公开(公告)号：US20040174521A1

公开(公告)日：2004-09-09

申请号：US10753155

申请日：2004-01-06

Inventor： Vladimir P. Drachev ,  Vladimir M. Shalaev ,  Andrey K. Sarychev

IPC: G01J003/44

CPC classification number: G01N21/658 ,  G01N2021/656 ,  G01Q60/22

Abstract: A Raman imaging and sensing apparatus is described. The apparatus employs a nanoantenna structure which includes a metal tip spaced from a metal surface or particle. A light beam impinges upon the nanoantenna and causes plasmon resonance. The plasmon resonance excites a sample resulting in dramatically enhanced Raman scattering of the sample. The Raman scatter is collected by a spectrophotometer which provides an output signal indicative of the composition of the sample.

Abstract translation: 描述了拉曼成像和感测装置。 该装置采用纳米天线结构，其包括与金属表面或颗粒间隔开的金属尖端。 光束撞击纳米天线并引起等离子体共振。 等离子体共振激发样品，导致样品的拉曼散射显着增加。 通过分光光度计收集拉曼散射，其提供指示样品组成的输出信号。

公开(公告)号：US20040174520A1

公开(公告)日：2004-09-09

申请号：US10484796

申请日：2004-01-23

Inventor： W Ranjith Premasiri ,  Richard H Clarke ,  M Edward Womble

IPC: G01J003/44

CPC classification number: G01N21/658 ,  C07D471/04

Abstract: The invention is directed to a method of making and using a porous solid matrix for trapping metal nanoparticles for use in detection, identification and quantification of trace levels of water contaminants using surface enhanced Raman scattering (SERS). The metal nanoparticles are polydispersed in the porous solid matrix, sufficiently separated to prevent conduction, in creating a broad area of excited electrons in response to applied radiation. In one aspect, the metal nanoparticles may be derived from gold, silver or platinum. In another aspect, the porous solid matrix is a sol-gel embedded with a polydispersion of metal for use in SERS detection. This metal nanoparticle substrate can be used on-site, is highly sensitive and easy to use for an immediate and accurate result.

Abstract translation: 本发明涉及一种制造和使用多孔固体基质捕获金属纳米粒子的方法，用于使用表面增强拉曼散射（SERS）检测，鉴定和定量痕量水分污染物。 金属纳米粒子多分散在多孔固体基质中，充分分离以防止传导，以响应于所施加的辐射产生大面积的激发电子。 在一个方面，金属纳米颗粒可以衍生自金，银或铂。 在另一方面，多孔固体基质是嵌入金属多分散体的溶胶 - 凝胶，用于SERS检测。 该金属纳米粒子基材可以现场使用，高灵敏度，易于使用，可立即得到准确的结果。

公开(公告)号：US20040165183A1

公开(公告)日：2004-08-26

申请号：US10786275

申请日：2004-02-24

Inventor： Brian J. Marquardt ,  Lloyd W. Burgess

IPC: G01J003/44

CPC classification number: G01N21/8507

Abstract: This invention provides a spherical lens optical immersion probe for use in analysis of solids, liquids, gases, powders, suspensions, slurries, particles and other homogeneous or heterogeneous samples. The use of a spherical lens in an optical immersion probe confers many advantages over traditional immersion probes including ease of use and accuracy of focus. The probe of this invention has applications to many types of optical spectroscopy methods including ultraviolet/visible (UV-Vis), near-infrared (NIR), mid-infrared (FTIR), fluorescence, and Raman spectroscopy. The spherical lens used in this invention is both the optical and sample interface in the analytical system, and may be used to both focus the excitation source and to collecting signal. Importantly, this invention has broad applications to any optical analytical technology that necessitates an optical immersion probe.

Abstract translation: 本发明提供一种用于分析固体，液体，气体，粉末，悬浮液，浆液，颗粒和其它均相或异质样品的球面透镜光学浸没探针。 在光学浸没式探针中使用球面透镜具有许多优于传统浸入式探针的优点，包括使用方便和聚焦精度。 本发明的探针可应用于许多类型的光谱学方法，包括紫外/可见光（UV-Vis），近红外（NIR），中红外（FTIR），荧光和拉曼光谱。 本发明中使用的球面透镜既是分析系统中的光学和样品界面，也可以用于聚焦激发源和收集信号。 重要的是，本发明对于需要光学浸没探针的任何光学分析技术都有广泛的应用。

