摘要:
A NOVEL CLASS OF MONOMERIC EMULSION STABILIZERS CONSISTS OF CERTAIN TYPES OF ETHYLENICALLY-UNSATURATED RADICALS COVALENTLY LINKED TO A QUATERNARY NITROGEN ATOM WHICH IN TURN IS COVALENTLY LINKED TO A LIPOPHILIC RADICAL. SUCH MONOMERS WILL POLYMERIZE WITH OTHER ETHYLENICALLY-UNSATURATED RADICALS FORMING SELF-STABILIZED, SURFACTANT-FREE POLYMERIC DISPERSIONS.
摘要:
Compounds of the formula ##STR1## wherein R is (a) optionally-substituted and optionally-hydrogenated biphenylyl, (b) optionally-substituted and optionally-hydrogenated bicyclic aryl having from 8 to 12 ring carbon atoms or (c) a radical of the formula ##STR2## R.sup.1 is aliphatic hydrocarbyl, alicyclic hydrocarbyl or optionally-substituted phenyl;R.sup.2 is --H or lower aliphatic hydrocarbyl;R.sup.3 is --H, lower alkyl, cycloalkyl, optionally-substituted phenyl or, with R.sup.4, alkylene;R.sup.4 is lower alkyl, cycloalkyl, optionally-substituted phenyl, optionally-(nuclearly)-substituted phenalkyl or, with R.sup.3, alkylene;or R.sup.2,R.sup.3 and R.sup.4, together with the carbon to which each is bound, are adamantyl; andn is 3, 4 or 5;and salts thereof with a base are pharmacologically active. Esters thereof are valuable intermediates for the preparation of the pharmacologically-active compounds. Physiologically-acceptable embodiments are administered, e.g., in the form of an appropriate pharmaceutical composition to warm-blooded animals for protection against and treatment for stomach, intestine, pancreas, bile and liver disorders. Syntheses of pharmacologically-active components, transforming toxic embodiments to physiologically-acceptable principles, compounding such principles into pharmaceutical compositions and using such principles for preventing and treating the noted disorders are discussed.
WHEREIN X IS HALOGEN; R1 AND R3 AREALKYL; R2 IS SELECTED FROM THE GROUP CONSISTING OF ALKYL AND ALKOXY; R4 IS SELECTED FROM THE GROUP CONSISTING OF ALKYL, ALKENYL, ALKOXY, ALKYLTHIO AND
((Z)N,(H)(5-N)-PHENYL)-(A)M-
WHEREIN A IS SELECTED FRO THE GROUP CONSISTING OF OXYGEN, SULFUR AND ALKYLENE; Z IS SELECTED FROM THE GROUP CONSISTING OF ALKYL, ALKENYL, ALKOXY, ALKYLTHIO, HALOGEN, NITRO, CYANO AND DIALKYLAMINO; M IS AN INTEGER FROM 0 TO 1; AND N IS AN INTEGER ROM 0 TO 5. THE COMPOUNDS OF THE ABOVE DIESCRIPTION POSSESS VALUABLE ACARICIDAL PROPERTIES.
摘要:
Fluoro substituted aryl esters and thiolesters of amino acids, intermediates therefor, synthesis thereof and the use of said esters and thiolesters and compositions for the control of pests.
摘要:
Novel substituted aromatic aliphatic amino carboxylic acids containing a tertiary nitrogen atom such as 3-[N-ethyl-[1-methyl-2-(4-methoxyphenyl)] ethylamino] -1-propane carboxylic acid ethyl ester or 7-[N-ethyl-[1-methyl-2-(4-methoxyphenyl)] ethylamino] -1-heptane carboxylic acid ethyl ester have been found to be useful spasmolytic agents.
摘要:
The invention relates to 1-aminomethyl-2,2-diaryl cyclopropane carboxamides of the general formula ##SPC1##In which R represents the hydrogen atom, a halogen atom or a lower alkyl group or a lower alkoxy group; R.sub.1 and R.sub.2 which may be the same or different each represent a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, in addition to which R.sub.1 and R.sub.2 together can form with the nitrogen atom to which they are attached a heterocyclic group with 5 to 7 peaks capable of containing a second hetero atom and capable of being substituted, and to their addition salts as new industrial products.These products are suitable for therapeutic application, in particular in the treatment of Parkinson's disease.
摘要翻译:本发明涉及通式为I的1-氨基甲基-2,2-二芳基环丙烷甲酰胺,其中R代表氢原子,卤原子或低级烷基或低级烷氧基; R 1和R 2可以相同或不同,分别表示氢原子,低级烷基,芳基或芳烷基,R 1和R 2可以与它们所连接的氮原子一起形成杂环 具有能够含有第二杂原子并能够被取代的5至7个峰,以及作为新工业产物的其加成盐。
摘要:
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula ##STR2## wherein R.sup.1 is hydrogen or fluorine, R.sup.2 is hydrogen, C.sub.1-6 alkyl, halogen or trifluoromethyl; or W is a phenoxymethyl or benzofuran-2-yl group;R.sup.3 is C.sub.1-12 alkyl or phenyl C.sub.1-6 alkyl;A is hydrogen or methyl,X is carboxy, --Z--CO.sub.2 H, --Z--OH, T--Z--CO.sub.2 H,--Z--NR.sup.4 R.sup.5, --T--Y--OM, --T--Y--NR.sup.4 R.sup.5, or --T--R.sup.6, in the para- or meta-position with respect to the --(CH.sub.2).sub.n group, whereinR.sup.4 and R.sup.5 are each hydrogen or C.sub.1-6 alkyl,R.sup.6 is C.sub.1-6 alkyl,T is 0, S, --NH or --N--R.sup.7, in which R.sup.7 is C.sub.1-6 alkylZ is C.sub.1-10 straight or branched alkylene optionally containing a carbon-carbon double bond;Y is C.sub.2-10 straight or branched alkylene, provided that the hetero atoms in --T--Y--OM and --T--Y--NR.sup.4 R.sup.5 are separated by at least two carbon atoms, M is hydrogen, C.sub.1-6 alkyl or phenyl, and n is 1 or 2, is useful for obesity or hyperglycaemia.
摘要:
This invention is directed to diphenyl ethers having in the 3' position a radical of the formula: ##STR1## The products are prepared by reacting a 3'-halocarbonyl compound with an appropriately substituted oxime. These compounds and their agronomically acceptable salts and compositions containing these compounds as active ingredients are selective herbicides.
摘要:
3-Amino-N-substituted succinamic acids, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and also exhibit pharmacological, e.g. anti-inflammatory, properties.