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177 条记录 (耗时 0.034 秒)

    Aryl-oxo-heptenoic acids
    72.
    发明授权
    Aryl-oxo-heptenoic acids 失效
    芳基 - 氧代 - 庚烯酸

    公开(公告)号：US3956374A

    公开(公告)日：1976-05-11

    申请号：US466667

    申请日：1974-05-03

    申请人： Kenneth L. Shepard ,  Edward J. Cragoe, Jr. ,  Wasyl Halczenko

    发明人： Kenneth L. Shepard ,  Edward J. Cragoe, Jr. ,  Wasyl Halczenko

    IPC分类号： C07C59/76 ,  C07C51/00 ,  C07C59/88 ,  C07C59/90 ,  C07C67/00 ,  C07C63/00

    CPC分类号： C07C45/68 ,  C07C45/74 ,  C07C59/88 ,  C07C59/90 ,  Y10S514/907

    摘要： Novel 4-phenyl-4-substituted-5-oxo-7-aryl-heptanoic acids are prefaced by either of two synthetic processes. The first method involves the reaction of a 4-phenyl-4-substituted-5-oxo-hexanoic acid with an arylcarboxyaldehyde. The second method involves reaction of an arylcarboxaldehyde with an appropriate ketone, treatment of the product with an acrylic acid ester, followed by hydrolysis of the resulting ester. The compounds of the invention are prostaglandin antagonists and are particularly useful as topical anti-inflammatory agents.

    摘要翻译： 新的4-苯基-4-取代-5-氧代-7-芳基 - 庚酸由两种合成方法中的任一种开始。 第一种方法涉及4-苯基-4-取代-5-氧代 - 己酸与芳基羧甲醛的反应。 第二种方法包括使芳基甲醛与适当的酮反应，用丙烯酸酯处理产物，然后水解所得的酯。 本发明的化合物是前列腺素拮抗剂，并且特别可用作局部抗炎剂。

    Amides of [(5,6-dichloro-3-oxo-9-alpha-substituted-2,3,9,9-alpha-tetrahydrofluoren -7-yl-oxyl]acetic acids, and pharmaceutical compositions thereof
    74.
    发明授权
    Amides of [(5,6-dichloro-3-oxo-9-alpha-substituted-2,3,9,9-alpha-tetrahydrofluoren -7-yl-oxyl]acetic acids, and pharmaceutical compositions thereof 失效
    [（5,6-二氯-3-氧代-9-α-取代-2,3,9,9-α-四氢芴-7-基氧基]乙酸的酰胺及其药物组合物

    公开(公告)号：US4782073A

    公开(公告)日：1988-11-01

    申请号：US946544

    申请日：1986-12-24

    申请人： Edward J. Cragoe, Jr.

    发明人： Edward J. Cragoe, Jr.

    IPC分类号： C07C311/51 ,  C07D207/16 ,  C07D233/54 ,  C07D257/06 ,  A61K31/41

    CPC分类号： C07D233/64 ,  C07C311/51 ,  C07D207/16 ,  C07D257/06 ,  C07C2103/18

    摘要： The invention relates to novel amides of [(5,6-dichloro-3-oxo-9a-substituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy]acetic acids, their derivatives, and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, the neurological problems caused by AIDS, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydroephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.

    摘要翻译： 本发明涉及[（5,6-二氯-3-氧代-9a-取代-2,3,9,9a-四氢芴-7-基）氧]乙酸的新型酰胺及其衍生物及其盐。 这些化合物可用于治疗和预防脑损伤以及头部创伤，中风（特别是缺血性），呼吸停止，心脏停搏，雷氏综合症，脑血栓形成，脑栓塞，艾滋病引起的神经系统问题， 脑出血，脑肿瘤，脑脊髓炎，脊髓损伤，水肿，手术后脑损伤创伤，脑部感染引起的水肿，各种脑震荡和颅内压升高。

    Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, their derivatives and their salts
    75.
    发明授权
    Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, their derivatives and their salts 失效
    取代的（2,3-二氢-1-氧代-1H-茚-5-基）链烷酸，其衍生物及其盐

    公开(公告)号：US4754061A

    公开(公告)日：1988-06-28

    申请号：US928748

    申请日：1986-11-10

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07C59/86 ,  C07C59/88

    CPC分类号： C07C59/86 ,  C07C59/88

    摘要： The invention relates to novel substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代的（2,3-二氢-1-氧代-1H-茚-5-基）链烷酸及其衍生物及其盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    Ester and amide substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy)alkanoic acids and their salts
    78.
    发明授权
    Ester and amide substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy)alkanoic acids and their salts 失效
    酯和酰胺取代的（2,3-二氢-4-（3-氧代-1-环己烯-1-基）苯氧基）链烷酸及其盐

    公开(公告)号：US4719310A

    公开(公告)日：1988-01-12

    申请号：US812671

    申请日：1985-12-23

    申请人： Adolph M. Pietruszkiewicz ,  Otto W. Woltersdorf, Jr. ,  Edward J. Cragoe, Jr.

    发明人： Adolph M. Pietruszkiewicz ,  Otto W. Woltersdorf, Jr. ,  Edward J. Cragoe, Jr.

    IPC分类号： C07C59/68 ,  C07C69/76

    CPC分类号： C07C59/68

    摘要： The invention relates to novel ester and amide substituted [2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy]alkanoic acids and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的酯和酰胺取代的[2,3-二氢-4-（3-氧代-1-环己烯-1-基）苯氧基]链烷酸及其盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。