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公开(公告)号：US11759317B2
公开(公告)日：2023-09-19
申请号：US17071641
申请日：2020-10-15
发明人： Son V. Nguyen , Kevin D. Rupp , Ajay Chadha , Jeff Lindstrom
IPC分类号： A61F2/24 , D03D3/02 , D03D25/00 , D03D15/283
CPC分类号： A61F2/2409 , D03D3/02 , D03D15/283 , D03D25/005 , A61F2/2418 , A61F2210/0019 , A61F2210/0071 , A61F2210/0076 , A61F2220/0075 , A61F2230/0069 , A61F2240/004 , A61F2250/006 , A61F2250/0069 , D10B2509/00
摘要： A docking device includes a hollow cylindrical body portion having an internal surface and an outer surface. The hollow cylindrical body portion is formed of a three-dimensional (3D) woven fabric comprising a plurality of different types of fibers.
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公开(公告)号：US20180168804A1
公开(公告)日：2018-06-21
申请号：US15841046
申请日：2017-12-13
发明人： Son V. Nguyen , Kevin D. Rupp , Ajay Chadha , Jeff Lindstrom
摘要： A docking device for a bioprosthesis is disclosed that can change shape and recover after a deforming stress is removed, that adjusts to surrounding conditions to accommodate different complex anatomic geometries, and that mitigates leakage around the bioprosthesis. The docking device can include a 3D woven fabric forming an internal surface, an outer surface, and a thickness therebetween. A filler can be coupled to the outer surface. A method for making a docking device is also provided. The method includes weaving a 3D woven fabric by interlacing a shape memory material, a low-melt thermoplastic polymer or resin having a melting point, and a high-tenacity biocompatible material; and pressing and heating the 3D woven fabric over a shape-setting mold at temperatures greater than the melting point of the low-melt thermoplastic polymer or resin.
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公开(公告)号：US20240115375A1
公开(公告)日：2024-04-11
申请号：US18542482
申请日：2023-12-15
发明人： Lien Huong Thi Hoang , Son V. Nguyen , Hien Tran Ngo , Vivian Tran , Russell T. Joseph , Dinesh L. Sirimanne , Kevin D. Rupp , Diana Nguyen-Thien-Nhon
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2418 , A61F2230/0006 , A61F2230/0069 , A61F2230/0076
摘要： A prosthetic heart valve includes an annular frame that is radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration. The frame has a plurality of circumferentially extending rows of angled struts, each row of angled struts comprising angled struts arranged in a zig-zag pattern. The prosthetic heart valve further includes a leaflet structure positioned within the frame and secured thereto, and an outer sealing member mounted outside of the frame. The sealing member has an undulating outflow edge portion forming a plurality of triangular projections that are connected to and shaped to correspond to the zig-zag pattern of one of the rows of angled struts. The outer sealing member is sized to fit snugly against the outer surface of the frame when the frame is in the expanded configuration.
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公开(公告)号：US11883281B2
公开(公告)日：2024-01-30
申请号：US17708428
申请日：2022-03-30
发明人： Lien Huong Thi Hoang , Son V. Nguyen , Hien Tran Ngo , Vivian Tran , Russell T. Joseph , Dinesh L. Sirimanne , Kevin D. Rupp , Diana Nguyen-Thien-Nhon
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2418 , A61F2230/0006 , A61F2230/0069 , A61F2230/0076
摘要： A prosthetic heart valve includes an annular frame that has an inflow end and an outflow end and is radially compressible and expandable between a radially compressed configuration and a radially expanded configuration. The prosthetic heart valve further includes a leaflet structure positioned within the frame and secured thereto, and an outer sealing member mounted outside of the frame and adapted to seal against surrounding tissue when the prosthetic heart valve is implanted within a native heart valve annulus of a patient. The sealing member can include a mesh layer and pile layer comprising a plurality of pile yarns extending outwardly from the mesh layer.
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公开(公告)号：US11103345B2
公开(公告)日：2021-08-31
申请号：US16262188
申请日：2019-01-30
发明人： Tamir S. Levi , Ron Sharoni , Elena Sherman , Oren H. Wintner , Kevin D. Rupp , Son V. Nguyen , Ajay Chadha , Jeff Lindstrom
摘要： Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. The prosthetic valve can comprise an annular frame, leaflets, an inner skirt, and an outer skirt. The outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack that buckles outward radially when the valve is in the expanded configuration and which lies flat when the valve is in the collapsed configuration. In some embodiments, the outer skirt is stiffer in the axial direction of the valve than in the circumferential direction of the valve. In additional embodiments, the outer skirt comprises a self-expandable fabric comprising fibers made of a shape memory material having a shape memory set to enhance the radially outward buckling of the outer skirt. Methods of crimping such valves to a collapsed or partially collapsed configuration are also disclosed.
