/36542

摘要： A method for assessing cardiac function suitable for incorporation into an implantable cardiac rhythm management device. By measuring daily exertion levels in accordance with the invention, an assessment of cardiac function can be made that has been found to correlate well with conventional clinical classifications. The invention also provides for assessing cardiac function in conjunction with different pacing schemes designed to treat heart failure and using the assessment to select the best such scheme for the patient.

摘要翻译： 一种用于评估心脏功能的方法，其适于并入植入式心律管理装置。 通过测量根据本发明的每日运动水平，可以进行已经发现与常规临床分类良好相关的心脏功能的评估。 本发明还提供了结合用于治疗心力衰竭的不同起搏方案和使用该评估为患者选择最佳的方案来评估心脏功能。