公开(公告)号：US5312389A

公开(公告)日：1994-05-17

申请号：US863649

申请日：1992-04-03

申请人： Felix Theeuwes ,  Su Il Yum

发明人： Felix Theeuwes ,  Su Il Yum

IPC分类号： A61K9/22 ,  A61M5/145 ,  A61M5/155

CPC分类号： A61M5/155 ,  A61M5/1452 ,  A61M2005/14513

摘要： An osmotically driven syringe (20, 60) is disclosed which can be used to deliver a beneficial agent such as a drug, at varying pre-determined rates over multiple periods of time. The syringe (20, 60) is driven by an osmotic engine (10) having a shaped wall (12) containing an osmotic agent (17) and/or a gas generating means (19), such as an effervescent couple. The wall (12) is composed of a semipermeable and/or microporous material which is permeable to an external liquid (e.g., water) but which is substantially impermeable to the osmotic agent (17) and the gas generated by the gas generating means (19). The wall (12) has a passageway (13) therethrough to provide a flow path for the driving fluid generated by the engine (10). The osmotic agent(s) (17) and/or the gas generating means (19) are placed in the engine (10) in such a way as to drive engine (10) at different pumping rates (R.sub.1, R.sub.2) over sequential periods of time (t.sub.0 to t.sub.1 and t.sub.1 to t.sub.2).

摘要翻译： 公开了一种渗透驱动的注射器（20,60），其可以用于在多个时间段内以变化的预定速率递送有益剂例如药物。 注射器（20,60）由渗透引擎（10）驱动，渗透引擎（10）具有包含渗透剂（17）的成形壁（12）和/或诸如泡腾对之类的气体发生装置（19）。 壁（12）由半渗透和/或微孔材料组成，该材料可透过外部液体（例如水），但是渗透剂（17）和由气体发生装置（19）产生的气体基本上是不可渗透的 ）。 壁（12）具有穿过其中的通道（13），以为由发动机（10）产生的驱动流体提供流路。 渗透剂（17）和/或气体发生装置（19）以这样的方式被放置在发动机（10）中，以便在不同的泵送速率（R1，R2）上连续驱动发动机（10） 的时间（t0至t1和t1至t2）。

公开(公告)号：US5250028A

公开(公告)日：1993-10-05

申请号：US741477

申请日：1991-08-09

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M5/14 ,  A61M37/00

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion using permeation enhancers and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。 透皮型药物输送装置粘附在半透膜/微孔壁部分上。 药物由输送装置通过使用渗透促进剂的壁部分输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。 多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。

公开(公告)号：US5232438A

公开(公告)日：1993-08-03

申请号：US898618

申请日：1992-06-15

申请人： Felix Theeuwes ,  J. Richard Gyory ,  Ronald P. Haak

发明人： Felix Theeuwes ,  J. Richard Gyory ,  Ronald P. Haak

IPC分类号： A61N1/30

CPC分类号： A61N1/0444

摘要： A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.

摘要翻译： 一种膜，当没有电流流动时能够抑制剂量从递送系统释放，并且对电辅助剂递送提供最小的阻抗，对于并入电转运剂递送系统和用于体外测定中的测定剂释放速率是有用的 。

公开(公告)号：US5203768A

公开(公告)日：1993-04-20

申请号：US735126

申请日：1991-07-24

申请人： Ronald P. Haak ,  Felix Theeuwes ,  J. Richard Gyory

发明人： Ronald P. Haak ,  Felix Theeuwes ,  J. Richard Gyory

IPC分类号： A61K9/00 ,  A61N1/30

CPC分类号： A61N1/0448 ,  A61K9/0009 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0444

摘要： A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.

摘要翻译： 提供具有活性药物储存器（24）和被动药物储存器（26）的透皮药物递送装置（20）。 药物通过离子电渗从活性药物储存器（24）通过由电源（21）产生的电场积极递送。 同时，药物通过被动（即非电辅助）扩散从被动储存器（26）输送。 在一个实施例中，被动药物储存器（26）与活性药物贮存器（24）电绝缘。 在第二实施方案中，活性和被动药物都包含在相同的储存器（34）中。 在第二实施方案中，活性药物是可离子化的，而被动药物是不可离子化的。 最优选地，活性药物是被动药物的可离子化形式（即盐形式）。

公开(公告)号：US5006346A

公开(公告)日：1991-04-09

申请号：US350482

申请日：1989-05-11

申请人： David E. Edgren ,  Felix Theeuwes

发明人： David E. Edgren ,  Felix Theeuwes

IPC分类号： A61K9/00 ,  A61K9/28 ,  A61K9/36

CPC分类号： A61K9/0004 ,  A61K9/2866 ,  A61K9/2886

摘要： A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.

摘要翻译： 公开了包含围绕药物的外套的剂型。 该涂层包括底涂层和外涂层热退火以在药物周围提供单一的单一涂层。

公开(公告)号：US4994031A

公开(公告)日：1991-02-19

申请号：US338691

申请日：1989-04-17

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

摘要翻译： 公开了一种配制腔，其包括围绕包含用于递送有益剂的装置的内腔的壁。 腔室具有用于允许流体进入腔室的入口和用于使药剂制剂离开腔室的出口。 腔室适用于静脉输送系统，用于将药剂配制物递送给患者。

公开(公告)号：US4985016A

公开(公告)日：1991-01-15

申请号：US311905

申请日：1989-02-15

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M39/00 ,  A61M5/14

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。 透皮型药物输送装置粘附在半透膜/微孔壁部分上。 药物由输送装置通过壁部分输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。 多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。

公开(公告)号：US4871360A

公开(公告)日：1989-10-03

申请号：US854452

申请日：1986-04-21

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A formulation chamber is disclosed comprising a wall surrounding a space containing a beneficial agent. The formulation chamber has an inlet for admitting a fluid into the chamber and an outlet for letting the fluid containing the agent leave the chamber. The chamber can additionally comprise a film for regulating the rate of release from the chamber, and optionally a filter. The chamber is adapted for use in an intraveous delivery system for delivering the fluid containing the agent to a patient. A method also is disclosed for using the formulation chamber.

摘要翻译： 公开了一种配制腔，其包括围绕包含有益剂的空间的壁。 制剂腔室具有用于将流体进入腔室的入口和用于使含有药剂的流体离开腔室的出口。 该室还可以包括用于调节从室释放的速率的膜，以及可选的过滤器。 该腔室适用于内部输送系统，用于将含有药剂的流体输送给患者。 公开了一种使用制剂室的方法。

公开(公告)号：US4863744A

公开(公告)日：1989-09-05

申请号：US26236

申请日：1987-03-16

申请人： John Urquhart ,  Felix Theeuwes

发明人： John Urquhart ,  Felix Theeuwes

IPC分类号： A61K9/20

CPC分类号： A61K9/2081

摘要： A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.

摘要翻译： 公开了用于将试剂递送到pH大于3.5的所选择的使用环境的递送系统。

公开(公告)号：US4857052A

公开(公告)日：1989-08-15

申请号：US45358

申请日：1987-05-04

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

摘要翻译： 公开了一种配制腔，其包括围绕包含用于递送有益剂的装置的内腔的壁。 腔室具有用于允许流体进入腔室的入口和用于使药剂制剂离开腔室的出口。 腔室适用于静脉输送系统，用于将药剂配制物递送给患者。