公开(公告)号：US20140378421A1

公开(公告)日：2014-12-25

申请号：US14357344

申请日：2012-11-09

Applicant: ALMIRALL, S.A.

Inventor： Jose Aiguade Bosch ,  Silvia Gual Roig ,  Maria Prat Quinones ,  Carlos Puig Duran

IPC: A61K31/4709 ,  A61K45/06 ,  C07D401/12 ,  C07D409/12 ,  C07D413/14 ,  A61K31/428 ,  A61K31/4178 ,  C07D263/58 ,  A61K31/423 ,  A61K31/538 ,  C07D417/14 ,  C07D413/12 ,  C07D417/12

CPC classification number: A61K31/538 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4709 ,  A61K45/06 ,  C07D263/58 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。

公开(公告)号：US20140343097A1

公开(公告)日：2014-11-20

申请号：US14225849

申请日：2014-03-26

Applicant: ALMIRALL, S.A.

Inventor： Thorsten RUF ,  Eric MASSANA MONTEJO

IPC: A61K31/4704 ,  A61K9/00

CPC classification number: A61K31/4704 ,  A61K9/0073

Abstract: A compound which is a hydroxyquinolinone derivative of formula (I), in the form of a racemate, a stereoisomer or a mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for use in, for example, normalising the lung function of a human patient.

Abstract translation: 作为式（I）的羟基喹啉酮衍生物的化合物，其为外消旋体，立体异构体或其立体异构体或其药学上可接受的盐或溶剂合物的形式，用于例如将 人类病人

公开(公告)号：US20130047986A1

公开(公告)日：2013-02-28

申请号：US13659174

申请日：2012-10-24

Applicant: ALMIRALL, S.A. ,  Pio Orviz Proxies ,  Xavier Llauradó

Inventor： Joachim Goede ,  Karl-Heinz Lange

IPC: A61M15/00

CPC classification number: A61M15/0003 ,  A61M15/0066 ,  A61M2202/064

Abstract: In order to improve the administration of powdered pharmaceuticals, the invention proposes a storage system for powdered pharmaceuticals, in particular for use or integration in a powder inhaler, for receiving a multiplicity of doses of at least one medically active substance, with at least two storage spaces (4) which are separate from each other and are each intended to hold a multiplicity of doses of a medically active substance, and the invention also proposes an inhaler for powdered pharmaceuticals, the inhaler comprising such a pharmaceutical powder cartridge system (1) as an integral part or as an exchangeable part.

Abstract translation: 为了改善粉末状药物的给药，本发明提出了一种用于粉末状药物的储存系统，特别是用于或整合在粉末吸入器中，用于接收多种剂量的至少一种医药活性物质，其中至少两个储存 空间（4）彼此分开并且各自用于容纳多种剂量的医疗活性物质，并且本发明还提出了一种用于粉末状药物的吸入器，该吸入器包括这样的药物粉末盒系统（1），如 组成部分或可交换部分。

公开(公告)号：US20230390276A1

公开(公告)日：2023-12-07

申请号：US18249224

申请日：2021-10-15

Applicant: Aslan Pharmaceuticals Pte. Ltd. ,  ALMIRALL, S.A.

Inventor： Robert MOORE ,  Isana ENDO ,  Carl FIRTH ,  Stephen DOYLE ,  Nuria GODESSART MARINA

IPC: A61K31/455 ,  A61K45/06 ,  A61P37/00 ,  A61P19/02 ,  A61P25/02

CPC classification number: A61K31/455 ,  A61K45/06 ,  A61P37/00 ,  A61P19/02 ,  A61P25/02

Abstract: A method of treating an autoimmune disease in a patient comprising administering a therapeutically effective amount of a DHODH inhibitor or a pharmaceutically acceptable salt thereof. Also provided are formulations or compositions suitable for treating autoimmune diseases.

公开(公告)号：US20230374158A1

公开(公告)日：2023-11-23

申请号：US18031271

申请日：2021-10-12

Applicant: ALMIRALL, S.A.