公开(公告)号：US20040150817A1

公开(公告)日：2004-08-05

申请号：US10474182

申请日：2003-10-06

Inventor： Brian John Edward Smith ,  Woolfrey Andrew Mark

IPC: G01J003/44

CPC classification number: G01J3/04

Abstract: An optical slit comprises two blades 40,42 which define a slit between them, each blade being independently movable. This enables both the slit position and the slit width to be adjusted. The slit may be aligned with the centre of a light beam by aiming the light beam at a detector, traversing at least one edge of the slit across the beam path, measuring the intensity of transmitted light at the detector for each position of the slit, and feeding back a signal which adjusts the slit position for maximum light throughput. The width on the optical slit may be selected by placing the slit in the path of the light beam and measuring the light transmitted at the detector, calculating the percentage of light transmitted for that slit width and feeding back a signal which adjusts slit width to obtain the desired amount of light throughput.

Abstract translation: 光学狭缝包括两个在它们之间限定狭缝的叶片40,42，每个叶片可独立地移动。 这样可以调节狭缝位置和狭缝宽度。 狭缝可以通过将光束瞄准检测器而与光束的中心对准，穿过横穿光束路径的狭缝的至少一个边缘，测量在狭缝的每个位置的检测器处的​​透射光的强度， 并反馈调整狭缝位置的信号以获得最大的光通过量。 可以通过将狭缝放置在光束的路径中并测量在检测器处透射的光来计算光缝隙的宽度，并计算针对该狭缝宽度传输的光的百分比并反馈调节狭缝宽度的信号，从而获得 所需量的光通量。

公开(公告)号：US20040145735A1

公开(公告)日：2004-07-29

申请号：US10353063

申请日：2003-01-29

Applicant: Yeda Research and Development Company Ltd.

Inventor： Yaron Silberberg ,  Nirit Dudovich ,  Dan Oron

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01N21/65 ,  G01N2021/653 ,  G01N2021/656

Abstract: A method and system are presented for producing an output coherent anti-stokes Raman scattering (CARS) signal of a medium. The method comprises generation of a unitary optical excitation pulse that carries a pump photon, a Stokes photon and a probe photon; and inducing a CARS process in the medium by exciting the medium by the at least one such unitary optical excitation pulse.

Abstract translation: 提出了一种用于产生介质的输出相干反斯托克斯拉曼散射（CARS）信号的方法和系统。 该方法包括产生携带泵浦光子，斯托克斯光子和探针光子的单一光学激发脉冲; 以及通过所述至少一个这样的整体光激励脉冲激发介质，在所述介质中引发CARS过程。

公开(公告)号：US20040022165A1

公开(公告)日：2004-02-05

申请号：US10240420

申请日：2003-06-12

Inventor： Ortal Alpert

IPC: G11B007/00 ,  G11B003/70 ,  G11B005/84 ,  G11B007/26 ,  G02B013/14 ,  H04J014/02 ,  G02F001/35 ,  G02F002/02 ,  H01S003/00 ,  G01J003/44 ,  G11B007/24

CPC classification number: G11B7/245 ,  B82Y10/00 ,  G11B7/00455 ,  G11B7/24 ,  G11B7/244 ,  Y10S430/146

Abstract: The present invention is directed to a three-dimensional memory apparatus for storing information in a volume comprising of an active medium. The active medium is capable of changing from a first to a second isomeric form as a response to radiation of a light beam having an energy substantially equal to a first threshold energy. The concentration ratio between a first and a second isomeric form in any given volume portion represents a data unit. The active medium in the memory apparatus comprises of diarylalkene derivatives, triene derivatives, polyene derivatives or a mixture thereof. The invention is further directed to means for reading the data units from the isomeric states of the active medium in different portions of said active medium where the two isomeric forms have a substantially different absorption coefficient for absorbing energy of a second threshold energy. Reading may also be carried out by measuring the scattering pattern of the two isomeric forms.

Abstract translation: 本发明涉及一种用于存储包括活动介质的卷的信息的三维存储装置。 活性介质能够作为对具有基本上等于第一阈值能量的能量的光束的辐射从第一异构体形式改变为第二异构形式。 任何给定体积部分中第一和第二异构体形式之间的浓度比表示数据单元。 存储装置中的活性介质包括二芳基烯烃衍生物，三烯衍生物，多烯衍生物或其混合物。 本发明还涉及用于从所述活性介质的不同部分中的活性介质的异构态读出数据单元的方法，其中两种异构形式具有用于吸收第二阈值能量的能量的基本上不同的吸收系数。 读数也可以通过测量两种异构体形式的散射图来进行。

