公开(公告)号：US08916713B2

公开(公告)日：2014-12-23

申请号：US13812066

申请日：2011-07-15

Applicant: Pranab Chatterjee ,  Asok Nath ,  Sarbjot Singh Sokhi ,  Mohan Prasad

Inventor： Pranab Chatterjee ,  Asok Nath ,  Sarbjot Singh Sokhi ,  Mohan Prasad

IPC: C07D277/56

CPC classification number: C07D277/56

Abstract: An improved and efficient process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.

Abstract translation: 提供了一种改进和有效的制备基本上不含酰胺副产物的2- [3-氰基-4-（2-甲基丙氧基）苯基] -4-甲基噻唑-5-羧酸（febustostat）的方法。

公开(公告)号：US20120178821A1

公开(公告)日：2012-07-12

申请号：US13388134

申请日：2010-07-30

Applicant: Pranab Chatterjee ,  Asok Nath ,  Mohan Prasad

Inventor： Pranab Chatterjee ,  Asok Nath ,  Mohan Prasad

IPC: A61K31/138 ,  C07C59/265

CPC classification number: C07C217/18 ,  C07C59/265 ,  C07C213/08 ,  C07C213/10

Abstract: The present invention provides a polymorphic form of toremifene citrate and processes for its preparation. It also relates to an improved process for the preparation of the Z isomer of the toremifene base, free of E isomer, and its pharmaceutically acceptable salts.

Abstract translation: 本发明提供了一种多晶型托伐米芬柠檬酸盐及其制备方法。 本发明还涉及制备不含E异构体的托瑞米芬碱的Z异构体及其药学上可接受的盐的改进方法。

公开(公告)号：US20130245278A1

公开(公告)日：2013-09-19

申请号：US13812066

申请日：2011-07-15

Applicant: Pranab Chatterjee ,  Asok Nath ,  Sarbjot Singh Sokhi ,  Mohan Prasad

Inventor： Pranab Chatterjee ,  Asok Nath ,  Sarbjot Singh Sokhi ,  Mohan Prasad

IPC: C07D277/56

CPC classification number: C07D277/56

Abstract: An improved and efficient process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.

Abstract translation: 提供了一种改进和有效的制备基本上不含酰胺副产物的2- [3-氰基-4-（2-甲基丙氧基）苯基] -4-甲基噻唑-5-羧酸（febustostat）的方法。