公开(公告)号：US20150197727A1

公开(公告)日：2015-07-16

申请号：US14414377

申请日：2013-07-10

申请人： Hiroyuki Abe ,  Hiroaki Kawasaki

发明人： Hiroyuki Abe ,  Hiroaki Kawasaki

IPC分类号： C12N5/0784 ,  C12N5/0783

CPC分类号： C12N5/0646 ,  A61K2039/5158 ,  C07K16/2896 ,  C12N5/0639 ,  C12N5/0645 ,  C12N2500/90 ,  C12N2501/02 ,  C12N2501/22 ,  C12N2501/2301 ,  C12N2501/2302 ,  C12N2501/2304 ,  C12N2501/2306 ,  C12N2501/2312 ,  C12N2501/2315 ,  C12N2501/25 ,  C12N2501/26 ,  C12N2501/58 ,  C12N2501/599 ,  C12N2506/115

摘要： The present invention relates to a method by which cells usable for an immune cell therapy are separated from peripheral blood and grown. The present invention makes it possible to provide immune system cells which are large enough in number to be used in the immune cell therapy.

摘要翻译： 本发明涉及一种可用于免疫细胞治疗的细胞与外周血分离并生长的方法。 本发明使得可以提供足够数量的用于免疫细胞治疗的免疫系统细胞。

公开(公告)号：US20130313933A1

公开(公告)日：2013-11-28

申请号：US13983895

申请日：2011-12-06

申请人： Hiroaki Kawasaki ,  Yuichi Yoshikawa

发明人： Hiroaki Kawasaki ,  Yuichi Yoshikawa

IPC分类号： H02K1/27

CPC分类号： H02K1/2706 ,  H02K1/276 ,  H02K21/16

摘要： Provided are a rotor of a motor capable of attaining a high-speed rotation by appropriately dispersing a stress exerted on a flux barrier portion while reducing a leakage of magnetic flux, and a fan driving motor including the rotor. A second inner wall surface is greater than a first inner wall surface in length in a cross-section perpendicular to a rotational axis (C). A side wall surface has a flux barrier wall surface extending from each of both ends of the second inner wall surface in the cross-section perpendicular to the rotational axis (C), the flux barrier wall surface extending outward relative to the second inner wall surface in an extending direction of the second inner wall surface and more distant from an outer edge of a rotor as it goes from the second inner wall surface toward the first inner wall surface in the cross-section perpendicular to the rotational axis (C).

摘要翻译： 提供一种能够通过适当地分散施加在磁通屏障部分上的应力来实现高速旋转的电动机的转子，同时减少磁通量的泄漏，以及包括转子的风扇驱动电动机。 在垂直于旋转轴线（C）的横截面中，第二内壁表面的长度大于第一内壁表面。 侧壁表面具有从垂直于旋转轴线（C）的横截面中从第二内壁表面的两端各自延伸的通量阻挡壁表面，阻挡壁表面相对于第二内壁表面向外延伸 在第二内壁表面的延伸方向上，在与第二内壁表面垂直于旋转轴线（C）的横截面中从第二内壁表面朝向第一内壁表面更远离转子的外边缘。

公开(公告)号：US08591218B2

公开(公告)日：2013-11-26

申请号：US13452804

申请日：2012-04-20

申请人： Hiroaki Kawasaki

发明人： Hiroaki Kawasaki

IPC分类号： B29C45/74

CPC分类号： B29C45/74 ,  B29C45/53

摘要： A injection device in molding machine is capable of efficiently heating and melting a plurality of charged pellets in a short period of time, and injecting a melting resin with superior quality.The injection device has a cylinder including a pellet supply port, a plunger, a driving unit, a melting instrument with a plurality of melting holes, which are cone-shaped passages, formed in a cylinder-shaped instrument body to communicate from inflow-side large openings to outflow-side small openings, a nozzle provided on an injection side of the cylinder and a heating unit heating the melting instrument. A diameter of the tip-end of the plunger is set to be the same as a diameter of the outflow side face of the melting machine.

