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公开(公告)号：US11298889B2
公开(公告)日：2022-04-12
申请号：US16294761
申请日：2019-03-06
发明人： Itai Pelled , Elena Sherman , Eran Goldberg , Kevin D. Rupp , Noam Nir
摘要： An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
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公开(公告)号：US20210369452A1
公开(公告)日：2021-12-02
申请号：US17399966
申请日：2021-08-11
发明人： Noam Nir , Elena Sherman , Michael Bukin , Tomer Saar
IPC分类号： A61F2/24
摘要： An implantable prosthetic valve assembly, according to one embodiment, comprises a frame assembly including a plurality of struts and a prosthetic valve secured inside the frame assembly by sutures. The sutures are inward of the outermost surface of an outer periphery of the frame assembly. In certain embodiments the struts contain recesses in which sutures can be disposed. In other embodiments, the struts can have holes through them which the sutures pass through. The implantable prosthetic valve assembly can also be collapsed within a catheter such that an outermost surface of a periphery of the frame assembly touches the catheter but the sutures are spaced apart from the catheter or are flush with the outer surface of the frame.
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公开(公告)号：US20210259833A1
公开(公告)日：2021-08-26
申请号：US17320004
申请日：2021-05-13
发明人： David Maimon , Michael Bukin , Tamir S. Levi , Noam Nir , Ziv Yohanan , Amir Keret , Elena Sherman
IPC分类号： A61F2/24
摘要： A prosthetic heart valve includes an annular frame including a plurality of angled strut members that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The frame has an inflow end and an outflow end, and includes a leaflet structure positioned within the frame, the leaflet structure comprising a plurality of leaflets arranged to form a plurality of commissures. The frame includes a plurality of commissure support elements, each commissure support element being positioned at one of the commissures. Each of the commissure support elements has a coupling portion coupled to the frame and first and second members coupled to the coupling portion and extending in a direction toward the inflow end of the frame or toward the outflow end of the frame. The leaflets of each commissure are received between the first and second members of the respective commissure support element.
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公开(公告)号：US20210128304A1
公开(公告)日：2021-05-06
申请号：US17150355
申请日：2021-01-15
发明人： David Maimon , Noam Nir , Tomer Saar
IPC分类号： A61F2/24
摘要： A method for improving leaflet prolapse and/or valve regurgitation associated with a heart valve involves delivering a spacer device into a ventricle of a heart using a delivery system comprising a catheter, fixing the spacer device to a wall of the ventricle, expanding the spacer device to reposition a papillary muscle disposed in the ventricle away from the wall, the papillary muscle being connected to a leaflet of an atrioventricular heart valve via chordae tendineae, and releasing the spacer device from the catheter.
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公开(公告)号：US20200253731A1
公开(公告)日：2020-08-13
申请号：US16863675
申请日：2020-04-30
发明人： Boaz Manash , Oren Cohen , Noam Nir , Ilan Tamir , Eitan Atias , Ofir Witzman , Michal Aliza Ruchelsman
摘要： Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The delivery system can include a number of advantageous steering and delivery features, in particular for the transseptal delivery approach.
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公开(公告)号：US10646340B2
公开(公告)日：2020-05-12
申请号：US15680030
申请日：2017-08-17
发明人： Boaz Manash , Oren Cohen , Noam Nir , Ilan Tamir , Eitan Atias , Ofir Witzman , Michal Aliza Ruchelsman
摘要： Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The delivery system can include a number of advantageous steering and delivery features, in particular for the transseptal delivery approach.
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公开(公告)号：US10376364B2
公开(公告)日：2019-08-13
申请号：US15344163
申请日：2016-11-04
发明人： Ilan Tamir , Noam Nir , Boaz Manash , David Maimon , Oren Cohen
IPC分类号： A61F2/24
摘要： Disclosed herein are embodiments of delivery capsules for delivering prosthetic implants around the relatively tight bends of a catheter. In particular, disclosed herein are delivery capsules including a tubular layer for holding the heart valve, a frame enclosing the tubular layer and an elongate element coupled to the frame for allowing the tubular layer and frame to expand. For example, the frame may be biased to expand and withdrawal of the elongate element from openings in the frame can release the frame to expand into a larger diameter. Another embodiment includes a helical wire wrapped around the capsule for easy delivery through bends and a second helical wire that is advanced between windings of the first helical wire to selectively stiffen the capsule for withdrawal. Other embodiments include sock-like capsules that can be crumpled into shorter lengths by pulling a pull line attached to the capsule.
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公开(公告)号：US20190105154A1
公开(公告)日：2019-04-11
申请号：US16214561
申请日：2018-12-10
发明人： Hanoch Cohen-Tzemach , Tamir S. Levi , Noam Nir , Bella Felsen
IPC分类号： A61F2/24
摘要： Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.
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公开(公告)号：US20190105153A1
公开(公告)日：2019-04-11
申请号：US16208263
申请日：2018-12-03
发明人： Alexander Barash , Yair A. Neumann , Tomer Saar , Ziv Yohanan , Noam Nir , Michael Bukin , Boaz Manash
IPC分类号： A61F2/24
摘要： In one embodiment, a prosthetic valve can comprise a radially expandable and compressible frame, which can include a plurality of struts which are pivotally joined together without requiring individual rivets. In some embodiments, the struts are interwoven, and can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In another embodiment, the frame comprises a plurality of inner struts and outer struts which are connected by a plurality of chains of interconnected rivets, avoiding the need to provide individual rivets at each junction between struts. In still another embodiment, separate hinges or flanged rivets are provided to interconnect the struts.
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公开(公告)号：US10232564B2
公开(公告)日：2019-03-19
申请号：US15140387
申请日：2016-04-27
发明人： Itai Pelled , Elena Sherman , Eran Goldberg , Kevin D. Rupp , Noam Nir
摘要： The present disclosure relates to laminated sealing members for prosthetic valves and methods of making the same. In a representative embodiment, an implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
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