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    MAGNETIC NANOPARTICLES USEFUL FOR MAGNETIC SENSOR DETECTION ESPECIALLY IN BIOSENSOR APPLICATIONS
    74.
    发明申请
    MAGNETIC NANOPARTICLES USEFUL FOR MAGNETIC SENSOR DETECTION ESPECIALLY IN BIOSENSOR APPLICATIONS 审中-公开
    磁传感器特别适用于生物传感器应用中的磁性纳米粒子

    公开(公告)号：US20160158155A1

    公开(公告)日：2016-06-09

    申请号：US14227277

    申请日：2014-03-27

    申请人： Makoto Murakami ,  Bing Liu

    发明人： Makoto Murakami ,  Bing Liu

    IPC分类号： A61K9/16 ,  G01N33/58 ,  A61K49/18

    CPC分类号： A61K9/1617 ,  A61K49/1839 ,  B22F1/0014 ,  B22F1/0018 ,  B22F2304/054 ,  B82Y25/00 ,  C22C2202/02 ,  G01N33/58 ,  G01N2446/80 ,  G01R33/1269 ,  G01R33/1276 ,  Y10S977/773 ,  Y10S977/932

    摘要： Disclosed is process for preparing magnetic nanoparticles (MNPs) that results in very sensitive MNPs that can be used in a variety of diagnostic and analytical methods. The MNPs exhibit superparamagnetism and find special use in giant magnetoresistance sensors (GMRS). The MNPs are created by a process that permits one to tune the size of nanoparticles to a range of from 10 to 20 nanometers with a very small particle size distribution of +/−2 nanometers or less. The MNPs can be tagged with a variety of markers and thus find use in many analytical assays, cell sorting techniques, imaging methods, drug delivery methods and cancer treatments. The inventive MNPs can be detected in magnetic file strengths of 2000 Oe or less.

    摘要翻译： 公开了制备磁性纳米颗粒（MNPs）的方法，其导致非常敏感的MNP，其可用于各种诊断和分析方法。 MNPs表现出超顺磁性，并在巨磁电阻传感​​器（GMRS）中发现特殊用途。 通过允许将纳米颗粒的尺寸调整到10至20纳米范围的方法来产生MNP，其具有+/- 2纳米或更小的非常小的粒度分布。 MNP可以用多种标记进行标记，因此可用于许多分析测定，细胞分选技术，成像方法，药物递送方法和癌症治疗。 可以在2000Oe以下的磁文件强度中检测本发明的MNP。

    Nanoparticle production in liquid with multiple-pulse ultrafast laser ablation
    75.
    发明授权
    Nanoparticle production in liquid with multiple-pulse ultrafast laser ablation 有权
    多脉冲超快激光烧蚀液中纳米粒子生产

    公开(公告)号：US08858676B2

    公开(公告)日：2014-10-14

    申请号：US12951423

    申请日：2010-11-22

    申请人： Bing Liu ,  Zhendong Hu ,  Yong Che ,  Makoto Murakami

    发明人： Bing Liu ,  Zhendong Hu ,  Yong Che ,  Makoto Murakami

    IPC分类号： B22F9/14 ,  B01J19/12 ,  B22F9/04 ,  B22F1/00

    CPC分类号： B01J19/121 ,  B22F1/0018 ,  B22F9/04 ,  B22F2999/00 ,  Y10S977/889 ,  B22F2202/11

    摘要： A method for generating nanoparticles in a liquid comprises generating groups of ultrafast laser pulses, each pulse in a group having a pulse duration of from 10 femtoseconds to 200 picoseconds, and each group containing a plurality of pulses with a pulse separation of 1 to 100 nanoseconds and directing the groups of pulses at a target material in a liquid to ablate it. The multiple pulse group ablation produces nanoparticles with a reduced average size, a narrow size distribution, and improved production efficiency compared to prior pulsed ablation systems.

    摘要翻译： 用于在液体中产生纳米颗粒的方法包括产生超快激光脉冲组，组中的每个脉冲具有10飞秒至200皮秒的脉冲持续时间，并且每组包含脉冲间隔为1至100纳秒的多个脉冲 并将脉冲组定向在液体中的目标材料以烧蚀它。 与先前的脉冲消融系统相比，多脉冲组消融产生具有降低的平均尺寸，窄尺寸分布和提高的生产效率的纳米颗粒。

    Frequency spectrum analyzing apparatus
    76.
    发明授权
    Frequency spectrum analyzing apparatus 有权
    频谱分析装置

    公开(公告)号：US08725463B2

    公开(公告)日：2014-05-13

    申请号：US13120433

    申请日：2009-09-09

    申请人： Natsuko Kitamura ,  Yoshiaki Akimoto ,  Jiro Takagi ,  Atsushi Kurauchi ,  Masayuki Yoshiiri ,  Hirotaka Komatsu ,  Kazuhiko Hirota ,  Makoto Murakami