摘要翻译： 成型机中的注射装置能够在短时间内有效地加热和熔化多个带电粒子，并且注入具有优良品质的熔化树脂。 注射装置具有圆筒状的圆筒状的圆柱体，该圆柱体具有圆筒状的器具主体中的流通侧的圆筒状供给口，柱塞，驱动单元，具有多个熔融孔的熔化器具， 流出侧小开口的大开口，设置在气缸的注射侧的喷嘴和加热熔化仪器的加热单元。 柱塞的前端的直径被设定为与熔化机的流出侧面的直径相同。

公开(公告)号：US20130071510A1

公开(公告)日：2013-03-21

申请号：US13452804

申请日：2012-04-20

申请人： Hiroaki KAWASAKI

发明人： Hiroaki KAWASAKI

IPC分类号： B29C45/74

CPC分类号： B29C45/74 ,  B29C45/53

摘要： A injection device in molding machine is capable of efficiently heating and melting a plurality of charged pellets in a short period of time, and injecting a melting resin with superior quality.The injection device has a cylinder including a pellet supply port, a plunger, a driving unit, a melting instrument with a plurality of melting holes, which are cone-shaped passages, formed in a cylinder-shaped instrument body to communicate from inflow-side large openings to outflow-side small openings, a nozzle provided on an injection side of the cylinder and a heating unit heating the melting instrument. A diameter of the tip-end of the plunger is set to be the same as a diameter of the outflow side face of the melting machine.

摘要翻译： 成型机中的注射装置能够在短时间内有效地加热和熔化多个带电粒子，并且注入具有优良品质的熔化树脂。 注射装置具有圆筒状的圆筒状的圆柱体，该圆柱体具有圆筒状的器具主体中的流通侧的圆筒状供给口，柱塞，驱动单元，具有多个熔融孔的熔化器具， 流出侧小开口的大开口，设置在气缸的注射侧的喷嘴和加热熔化仪器的加热单元。 柱塞的前端的直径被设定为与熔化机的流出侧面的直径相同。

公开(公告)号：US20120131017A1

公开(公告)日：2012-05-24

申请号：US13282723

申请日：2011-10-27

申请人： Hayato Kato ,  Hiroaki Kawasaki ,  Yutaka Maruyama ,  Kenji Takahashi

发明人： Hayato Kato ,  Hiroaki Kawasaki ,  Yutaka Maruyama ,  Kenji Takahashi

IPC分类号： G06F17/30

CPC分类号： G06F16/58 ,  G06F16/583

摘要： A tag information management apparatus for managing tag information indicative of an attribute relating to content data, comprising: an extraction unit that extracts existing tag information assigned to the content data; a generation unit that generates new tag information associated with the existing tag information extracted by the extraction unit; and an assignment unit that assigns the new tag information generated by the generation unit to the content data.

摘要翻译： 一种用于管理指示与内容数据相关的属性的标签信息的标签信息管理装置，包括：提取单元，提取分配给所述内容数据的现有标签信息; 产生与提取单元提取的现有标签信息相关联的新标签信息的生成单元; 以及分配单元，其将由生成单元生成的新标签信息分配给内容数据。

公开(公告)号：US20120108794A1

公开(公告)日：2012-05-03

申请号：US13266773

申请日：2009-12-03

申请人： Yoshikazu Kawai ,  Hiroaki Kawasaki ,  Naomi Kawahara

发明人： Yoshikazu Kawai ,  Hiroaki Kawasaki ,  Naomi Kawahara

IPC分类号： C07K16/00 ,  C08B15/00 ,  C08B37/00

CPC分类号： C08B37/00 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3229 ,  B01J20/3244 ,  B01J20/3248

摘要： The present invention relates to a method for producing a formyl group-containing porous base matrix, comprising the steps of introducing a spacer in a formyl group-containing porous particle; and then oxidizing the spacer with periodic acid and/or a periodate, to transform the part of the spacer into a formyl group; wherein the formyl group content in the porous particle after introduction of the spacer is not more than 3 μmol per 1 mL of the porous particle. Also, the present invention relates to a method for producing an adsorbent, comprising the step of immobilizing an amino group-containing ligand on the formyl group-containing porous base matrix. According to the present invention, a formyl-group containing porous base matrix and an adsorbent produced from the porous base matrix of which adsorption amount is high and which is has high strength and of which ligand is difficult to be leaked are provided.

