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公开(公告)号:US20080057056A1
公开(公告)日:2008-03-06
申请号:US11841718
申请日:2007-08-20
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
CPC分类号: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcgammaRIIc具有增加的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽和使用优化的Fc变体的方法。
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公开(公告)号:US20070286859A1
公开(公告)日:2007-12-13
申请号:US11766581
申请日:2007-06-21
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having decreased affinity for FcγRI, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRRI具有降低的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽和使用优化的Fc变体的方法。
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公开(公告)号:US20070237767A1
公开(公告)日:2007-10-11
申请号:US11766624
申请日:2007-06-21
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having decreased affinity for FcγRIIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRIIIa具有降低的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。
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公开(公告)号:US20070237766A1
公开(公告)日:2007-10-11
申请号:US11765402
申请日:2007-06-19
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRIIIa具有增加的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。
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公开(公告)号:US20070231329A1
公开(公告)日:2007-10-04
申请号:US11764001
申请日:2007-06-15
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRIIb具有增加的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。
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