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13 条记录 (耗时 0.012 秒)

    Monomeric emulsion stabilizers
    1.
    发明授权
    Monomeric emulsion stabilizers 失效
    单体乳化稳定剂

    公开(公告)号：US3780092A

    公开(公告)日：1973-12-18

    申请号：US3780092D

    申请日：1969-10-20

    申请人： KENDALL & CO

    发明人： SAMOUR C ,  RICHARDS M

    IPC分类号： C08F2/28 ,  C07C101/12 ,  C07C101/16 ,  C07C101/20

    CPC分类号： C08F2/28

    摘要： A NOVEL CLASS OF MONOMERIC EMULSION STABILIZERS CONSISTS OF CERTAIN TYPES OF ETHYLENICALLY-UNSATURATED RADICALS COVALENTLY LINKED TO A QUATERNARY NITROGEN ATOM WHICH IN TURN IS COVALENTLY LINKED TO A LIPOPHILIC RADICAL. SUCH MONOMERS WILL POLYMERIZE WITH OTHER ETHYLENICALLY-UNSATURATED RADICALS FORMING SELF-STABILIZED, SURFACTANT-FREE POLYMERIC DISPERSIONS.

    Acylhydrocarbylaminoalkanoic acids, compositions and uses
    3.
    发明授权
    Acylhydrocarbylaminoalkanoic acids, compositions and uses 失效
    酰基烃基氨基链烷酸，组合物和用途

    公开(公告)号：US4243678A

    公开(公告)日：1981-01-06

    申请号：US969701

    申请日：1978-12-15

    申请人： Walter Krastinat

    发明人： Walter Krastinat

    IPC分类号： A01N37/12 ,  C07C233/46 ,  C07K5/02 ,  C07C101/04 ,  C07C101/16 ,  C07C101/44

    CPC分类号： C07C233/46 ,  A01N37/12 ,  C07K5/02

    摘要： Compounds of the formula ##STR1## wherein R is (a) optionally-substituted and optionally-hydrogenated biphenylyl, (b) optionally-substituted and optionally-hydrogenated bicyclic aryl having from 8 to 12 ring carbon atoms or (c) a radical of the formula ##STR2## R.sup.1 is aliphatic hydrocarbyl, alicyclic hydrocarbyl or optionally-substituted phenyl;R.sup.2 is --H or lower aliphatic hydrocarbyl;R.sup.3 is --H, lower alkyl, cycloalkyl, optionally-substituted phenyl or, with R.sup.4, alkylene;R.sup.4 is lower alkyl, cycloalkyl, optionally-substituted phenyl, optionally-(nuclearly)-substituted phenalkyl or, with R.sup.3, alkylene;or R.sup.2,R.sup.3 and R.sup.4, together with the carbon to which each is bound, are adamantyl; andn is 3, 4 or 5;and salts thereof with a base are pharmacologically active. Esters thereof are valuable intermediates for the preparation of the pharmacologically-active compounds. Physiologically-acceptable embodiments are administered, e.g., in the form of an appropriate pharmaceutical composition to warm-blooded animals for protection against and treatment for stomach, intestine, pancreas, bile and liver disorders. Syntheses of pharmacologically-active components, transforming toxic embodiments to physiologically-acceptable principles, compounding such principles into pharmaceutical compositions and using such principles for preventing and treating the noted disorders are discussed.