摘要翻译： 本发明涉及一种含有甲酰基的多孔基质基质的制造方法，包括以下步骤：在含甲酰基的多孔质粒子中引入间隔物; 然后用高碘酸和/或高碘酸盐氧化间隔物，以将部分间隔物转化成甲酰基; 其中间隔物引入后的多孔质粒中的甲酰基含量相对于1mL多孔质粒不超过3μmol。 此外，本发明涉及一种吸附剂的制造方法，其特征在于，含有含氨基的配位体固定在含甲酰基的多孔质基体上的工序。 根据本发明，提供了含有甲酰基的多孔基质基质和由吸附量高，强度高，配体难以泄漏的多孔基质基质生成的吸附剂。

公开(公告)号：US07963157B2

公开(公告)日：2011-06-21

申请号：US12466551

申请日：2009-05-15

申请人： Hiroaki Kawasaki ,  Shuichi Adachi

发明人： Hiroaki Kawasaki ,  Shuichi Adachi

IPC分类号： G01M17/02 ,  G01L7/00

CPC分类号： B60C23/061 ,  B60C23/062

摘要： An apparatus for detecting a decrease in a tire air pressure includes: a rotation velocity information detection means for periodically detecting tire rotation velocity information for the respective wheels of a vehicle; a frequency characteristic estimate means for estimating, based on this rotation velocity information, a frequency characteristic of the rotation velocity information; and a judgment means for judging, based on the estimated frequency characteristic, a decrease in the air pressure of the tire. The frequency characteristic estimate means includes, with regard to a time-series signal including the rotation velocity information, a parameter estimate means for subjecting parameters of a three-order or more linear model to a time-series estimate; an input signal estimate means for estimating, based on the estimated linear model and the rotation velocity information that is an output signal of the linear model, an input signal to the linear model; a parameter identification means for identifying, based on the estimated input signal and the rotation velocity information, parameters of a linear model caused to have a lower order of a second order; and a resonant frequency estimate means for estimating, based on the parameters identified based on the model caused to have a lower order of the second order, a resonant frequency of the tire in a torsional direction.

摘要翻译： 一种用于检测轮胎空气压力降低的装置，包括：周期性地检测车辆各车轮的轮胎转速信息的转速信息检测装置; 频率特性估计装置，用于基于该旋转速度信息估计旋转速度信息的频率特性; 以及判断装置，用于基于估计的频率特性来判断轮胎的空气压力的降低。 频率特性估计装置包括关于包括旋转速度信息的时间序列信号，用于对三阶或更多线性模型的参数进行时间序列估计的参数估计装置; 输入信号估计装置，用于基于估计的线性模型和作为线性模型的输出信号的旋转速度信息，估计到线性模型的输入信号; 参数识别装置，用于基于估计的输入信号和旋转速度信息，识别导致具有较低二阶的线性模型的参数; 以及谐振频率估计装置，用于基于基于所述模型识别的参数来估计轮胎在扭转方向上的共振频率。

公开(公告)号：US20110107828A1

公开(公告)日：2011-05-12

申请号：US12877581

申请日：2010-09-08

申请人： Hiroaki KAWASAKI

发明人： Hiroaki KAWASAKI

IPC分类号： B60C23/02

CPC分类号： B60C23/061 ,  B60C23/062

摘要： The detection appatatus includes means for detecting rotation speed information of the respective wheels of a vehicle; means for estimating, a frequency characteristic of the wheel rotation speed information; and means for determining, based on the estimated frequency characteristic, a tire having a decreased air pressure. The frequency characteristic estimate means includes, to a time-series signal including the wheel rotation speed information: means for time-series estimating a third order or more linear model parameter; means for generating pseudo input data; means for estimating, based on the estimated linear model parameter and the pseudo input data, output data to a linear model; means for identifying, based on the pseudo input data and the estimated output, a linear model parameter for which the order is reduced to a second order; and means for estimating, based on the identified parameter for which the order is reduced to the second order, a resonance frequency of a tire torsional direction. The decreased air pressure determination means is so configured as to determine a tire having a decreased air pressure based on the estimated resonance frequency of the tire torsional direction.