公开(公告)号：US20030231305A1

公开(公告)日：2003-12-18

申请号：US10304521

申请日：2002-11-25

Inventor： Haishan Zeng

IPC: G01J003/44

CPC classification number: G01J3/1838 ,  G01J3/0221 ,  G01J3/04 ,  G01J3/44 ,  G01J2003/2866

Abstract: Systems and methods for rapid Raman spectroscopy. The speed is improved by providing light from a sample to a light-dispersive element, such as a holographic grating, in a pattern that inversely complements distortion caused by the grating. For example, if the grating imparts a curve to the spectral lines emanating from the grating, then the light is inserted into the grating in a curve in the opposite direction. Also calibration light guides able to transmit a known, or standard, light to the detection or spectroscopy system. The calibration light guide can be useful both with traditional light transmission guides and with the light transmission guides of the present invention.

Abstract translation: 快速拉曼光谱的系统和方法。 通过将样品中的光提供给诸如全息光栅的光分散元件，以与由光栅引起的失真相反的图案来提高速度。 例如，如果光栅对从光栅发出的光谱线施加曲线，则将光以相反方向的曲线插入光栅。 还有校准光导能够将已知或标准的光传输到检测或光谱系统。 校准光导可以与传统的光传输引导件和本发明的光传输引导件一起使用。

公开(公告)号：US20030133105A1

公开(公告)日：2003-07-17

申请号：US10234580

申请日：2002-08-30

Inventor： Vladimir Semenovich Gorelik ,  Clay Markus Sharts ,  Olga N. Sharts ,  Robert P. Metzger ,  Dale F. Shellhamer ,  Georg R. Wischnath

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01J3/4406 ,  G01N21/65 ,  G01N21/658

Abstract: Detecting and determination of halooorganic compounds is described, which is applicable in the pharmaceutical industry, in fluorinated drug research and manufacturing; in the medical and clinical studies of the effects of fluoroorganic compounds; in the environmental and agricultural studies and screening, in the analysis of water, soils and air contaminated with fluoroorganic compounds.

Abstract translation: 描述了适用于制药工业，氟化药物研究和制造的卤味有机化合物的检测和测定; 在氟代有机化合物的作用的医学和临床研究中; 在环境和农业研究和筛选中，分析了氟，氟化合物污染的水，土壤和空气。

公开(公告)号：US20030081206A1

公开(公告)日：2003-05-01

申请号：US10285768

申请日：2002-11-01

Inventor： Walter M. Doyle

IPC: G01J003/44

CPC classification number: G01N21/8507 ,  G01J3/44

Abstract: A multipass system for sampling by Raman spectroscopy enhances the collected signal and provides a system having improved sensitivity. The system incorporates an injection element for inserting collimated excitation radiation into an optical path, an objective lens for focusing the excitation radiation into the sample and for collecting radiation, a blocking filter that is substantially perpendicular to the optical path and that transmits Raman shifted radiation and reflects the excitation radiation, and a mirror for causing the excitation radiation to reflect excitation radiation back and forth between the mirror and the blocking filter multiple times while Raman shifted radiation is passed through the blocking filter for collection and analysis.

Abstract translation: 通过拉曼光谱采样的多通道系统增强了收集的信号，并提供了具有改进的灵敏度的系统。 该系统包括用于将准直激发辐射插入到光路中的注入元件，用于将激发辐射聚焦到样本中并用于收集辐射的物镜，基本上垂直于光路并且传递拉曼移位的辐射的阻挡滤波器， 反射激发辐射，以及用于使激发辐射多次反射和阻挡滤波器之间来回反射激发辐射的反射镜，同时拉曼移位的辐射通过阻挡滤波器用于收集和分析。

公开(公告)号：US20030030800A1

公开(公告)日：2003-02-13

申请号：US10196001

申请日：2002-07-15

Inventor： Josh H. Golden ,  Hugh E. Gotts ,  Jay Jung ,  Marc Van Den Berg

IPC: G01J003/44

CPC classification number: G01J3/28 ,  G01J3/44 ,  G01N21/65

Abstract: A Raman spectroscopy method and system for quantifying the concentration of arsenic and/or other aqueous solution constituents. A variety of spectroscopy probe configurations and a chemical auto-dosing system are provided as well as a method for deconvoluting a spectrum with overlapping peaks to identify and quantify the concentrations of individual constituents of the solution based on a single spectrum.

Abstract translation: 用于量化砷和/或其它水溶液组分浓度的拉曼光谱法和系统。 提供了各种光谱探针配置和化学自动计量系统，以及一种用重叠峰解卷积光谱的方法，以基于单个光谱识别和量化溶液的各个成分的浓度。