    摘要翻译： 其中R是（a）任选取代的和任选氢化的联苯基，（b）任选取代的和任选氢化的具有8至12个环碳原子的双环芳基或（c） R1是脂族烃基，脂环烃基或任选取代的苯基; R2是-H或低级脂族烃基; R3是-H，低级烷基，环烷基，任选取代的苯基，或与R4，亚烷基; R 4是低级烷基，环烷基，任选取代的苯基，任选的（核）取代的苯基烷基，或与R3，亚烷基; 或R 2，R 3和R 4与各自结合的碳一起为金刚烷基; n为3,4或5; 并且其与碱的盐具有药理活性。 其酯是制备药理活性化合物的有价值的中间体。 生理上可接受的实施方案例如以适当的药物组合物的形式施用于温血动物，用于保护和治疗胃，肠，胰腺，胆汁和肝脏疾病。 讨论了药理学活性成分的合成，将毒性实施方案转化为生理上可接受的原则，将这些原理复合成药物组合物并使用这些原则来预防和治疗所述病症。

    N-acylated benzohydroxamates
    4.
    发明授权
    N-acylated benzohydroxamates 失效
    N-乙酰苯甲酸酯

    公开(公告)号：US3649664A

    公开(公告)日：1972-03-14

    申请号：US3649664D

    申请日：1968-10-08

    申请人： VELSICOL CHEMICAL CORP

    发明人： RICHTER SIDNEY B ,  BARNAS EUGENE F

    IPC分类号： A01N37/52 ,  C07C101/16 ,  C07C119/00

    CPC分类号： A01N37/52

    摘要： THIS INVENTION DISCLOSES NEW CHEMICAL COMPOUNDS SEJECTED FROM THE GROUP CONSISTING OF

    1-(R3-O-N(-CO-R4)-CO-),2-(R1-O-),3-X,6-R2-BENZENE

    AND THEIR ISOMERIC FROM

    1-(R3-O-N=C(-OOC-R4)-),2-(R''-O-),3-X,6-R2-BENZENE

    WHEREIN X IS HALOGEN; R1 AND R3 AREALKYL; R2 IS SELECTED FROM THE GROUP CONSISTING OF ALKYL AND ALKOXY; R4 IS SELECTED FROM THE GROUP CONSISTING OF ALKYL, ALKENYL, ALKOXY, ALKYLTHIO AND

    ((Z)N,(H)(5-N)-PHENYL)-(A)M-

    WHEREIN A IS SELECTED FRO THE GROUP CONSISTING OF OXYGEN, SULFUR AND ALKYLENE; Z IS SELECTED FROM THE GROUP CONSISTING OF ALKYL, ALKENYL, ALKOXY, ALKYLTHIO, HALOGEN, NITRO, CYANO AND DIALKYLAMINO; M IS AN INTEGER FROM 0 TO 1; AND N IS AN INTEGER ROM 0 TO 5. THE COMPOUNDS OF THE ABOVE DIESCRIPTION POSSESS VALUABLE ACARICIDAL PROPERTIES.

    1-Aminomethyl-2,2-diaryl-cyclopropane carboxamides
    7.
    发明授权
    1-Aminomethyl-2,2-diaryl-cyclopropane carboxamides 失效
    1-氨基甲基-2,2-二芳基 - 环丙烷甲酰胺

    公开(公告)号：US3989722A

    公开(公告)日：1976-11-02

    申请号：US417129

    申请日：1973-11-19

    申请人： Jean-Claude Cognacq

    发明人： Jean-Claude Cognacq

    IPC分类号： C07C217/74 ,  A61K31/13 ,  A61K31/16 ,  A61K31/33 ,  A61P9/00 ,  C07C67/00 ,  C07C213/00 ,  C07C231/00 ,  C07C231/06 ,  C07C233/00 ,  C07C237/24 ,  C07D295/04 ,  C07D295/12 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07C101/12 ,  C07C101/14 ,  C07C101/16 ,  C07D307/62

    CPC分类号： C07D295/155 ,  C07C255/00

    摘要： The invention relates to 1-aminomethyl-2,2-diaryl cyclopropane carboxamides of the general formula ##SPC1##In which R represents the hydrogen atom, a halogen atom or a lower alkyl group or a lower alkoxy group; R.sub.1 and R.sub.2 which may be the same or different each represent a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, in addition to which R.sub.1 and R.sub.2 together can form with the nitrogen atom to which they are attached a heterocyclic group with 5 to 7 peaks capable of containing a second hetero atom and capable of being substituted, and to their addition salts as new industrial products.These products are suitable for therapeutic application, in particular in the treatment of Parkinson's disease.