摘要翻译： 检测装置包括用于检测车辆的各个车轮的转速信息的装置; 用于估计车轮转速信息的频率特性的装置; 以及用于基于估计的频率特性确定具有降低的空气压力的轮胎的装置。 频率特性估计装置包括：包括车轮转速信息的时间序列信号：用于时间序列估计三阶或更多线性模型参数的装置; 用于产生伪输入数据的装置; 用于基于估计的线性模型参数和伪输入数据估计输出数据到线性模型的装置; 用于基于所述伪输入数据和所述估计的输出来识别将所述顺序减小到二阶的线性模型参数的装置; 以及用于基于所确定的所述顺序减少到所述第二次的参数来估计轮胎扭转方向的共振频率的装置。 减小的空气压力确定装置被配置为基于估计的轮胎扭转方向的共振频率来确定具有减小的空气压力的轮胎。

公开(公告)号：US20100013616A1

公开(公告)日：2010-01-21

申请号：US12496791

申请日：2009-07-02

申请人： Hajime FUJITA ,  Hiroaki KAWASAKI

发明人： Hajime FUJITA ,  Hiroaki KAWASAKI

IPC分类号： B60C23/00

CPC分类号： B60C23/061 ,  B60C23/062

摘要： The invention includes: a rotation velocity information detection means for regularly detecting tire rotation velocity information regarding the respective wheels of a vehicle; a frequency characteristic estimation means for estimating a frequency characteristic of the rotation velocity information based on the rotation velocity information obtained from the rotation velocity information detection means; and a determination means for determining a decrease in the air pressure of the tire based on the estimated frequency characteristic. The frequency characteristic estimation means is configured to extract a resonance peak of the rotation velocity information by calculating a gain corresponding to an arbitrary frequency.

摘要翻译： 本发明包括：用于定期检测关于车辆的各个车轮的轮胎转速信息的转速信息检测装置; 频率特性估计装置，用于基于从旋转速度信息检测装置获得的旋转速度信息来估计旋转速度信息的频率特性; 以及确定装置，用于基于估计的频率特性来确定轮胎的空气压力的降低。 频率特性估计装置被配置为通过计算与任意频率相对应的增益来提取旋转速度信息的共振峰值。

公开(公告)号：US20060088837A1

公开(公告)日：2006-04-27

申请号：US10512386

申请日：2003-04-25

申请人： Kazunari Taira ,  Hiroaki Kawasaki

发明人： Kazunari Taira ,  Hiroaki Kawasaki

IPC分类号： C12Q1/68 ,  A01K67/027 ,  C07H21/02 ,  A61K48/00

CPC分类号： A01K67/0275 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2217/20 ,  A01K2227/101 ,  A01K2227/103 ,  A01K2227/105 ,  A01K2227/106 ,  A01K2227/107 ,  A01K2227/108 ,  A61K31/7088 ,  A61K48/00 ,  A61K2121/00 ,  C12N15/111 ,  C12N15/85 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/3519 ,  C12N2310/53 ,  C12N2330/30 ,  C12N2830/00 ,  C12N2830/003 ,  C12N2830/85

摘要： The present inventors discovered that an RNA molecule can be efficiently transferred into cytoplasm and exert RNAi effects, by producing a stem loop RNA molecule from the DNA that encodes this RNA molecule, with the use of a tRNA promoter. Also, the RNAi effects can be exerted effectively, by introducing a cytoplasm translocation signal sequence into the DNA that encodes a stem loop RNA molecule. Moreover, the RNAi effects can be exerted effectively by transferring a transcriptional product into the cytoplasm, using a pol II-type promoter. In this case, cytotoxicity can be reduced by co-expressing a Dicer gene. Furthermore, an effective dsRNA can be constructed by treating a dsRNA or a stem loop RNA molecule with Dicer protein. Knockout cells lacking a gene of interest can be conveniently constructed, using these stem-loop RNA molecule expression systems.

摘要翻译： 本发明人通过使用tRNA启动子，通过从编码该RNA分子的DNA产生茎环RNA分子，可以有效地将RNA分子转移到细胞质中并发挥RNAi作用。 此外，通过将细胞质易位信号序列引入到编码茎环RNA分子的DNA中，可以有效地发挥RNAi作用。 此外，通过使用pol II型启动子将转录产物转移到细胞质中可以有效地发挥RNAi作用。 在这种情况下，可以通过共表达Dicer基因来减少细胞毒性。 此外，通过用Dicer蛋白处理dsRNA或茎环RNA分子可以构建有效的dsRNA。 使用这些茎环RNA分子表达系统，可以方便地构建缺乏目的基因的敲除细胞。