公开(公告)号：US10704110B2

公开(公告)日：2020-07-07

申请号：US16319167

申请日：2017-07-24

Applicant: Korea Research Institute of Chemical Technology

Inventor： Ju-Hyun Yu ,  In-Yong Eom ,  Kyung-Sik Hong

IPC: C13K1/04 ,  B01D21/26 ,  B01D25/12 ,  C12P19/02 ,  C12P19/14

Abstract: The present invention relates to a method for effectively recovering a sugar solution containing glucose and saccharogenic residues after saccharification using an acid or a saccharification enzyme of a wood-based or algae biomass, and a device for implementing the method. More specifically, the present invention relates to a method capable of recovering a sugar solution using minimal equipment and water after aggregating fine particles by adding a protein suspension to a suspension of glucose and saccharogenic residues which are produced by saccharifying cellulose by adding an acid or saccharification enzyme to the biomass, while capable of minimizing an amount of saccharide lost in the residues, and a device for implementing the method.

公开(公告)号：US20200155537A1

公开(公告)日：2020-05-21

申请号：US16603993

申请日：2018-02-28

Applicant: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Seong Eon RYU ,  Tae Hyun PARK ,  Kwang Hwan LEE ,  Ju Seop KANG ,  Shin Hee KIM ,  Kyoung Tae NAM ,  Hyeon Kyu LEE

IPC: A61K31/47 ,  A61P25/24 ,  A61P35/00

Abstract: The present invention relates to a pharmaceutical composition comprising a DUSP1 inhibitor. The pharmaceutical composition comprising the DUSP1 inhibitor according to the present invention can solve the problems of inhibitors that target the active site because it inhibits DUSP1 by an allosteric inhibitory mechanism, and is effective for preventing or treating diseases involving DUSP1 enzymes, for example, a cancer such as a liver cancer, a breast cancer and a pancreatic cancer, a hepatitis C, and a depression. In particular, the DUSP1 inhibitor according to the present invention is very effective in treating a depression because it directly acts on neuronal growth.

公开(公告)号：US10647686B2

公开(公告)日：2020-05-12

申请号：US16347480

申请日：2017-11-01

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kwangho Lee ,  Gildon Choi ,  Na Ri Lee ,  Sang Jun Park ,  Myoung Eun Jung ,  Seong Jin Kim ,  Kyung-Min Yang ,  Jihee Lee

IPC: A61K31/505 ,  C07D239/48 ,  A61K9/00 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  C07D405/12

Abstract: The present invention relates to compounds represented by Formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is chloro or methyl; R2 is hydrogen or chloro; R3 is hydrogen, fluoro, chloro, bromo, methyl, ethyl, isopropyl, pentyl, hexyl, octyl, methoxy, phenoxy, (4-nitrophenyl)sulfonyl, piperidin-4-yl, or piperazin-1-yl; R4 is hydrogen, chloro, methyl or trifluoromethyl, phenoxy, (4-nitrophenyl)sulfonyl or piperidin-4-yl; or R3 and R4, together with the carbons to which they are attached, form a fused ring selected form the group consisting of: n is 1 or 2. These compounds according to the present invention remarkably inhibits activity of DRAK that inhibits signal systems of TGF-β, which is known to suppress cancer growth, and thus the novel pyrimidine compounds can be used as a pharmaceutical composition for preventing or treating cancer and can be used as a pharmaceutical composition for preventing or treating inflammatory disease.

公开(公告)号：US20200085803A1

公开(公告)日：2020-03-19

申请号：US16470014

申请日：2017-12-15

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Sungchan CHO ,  Miri CHOI ,  Joo Youn LEE

IPC: A61K31/444 ,  A23L33/10

Abstract: The present invention relates to a pharmaceutical composition the prevention or treatment of DYRK-related diseases containing a pyridine-based compound as an active ingredient, a pyridine-based compound of the present invention which is used as an active ingredient of the pharmaceutical composition inhibits the activity of DYRK1A with very high efficacy and selectivity, thereby can be used effectively in the prevention or treatment of DYRK-related diseases, such as Down syndrome, degenerative brain diseases, cancer, and metabolic diseases.

公开(公告)号：US10593816B2

公开(公告)日：2020-03-17

申请号：US15541797

申请日：2016-01-08

Applicant: Korea Research Institute of Chemical Technology

Inventor： Sang-Il Seok ,  Jun Hong Noh ,  Jang Won Seo ,  Nam Joong Jeon ,  Young Chan Kim

IPC: H01L31/0264 ,  H01L31/0224 ,  H01L31/04 ,  H01L31/18 ,  H01L51/00 ,  H01L51/42 ,  H01L31/0256

Abstract: A method for manufacturing a device comprising an inorganic/organic hybrid perovskite compound film, according to the present invention, comprises the steps of: a) laminating a first structure and a second structure to allow the first surface layer and the second surface layer to be in contact with each other, the first structure comprising a first surface layer containing at least one of materials i) to v) below, the second structure comprising a second surface layer containing, independently from the first surface layer, at least one of materials i) to v) below; and b) applying heat and physical force to the laminate in which the first structure and the second structure are laminated: i) an inorganic/organic hybrid perovskite compound, ii) an organic halide, iii) a metal halide, iv) an inorganic/organic hybrid perovskite compound precursor, and v) a metal halide precursor.

