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90 条记录 (耗时 0.03 秒)

    Process for the preparation of ziprasidone
    72.
    发明授权
    Process for the preparation of ziprasidone 失效
    齐拉西酮制备方法

    公开(公告)号：US08178674B2

    公开(公告)日：2012-05-15

    申请号：US13100833

    申请日：2011-05-04

    申请人： Yatendra Kumar ,  Mohan Prasad ,  Mahivir Singh Khanna ,  Seema Ahuja

    发明人： Yatendra Kumar ,  Mohan Prasad ,  Mahivir Singh Khanna ,  Seema Ahuja

    IPC分类号： C07D417/12 ,  A61K31/496 ,  A61P25/18

    CPC分类号： C07D417/12

    摘要： The invention relates to processes for the preparation of substantially pure ziprasidone. The invention also relates to the preparation of acid addition salts of ziprasidone. More particularly, it relates to the preparation of substantially pure hydrochloride salt of ziprasidone. The invention also relates to pharmaceutical compositions that include the substantially pure ziprasidone or ziprasidone hydrochloride and use of said compositions for treating schizophrenia.

    摘要翻译： 本发明涉及制备基本上纯的齐拉西酮的方法。 本发明还涉及齐拉西酮的酸加成盐的制备。 更具体地说，本发明涉及齐拉西酮基本上纯的盐酸盐的制备。 本发明还涉及药物组合物，其包括基本上纯的齐拉西酮或齐拉昔酮盐酸盐以及所述组合物用于治疗精神分裂症的用途。

    Process for the preparation of aprepitant
    73.
    发明授权
    Process for the preparation of aprepitant 有权
    制备阿司匹林的方法

    公开(公告)号：US08080656B2

    公开(公告)日：2011-12-20

    申请号：US12089297

    申请日：2006-10-05

    申请人： Asok Nath ,  Hiten Sharadchandra Mehta ,  Mohan Prasad

    发明人： Asok Nath ,  Hiten Sharadchandra Mehta ,  Mohan Prasad

    IPC分类号： C07D413/02 ,  C07D295/00

    CPC分类号： C07D265/32 ,  C07D413/06

    摘要： The present invention relates to a highly pure (2R,3S)-4-benzyl-3-(4-fluorophenyl)morpholin-2-yl 3,5-bis(trifluoromethyl)benzoate of Formula II, and a process for its preparation. The present invention further provides a process for preparation of Aprepitant of Formula I or pharmaceutically acceptable salt thereof, using the highly pure compound of Formula II. The present invention also provides a process for preparation of Aprepitant of Formula I or pharmaceutically acceptable salt thereof which comprises of cyclising the compound of Formula VII at elevated temperature, in the absence of solvent.

    摘要翻译： 本发明涉及式II的高纯度（2R，3S）-4-苄基-3-（4-氟苯基）吗啉-2-基3,5-双（三氟甲基）苯甲酸酯及其制备方法。 本发明还提供使用高度纯的式II化合物制备式I的阿维地丁或其药学上可接受的盐的方法。 本发明还提供了制备式I的阿维地敏剂或其药学上可接受的盐的方法，其包括在不存在溶剂的情况下在高温下使式VII的化合物环化。

    Process for the Preparation of Ziprasidone
    76.
    发明申请
    Process for the Preparation of Ziprasidone 审中-公开
    齐拉西酮的制备方法

    公开(公告)号：US20080312254A1

    公开(公告)日：2008-12-18

    申请号：US10598370

    申请日：2005-02-28

    申请人： Yatendra Kumar ,  Mohan Prasad ,  Mahivir Singh Khanna ,  Seema Ahuja

    发明人： Yatendra Kumar ,  Mohan Prasad ,  Mahivir Singh Khanna ,  Seema Ahuja

    IPC分类号： A61K31/501 ,  C07D417/14 ,  A61P25/18

    CPC分类号： C07D417/12

    摘要： The invention relates to processes for the preparation of substantially pure ziprasidone. The invention also relates to the preparation of acid addition salts of ziprasidone. More particularly, it relates to the preparation of substantially pure hydrochloride salt of ziprasidone. The invention also relates to pharmaceutical compositions that include the substantially pure ziprasidone or ziprasidone hydrochloride and use of said compositions for treating schizophrenia.

    摘要翻译： 本发明涉及制备基本上纯的齐拉西酮的方法。 本发明还涉及齐拉西酮的酸加成盐的制备。 更具体地说，本发明涉及齐拉西酮基本上纯的盐酸盐的制备。 本发明还涉及药物组合物，其包括基本上纯的齐拉西酮或齐拉昔酮盐酸盐以及所述组合物用于治疗精神分裂症的用途。

    Polymorphs of s-omeprazole
    77.
    发明申请
    Polymorphs of s-omeprazole 审中-公开
    s-奥美拉唑的多晶型物

    公开(公告)号：US20060247277A1

    公开(公告)日：2006-11-02

    申请号：US10546887

    申请日：2004-03-01

    申请人： Yatendra Kumar ,  Mahavir Khanna ,  Mohan Prasad

    发明人： Yatendra Kumar ,  Mahavir Khanna ,  Mohan Prasad

    IPC分类号： A61K31/4439 ,  C07D403/02

    CPC分类号： A61K31/4439

    摘要： This invention relates to polymorphic forms of the S-enantiomer of omeprazole which is S-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1Hbenzimidazole. The invention also relates to processes for preparing the polymorphic forms. More particularly, it relates to the preparation of two polymorphic forms of Someprazole, referred to as ‘Form I’ and ‘Form 1’ and pharmaceutical compositions that include the ‘Form I’ and ‘Form II’.

    摘要翻译： 本发明涉及奥美拉唑S-对映异构体的多晶型物，其为S-5-甲氧基-2 - [[（4-甲氧基-3,5-二甲基-2-吡啶基） - 甲基]亚磺酰基] -1H-苯并咪唑。 本发明还涉及制备多晶型物的方法。 更具体地说，本发明涉及称为“形式I”和“形式1”的两种多形态的索吡拉唑和包含“I型”和“II型”的药物组合物的制备。