Inventor： Edward HSIA ,  Vicente Marco GARCÍA GONZÁLEZ

IPC: C07K16/46

CPC classification number: C07K16/468 ,  C07K2317/31 ,  C07K2317/24

Abstract: The present invention relates to bispecific antigen binding molecules targeting (i) IL-13 or IL-13R and (ii) OX40L or OX40, pharmaceutical compositions comprising the same, and methods of treatment using the same, e.g. in treating a dermatological disease or condition such as atopic dermatitis.

公开(公告)号：US10588895B2

公开(公告)日：2020-03-17

申请号：US16045333

申请日：2018-07-25

Applicant: ALMIRALL, S.A.

Inventor： Maria Dolors Fernandez Forner ,  Maria Prat Quinones ,  Maria Antonia Buil Albero

IPC: A61K31/439 ,  A61K31/4745 ,  A61K31/56 ,  A61K45/06 ,  C07D453/02 ,  A61K9/00 ,  A61K47/26

Abstract: Provided is a method for treating chronic obstructive pulmonary disease or chronic bronchitis, or inhibiting bronchospasm, which method comprises use of a powder inhaler to administer to a human patient in need of such treatment an effective amount of a powder inhalant, wherein the powder inhalant comprises 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide.

公开(公告)号：US10456390B2

公开(公告)日：2019-10-29

申请号：US14906957

申请日：2014-07-24

Applicant: ALMIRALL, S.A.

Inventor： Monica Aparici Virgili ,  Marta Calbet Murtro ,  Montserrat Miralpeix Guell ,  Amadeu Gavalda Monedero ,  Carlos Puig Duran

IPC: A61K31/4709 ,  A61K45/06 ,  A61K31/56 ,  A61K31/573 ,  A61K31/575 ,  A61K31/58

Abstract: A combination which comprises (a) corticosteroid and (b) a dual muscarinic antagonist-β2 adrenergic agonist compound, or any pharmaceutically acceptable salt or solvate thereof.

公开(公告)号：US10214509B2

公开(公告)日：2019-02-26

申请号：US15567668

申请日：2016-04-20

Applicant: ALMIRALL, S.A.

Inventor： James Duffy ,  Mark Stuart Chambers ,  Alastair Rae ,  James Osborne ,  Isabelle Anne Lemasson ,  Michael Daniel Goldsmith ,  Andrew Sharpe ,  Silvia Fonquerna Pou

IPC: C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D249/14 ,  C07D249/06 ,  C07D231/38 ,  A61K31/4439 ,  A61K31/415 ,  A61P25/02

Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.

公开(公告)号：US10173985B2

公开(公告)日：2019-01-08

申请号：US15559120

申请日：2016-03-22

Applicant: ALMIRALL, S.A.

Inventor： Laia Sole Feu ,  Silvia Fonquerna Pou

IPC: C07D231/56 ,  C07D401/04 ,  C07D405/10 ,  C07D471/04 ,  C07D487/04 ,  A61K31/416 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/4439

Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav 1.7, to compositions containing said derivatives and processes for their preparation.

公开(公告)号：US20170319557A1

公开(公告)日：2017-11-09

申请号：US15599646

申请日：2017-05-19

Applicant: ALMIRALL, S.A.

Inventor： Maria Dolors FERNANDEZ FORNER ,  Maria PRAT QUINONES ,  Maria Antonia BUIL ALBERO

IPC: A61K31/439 ,  C07D453/02 ,  A61K9/00 ,  A61K31/56 ,  A61K31/4745 ,  A61K45/06 ,  A61K47/26

CPC classification number: A61K31/439 ,  A61K9/0073 ,  A61K9/0075 ,  A61K31/4745 ,  A61K31/56 ,  A61K45/06 ,  A61K47/26 ,  C07D453/02 ,  Y10S514/826 ,  A61K2300/00

Abstract: Provided is a powder inhaler comprising a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane wherein an anion X− is associated with the positive charge of the nitrogen atom and wherein X− is a pharmaceutically acceptable anion of a mono- or polyvalent acid