公开(公告)号：US20200062730A1

公开(公告)日：2020-02-27

申请号：US16609805

申请日：2018-05-11

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Jong Yeon HWANG ,  Jae Du HA ,  Sung Yun CHO ,  Pil Ho KIM ,  Chang Soo YUN ,  Chi Hoon PARK ,  Chong Ock LEE ,  Sang Un CHOI ,  Joo Youn LEE ,  Sunjoo AHN

IPC: C07D401/04 ,  A61P35/00 ,  C07D401/14

Abstract: The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.

公开(公告)号：US20200058413A1

公开(公告)日：2020-02-20

申请号：US16309317

申请日：2017-12-08

Applicant: Joint Stock Company "Scientific-research institute of chemical technology" ,  JOINT STOCK COMPANY "SCIENCE AND INNOVATIONS"

Inventor： Vasiliy Vasil'evich SHILOV

IPC: G21C3/62 ,  G21C3/04

Abstract: The invention is related to nuclear technologies, in particular, to the technology of producing nuclear oxide fuel for fuel elements, this oxide fuel can be used for manufacturing palletized nuclear fuel from uranium dioxide to be consumed by NPPs. The essence of the invention: this method of producing palletized nuclear fuel from uranium dioxide involves preparation of uranium dioxide moulding powder with/without uranium oxide, at this point powdered uranium dioxide is used as a raw material for preparation of moulding powder. Powdered uranium dioxide should be in the following proportion: O/U=2.37±0.04, it is obtained using a renowned method—by air heating of powdered uranium dioxide (ceramic grade) with the following proportion O/U=2.01−2.15. The technical result of the invention is increased mechanical strength of sintered pellets and a larger grain size of sintered pellets. 3 appendices, 1 diagram, 2 figures

公开(公告)号：US10561991B2

公开(公告)日：2020-02-18

申请号：US15976437

申请日：2018-05-10

Applicant: Korea Research Institute of Chemical Technology

Inventor： Jeong Hoon Kim ,  Bong Jun Chang ,  Su Young Moon

IPC: B01D69/12 ,  B01D67/00 ,  B01D69/02 ,  B01D69/10 ,  B01D71/82 ,  B01D71/68 ,  B01D71/26 ,  B01D71/30 ,  B01D71/76

Abstract: The present invention provides a anion-exchange composite membrane comprising a copolymer containing a vinylbenzyl trialkylammonium salt repeating unit, a styrene repeating unit and a divinylbenzene derived repeating unit; an olefin additive; a plasticizer; and a polyvinyl halide polymer. The anion-exchange composite membrane comprising a copolymer containing a vinylbenzyl trialkylammonium salt repeating unit, a styrene repeating unit and a divinylbenzene derived repeating unit; an olefin additive; a plasticizer; and polyvinylidene fluoride of the present invention not only displays low electrical resistance, excellent ion exchange capability, excellent ionic conductivity, excellent mechanical properties, excellent chemical properties, and processability, but also is easy to regulate its ion exchange capacity and ionic conductivity. Also, the composite membrane of the invention is easier to produce and cheaper to manufacture than the conventional anion-exchange composite membrane.

公开(公告)号：US20200039984A1

公开(公告)日：2020-02-06

申请号：US16480908

申请日：2018-01-25

Applicant: Dong Wha Pharm. Co., Ltd. ,  Korea Research Institute of Chemical Technology

Inventor： Kwangho Lee ,  Gildon Choi ,  Imran Ali ,  Joo Yun Lee ,  Jin Soo Lee ,  Whui Jung Park ,  Yong Tae Kim ,  Seung Hwan Kim ,  Jung Hwan Kim ,  Jae-Kyung Lim

IPC: C07D487/04 ,  C07D519/00 ,  A61P35/00

Abstract: Provided are a novel [1,2,4]triazolo[4,3-a]quinoxaline derivative, a method for preparing the same, and a pharmaceutical composition for preventing or treating bromodomain extra-terminal (BET) protein-related diseases including cancer and autoimmune diseases, containing the same as an active ingredient.

公开(公告)号：US20190218368A1

公开(公告)日：2019-07-18

申请号：US16248556

申请日：2019-01-15

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Byoung Gak Kim ,  Yong Seok Kim ,  Young Jae Yoo ,  Dong Gyun Kim ,  Seong Wook Lee ,  Jun Woo Jeon ,  Bo Mi Maeng

IPC: C08K5/375 ,  C08G75/0204 ,  C07C323/41

CPC classification number: C08K5/375 ,  C07C323/41 ,  C08G75/0204

Abstract: The present invention relates to a compound having a bis phenylene group substituted with alkylamide, a composition comprising the same for the control of polyphenylene polymer flowability and a method for controlling polyphenylene polymer flowability using the same. The said compound can improve the flowability of polyphenylene polymer so that it can be used for processing polyphenylene polymer to improve the flowability, thereby providing economic benefits by diversifying PPS parts and improving workability. In addition, the said compound can control and improve the flowability by regulating the length of phenyl-conjugated alkyl, so that it can be effectively used as a flowability regulator of polyphenylene polymer particularly polyphenylene sulfide.