    摘要翻译： 本发明涉及通式为I的1-氨基甲基-2,2-二芳基环丙烷甲酰胺，其中R代表氢原子，卤原子或低级烷基或低级烷氧基; R 1和R 2可以相同或不同，分别表示氢原子，低级烷基，芳基或芳烷基，R 1和R 2可以与它们所连接的氮原子一起形成杂环 具有能够含有第二杂原子并能够被取代的5至7个峰，以及作为新工业产物的其加成盐。

    Secondary amines and use in pharmaceutical compositions
    8.
    发明授权
    Secondary amines and use in pharmaceutical compositions 失效
    仲胺并用于药物组合物

    公开(公告)号：US4629737A

    公开(公告)日：1986-12-16

    申请号：US513869

    申请日：1983-07-14

    申请人： Barrie C. C. Cantello

    发明人： Barrie C. C. Cantello

    IPC分类号： A61K31/135 ,  A61K31/19 ,  C07C43/225 ,  C07C43/303 ,  C07C43/313 ,  C07C229/38 ,  C07D307/81 ,  C07C101/16 ,  A61K31/195 ,  A61K31/215 ,  C07C101/447

    CPC分类号： C07C255/00 ,  C07C229/38 ,  C07C43/225 ,  C07C43/303 ,  C07C43/313 ,  C07D307/81

    摘要： A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula ##STR2## wherein R.sup.1 is hydrogen or fluorine, R.sup.2 is hydrogen, C.sub.1-6 alkyl, halogen or trifluoromethyl; or W is a phenoxymethyl or benzofuran-2-yl group;R.sup.3 is C.sub.1-12 alkyl or phenyl C.sub.1-6 alkyl;A is hydrogen or methyl,X is carboxy, --Z--CO.sub.2 H, --Z--OH, T--Z--CO.sub.2 H,--Z--NR.sup.4 R.sup.5, --T--Y--OM, --T--Y--NR.sup.4 R.sup.5, or --T--R.sup.6, in the para- or meta-position with respect to the --(CH.sub.2).sub.n group, whereinR.sup.4 and R.sup.5 are each hydrogen or C.sub.1-6 alkyl,R.sup.6 is C.sub.1-6 alkyl,T is 0, S, --NH or --N--R.sup.7, in which R.sup.7 is C.sub.1-6 alkylZ is C.sub.1-10 straight or branched alkylene optionally containing a carbon-carbon double bond;Y is C.sub.2-10 straight or branched alkylene, provided that the hetero atoms in --T--Y--OM and --T--Y--NR.sup.4 R.sup.5 are separated by at least two carbon atoms, M is hydrogen, C.sub.1-6 alkyl or phenyl, and n is 1 or 2, is useful for obesity or hyperglycaemia.

    摘要翻译： 式（I）的化合物：其中：W是任选取代的下式的苯基，其中R 1是氢或氟，R 2是 氢，C 1-6烷基，卤素或三氟甲基; 或W是苯氧基甲基或苯并呋喃-2-基; R3是C1-12烷基或苯基C1-6烷基; A是氢或甲基，X是羧基，-Z-CO 2 H，-Z-OH，TZ-CO 2 H，-Z-NR 4 R 5，-TY-OM，-TY-NR 4 R 5或-T- 相对于 - （CH 2）n基的间位，其中R 4和R 5各自为氢或C 1-6烷基，R 6为C 1-6烷基，T为0，S，-NH或-N-R 7，其中 R 7是C 1-6烷基Z是任选含有碳 - 碳双键的C 1-10直链或支链亚烷基; Y是C2-10直链或支链亚烷基，条件是-TY-OM和-TY-NR4R5中的杂原子被至少两个碳原子分开，M是氢，C 1-6烷基或苯基，n是1或 2，可用于肥胖或高血糖。