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    COMPOSITIONS AND METHODS FOR TREATMENT OF OCULAR DISEASES
    72.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT OF OCULAR DISEASES 有权

    公开(公告)号：US20210206834A1

    公开(公告)日：2021-07-08

    申请号：US17154864

    申请日：2021-01-21

    Applicant: MOR RESEARCH APPLICATIONS LTD.

    Inventor： Dov WEINBERGER ,  Tami LIVNAT ,  Yael NISGAV

    IPC: C07K14/745 ,  A61P27/02 ,  A61K45/06

    Abstract: Methods for treating and/or preventing choroidal neovascularization (CNV) or retinal leakage associated with CNV are disclosed, comprising the use of activated protein C (APC) and/or an APC variant. A disclosed method may be applied in the treatment or prevention of ocular diseases, disorders or conditions that are caused directly by CVN, feature development of CNV as a secondary stage or a complication thereof, and/or feature CNV as a synchronous or asynchronous sequela thereof. An exemplary disease treatable by a disclosed method is neovascular age-related macular degeneration (nAMD).

    Instrument for extracting nucleus of eye lens during cataract surgery
    75.
    发明授权
    Instrument for extracting nucleus of eye lens during cataract surgery 有权

    公开(公告)号：US10744032B2

    公开(公告)日：2020-08-18

    申请号：US15775515

    申请日：2016-11-10

    Applicant: MOR RESEARCH APPLICATIONS LTD.

    Inventor： Eliyahu Bsharim ,  Tova Lifshitz ,  Nadav Yaakov Belfair

    IPC: A61F9/007

    Abstract: An ophthalmic surgical instrument for fragmenting the lens nucleus of an eye, and method of use thereof. The instrument includes an elongated handle portion, a tubular head portion at the handle portion distal end, at least three prongs with cutting tips, and a holding ring. The prongs are selectively retractable into and deployable from the head portion. The holding ring selectively contracts and expands to adjust the deployment width of the prongs. The instrument is inserted toward the eye lens through a corneal incision, while the head portion is opened to deploy the prongs to slide over and grasp onto the lens nucleus at a posterior position thereof. The instrument is then withdrawn toward the eye lens anterior while the head portion is closed to retract the prongs, such that the prong cutting tips cut along the lens nucleus, so as to fragment the lens nucleus into multiple segments.

    METHODS OF DIAGNOSING MALIGNANT DISEASES
    77.
    发明申请
    METHODS OF DIAGNOSING MALIGNANT DISEASES 审中-公开

    公开(公告)号：US20190383815A1

    公开(公告)日：2019-12-19

    申请号：US16480342

    申请日：2018-01-25

    Applicant: MOR RESEARCH APPLICATIONS LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

    Inventor： Esther RABIZADEH ,  Izchak CHERNY ,  Aida INBAL

    IPC: G01N33/574 ,  G01N33/86

    Abstract: A method for diagnosing a malignant proliferative disease or disorder in a subject, and/or for following up, monitoring or prognosticating the therapy of a malignant proliferative disease or disorder in a subject is disclosed. The method is based on measurement of platelet-mediated fibrinogen-like protein 2 (FGL2) activity in a sample essentially comprising platelets obtained from the subject. In accordance with the disclosed method, platelet-mediated FGL2 activity level higher than control is indicative of the presence of a malignant proliferative disease or disorder in a subject.

    GRASPER WITH INCREASED GRASPING SURFACE AREA
    78.
    发明申请
    GRASPER WITH INCREASED GRASPING SURFACE AREA 审中-公开

    公开(公告)号：US20190142448A1

    公开(公告)日：2019-05-16

    申请号：US16098474

    申请日：2017-05-04

    Applicant: MOR Research Applications Ltd.

    Inventor： Igor Igov

    IPC: A61B17/29

    Abstract: The subject matter discloses a grasper, comprising a grasping element at a distal end of the grasper; wherein the grasping element is configurable to at least a narrow state having a narrow cross-section, and at least an expanded state having an expanded cross-section; wherein the grasping element configured in the narrow state is insertable through an incision or narrow orifice into a body; wherein the grasping element configured in the expanded state has an increased grasping surface; and wherein the grasping element is configurable from the narrow state to the expanded state after insertion into the body.

    Treatments for fibrotic diseases
    79.
    发明授权
    Treatments for fibrotic diseases 有权

    公开(公告)号：US10206900B2

    公开(公告)日：2019-02-19

    申请号：US15083370

    申请日：2016-03-29

    Applicant: MOR RESEARCH APPLICATIONS LTD.

    Inventor： Ayala Pollack ,  Zeev Dvashi

    IPC: A61K31/335 ,  C07K16/40

    Abstract: Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (PVR) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (TAK1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided.

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