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1.发明申请5-(2--1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2 (1H)-ONE AND ITS USE IN THE TREATMENT OF PULMONARY DISEASES 审中-公开5-（2--1-羟基乙基-8-羟基喹啉-2（1H） - 酮及其在治疗肺炎中的应用公开(公告)号：US20140038928A1
公开(公告)日：2014-02-06
申请号：US14048344
申请日：2013-10-08
Applicant: ALMIRALL, S.A.
Inventor： Thorsten RUF , Eric Massana Montejo
IPC: A61K31/4704 , A61M15/00 , A61K45/06
CPC classification number: A61K31/4704 , A61K45/06 , A61M15/0065 , C07D215/26
Abstract: The present invention provides a compound which is a hydroxyquinolinone derivative of formula (I), in the form of a racemate, a stereoisomer or a mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for use in a method of treating a pulmonary disease or condition associated with β2 adrenergic receptor activity in a mammal, in which the compound is administered by the inhalatory route at a metered nominal dose of less than 5 μg.
Abstract translation: 本发明提供一种化合物，其为式（I）的羟基喹啉酮衍生物，其为外消旋体，立体异构体或其立体异构体或其药学上可接受的盐或溶剂化物的混合物形式，用于治疗肺部 与哺乳动物中的β2肾上腺素能受体活性相关的疾病或病症，其中化合物以小于5杯的计量标称剂量通过吸入途径给药。
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2.发明申请5-(2-1-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE FOR THE TREATMENT OF LUNG FUNCTION 审中-公开5-（2-羟基乙基）-8-羟基喹啉-2（1H） - 酮治疗肺功能公开(公告)号：US20140343097A1
公开(公告)日：2014-11-20
申请号：US14225849
申请日：2014-03-26
Applicant: ALMIRALL, S.A.
Inventor： Thorsten RUF , Eric MASSANA MONTEJO
IPC: A61K31/4704 , A61K9/00
CPC classification number: A61K31/4704 , A61K9/0073
Abstract: A compound which is a hydroxyquinolinone derivative of formula (I), in the form of a racemate, a stereoisomer or a mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for use in, for example, normalising the lung function of a human patient.
Abstract translation: 作为式（I）的羟基喹啉酮衍生物的化合物，其为外消旋体，立体异构体或其立体异构体或其药学上可接受的盐或溶剂合物的形式，用于例如将 人类病人
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