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公开(公告)号：US20200214840A1
公开(公告)日：2020-07-09
申请号：US16820499
申请日：2020-03-16
发明人： Kevin D. Rupp , Tung T. Le , Thanh Huy Le , Brian C. Gray , Alejandro J. Froimovich Rosenberg , Jeff Lindstrom , Kim D. Nguyen , Sonny Tran
IPC分类号： A61F2/24
摘要： A delivery apparatus for implanting a radially compressible and expandable prosthetic heart valve in a native heart valve of the heart includes a handle portion and an elongated shaft extending from and movable relative to the handle portion. The shaft includes a proximal end portion coupled to the handle portion and a distal end portion configured to mount a prosthetic heart valve in a radially compressed state. The handle portion includes a control member movable longitudinally with respect to the handle portion, the control member engaging a gear assembly operable to convert longitudinal motion of the control member to rotational motion of the gear assembly. The gear assembly engages the elongated shaft such that rotational motion of the gear assembly causes corresponding longitudinal motion of the elongated shaft relative to the handle portion.
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公开(公告)号：US20160317305A1
公开(公告)日：2016-11-03
申请号：US15140387
申请日：2016-04-27
发明人： Itai Pelled , Elena Sherman , Eran Goldberg , Kevin D. Rupp , Noam Nir
CPC分类号： B29C66/53245 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2210/0076 , A61F2230/0069 , A61F2240/001 , A61F2250/0069
摘要： The present disclosure relates to laminated sealing members for prosthetic valves and methods of making the same. In a representative embodiment, an implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
摘要翻译： 本公开涉及用于人造瓣的层压密封构件及其制造方法。 在代表性的实施例中，可径向可折叠到收缩构造并且可径向扩张到扩张构造的可植入假体瓣包括具有流入端和流出端的环形框架，定位在框架内并固定到其上的小叶结构， 层压密封件包括封装材料。 层叠密封构件具有封闭框架的至少一部分的主要部分和从框架的流入端延伸的端部，并且层叠密封构件的端部折叠形成邻近流入端的套筒 框架并固定到层压密封件的主要部分。
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公开(公告)号：US11298889B2
公开(公告)日：2022-04-12
申请号：US16294761
申请日：2019-03-06
发明人： Itai Pelled , Elena Sherman , Eran Goldberg , Kevin D. Rupp , Noam Nir
摘要： An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
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公开(公告)号：US10588744B2
公开(公告)日：2020-03-17
申请号：US15252110
申请日：2016-08-30
发明人： Kevin D. Rupp , Tung T. Le , Thanh Huy Le , Brian C. Gray , Alejandro J. Froimovich Rosenberg , Jeff Lindstrom , Kim D. Nguyen , Sonny Tran
摘要： A delivery apparatus for implanting a radially compressible and expandable prosthetic heart valve in a native heart valve of the heart includes a handle portion and an elongated shaft extending from and movable relative to the handle portion. The shaft includes a proximal end portion coupled to the handle portion and a distal end portion configured to mount a prosthetic heart valve in a radially compressed state. The handle portion includes a control member movable longitudinally with respect to the handle portion, the control member engaging a gear assembly operable to convert longitudinal motion of the control member to rotational motion of the gear assembly. The gear assembly engages the elongated shaft such that rotational motion of the gear assembly causes corresponding longitudinal motion of the elongated shaft relative to the handle portion.
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公开(公告)号：US20190159895A1
公开(公告)日：2019-05-30
申请号：US16262188
申请日：2019-01-30
发明人： Tamir S. Levi , Ron Sharoni , Elena Sherman , Oren H. Wintner , Kevin D. Rupp , Son V. Nguyen , Ajay Chadha , Jeff Lindstrom
IPC分类号： A61F2/24
摘要： Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. The prosthetic valve can comprise an annular frame, leaflets, an inner skirt, and an outer skirt. The outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack that buckles outward radially when the valve is in the expanded configuration and which lies flat when the valve is in the collapsed configuration. In some embodiments, the outer skirt is stiffer in the axial direction of the valve than in the circumferential direction of the valve. In additional embodiments, the outer skirt comprises a self-expandable fabric comprising fibers made of a shape memory material having a shape memory set to enhance the radially outward buckling of the outer skirt. Methods of crimping such valves to a collapsed or partially collapsed configuration are also disclosed.
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