    发明人： Natsuko Kitamura ,  Yoshiaki Akimoto ,  Jiro Takagi ,  Atsushi Kurauchi ,  Masayuki Yoshiiri ,  Hirotaka Komatsu ,  Kazuhiko Hirota ,  Makoto Murakami

    IPC分类号： G01R23/16 ,  G06F17/00 ,  G06F19/00 ,  G01L23/22 ,  G05B15/00

    CPC分类号： G01R23/16 ,  G01L23/221 ,  G01L23/225 ,  G01M15/12 ,  G05B15/00 ,  G06F17/00 ,  G06F19/00

    摘要： A frequency spectrum analyzing apparatus for performing a frequency spectrum analysis with respect to a detected value of an operating parameter of an internal combustion engine in synchronism with rotation of the engine, is provided. The operating parameter is sampled at predetermined time intervals, and a sampled value is converted to a digital value. Intensities of first and second elements are calculated with respect to a predetermined number of the sampled values. The first elements and second elements respectively correspond to a plurality of frequency components contained in the detected value, and a phase of the second element differs from a phase of the first element by 90 degrees. Frequency component intensities corresponding to the plurality of frequency components are calculated in synchronism with rotation of the engine, using the first element intensities and the second element intensities. The frequency component intensities are calculated by replacing a part of an integrated value of the first element intensities, and a part of an integrated value of the second element intensities respectively with corresponding preceding calculated values, when an rotational speed of the engine is higher than or equal to a set threshold value.

    摘要翻译： 提供了一种频谱分析装置，用于与发动机的旋转同步地执行关于内燃机的操作参数的检测值的频谱分析。 以预定的时间间隔对操作参数进行采样，并将采样值转换为数字值。 相对于预定数量的采样值来计算第一和第二元素的强度。 第一元件和第二元件分别对应于包含在检测值中的多个频率分量，并且第二元件的相位与第一元件的相位不同90度。 使用第一元件强度和第二元件强度，与发动机的旋转同步地计算与多个频率分量对应的频率分量强度。 通过将发动机的转速高于或等于的第一元件强度的积分值的一部分和第二元件强度的积分值的一部分分别与相应的先前计算值相对应地计算频率分量强度， 等于设定的阈值。

    Positioning signal reception device and control method of positioning signal reception device
    78.
    发明授权
    Positioning signal reception device and control method of positioning signal reception device 有权

    公开(公告)号：US08619929B2

    公开(公告)日：2013-12-31

    申请号：US12574221

    申请日：2009-10-06

    申请人： Makoto Murakami

    发明人： Makoto Murakami

    IPC分类号： H04B1/10

    CPC分类号： H04B1/7097 ,  G01S19/21 ,  G01S19/30

    摘要： A positioning signal reception device receives a positioning signal transmitted from a position information satellite, and includes: a signal reception portion that obtains a reception signal by receiving the positioning signal; an A/D conversion portion that generates a digital signal by converting the reception signal into a digital form; a filter portion that subjects the digital signal to frequency separation, a characteristic of the filter portion being changeable; a filter characteristic change portion that changes the characteristic of the filter portion according to an operating state of the positioning signal reception device and an external environmental condition of the positioning signal reception device; and a code synchronization establishment portion that establishes synchronization of spreading codes contained in the reception signal.

    Multipath signal determination method, signal suitability determination method, positioning operation method, program, and multipath signal determination circuit
    80.
    发明授权
    Multipath signal determination method, signal suitability determination method, positioning operation method, program, and multipath signal determination circuit 有权
    多路径信号判定方法，信号适应性判定方法，定位运算方法，程序和多径信号判定电路

    公开(公告)号：US08300678B2

    公开(公告)日：2012-10-30

    申请号：US12326347

    申请日：2008-12-02

    申请人： Makoto Murakami

    发明人： Makoto Murakami

    IPC分类号： H04B1/00

    CPC分类号： H04B1/7113 ,  G01S19/22 ,  G01S19/27 ,  G01S19/37 ,  H04B2201/70715

    摘要： A multipath signal determination method includes carrying out correlation operation between a received signal of a positioning signal spread-modulated with a spread code and a replica signal of the spread code with respect to each of IQ components at a predetermined sampling phase interval, and determining whether the received signal is a multipath signal or not, in accordance with a plot position in the case where each correlation value in each of the sampling phases is sequentially plotted on an IQ coordinate.

    摘要翻译： 多路径信号判定方法包括以预定的采样相位间隔对扩频码的扩频调制的接收信号和扩频码的复制信号进行相关运算，并确定是否 根据在每个采样相位中的每个相关值被顺序地绘制在IQ坐标上的情况下的绘图位置，所接收的信号是否为多径信号。