公开(公告)号：US20110257547A1

公开(公告)日：2011-10-20

申请号：US13172293

申请日：2011-06-29

申请人： Yunlong Zhang

发明人： Yunlong Zhang

IPC分类号： A61N1/365 ,  A61B5/0402

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3956

摘要： This document discusses, among other things, systems, devices, and methods for measuring cardiac impedances and producing one or more resynchronization index parameters each indicative of a cardiac synchrony or asynchrony using the measured cardiac impedances. In one example, the one or more resynchronization index parameters are used to adjust one or more pacing parameters of a cardiac resynchronization therapy.

摘要翻译： 该文件尤其涉及用于测量心脏阻抗并且产生一个或多个重新同步指数参数的系统，装置和方法，每个指示使用所测量的心脏阻抗的心脏同步或不同步。 在一个示例中，使用一个或多个再同步化指数参数来调整心脏再同步治疗的一个或多个起搏参数。

公开(公告)号：US20100121051A1

公开(公告)日：2010-05-13

申请号：US12527973

申请日：2008-05-12

申请人： Brian Nicholas Cook ,  Anne Bettina Eldrup ,  Ingo Andreas Mugge ,  Fariba Soleymanzadeh ,  Sanxing Sun ,  Yunlong Zhang

发明人： Brian Nicholas Cook ,  Anne Bettina Eldrup ,  Ingo Andreas Mugge ,  Fariba Soleymanzadeh ,  Sanxing Sun ,  Yunlong Zhang

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.

摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，W和Y如本文所述的式（I）化合物，或其互变异构体，前药，溶剂化物或盐。 这些化合物可用作促进罗素素II的抑制剂，因此可用于治疗通过促肾上腺素II与其受体（包括心血管疾病）的相互作用介导或维持的各种疾病和病症。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US20090306486A1

公开(公告)日：2009-12-10

申请号：US12478476

申请日：2009-06-04

申请人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

发明人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

IPC分类号： A61B5/046 ,  A61B5/02 ,  A61B5/0464

CPC分类号： A61B5/0464 ,  A61B5/0215 ,  A61B5/0422 ,  A61B5/046 ,  A61N1/3622 ,  A61N1/3702

摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.

摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路， 到心脏信号感测电路。 所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定是否 快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

公开(公告)号：US20090149719A1

公开(公告)日：2009-06-11

申请号：US12257296

申请日：2008-10-23

申请人： Ramesh Wariar ,  Yunlong Zhang ,  Haresh G. Sachanandani

发明人： Ramesh Wariar ,  Yunlong Zhang ,  Haresh G. Sachanandani

IPC分类号： A61B5/00

CPC分类号： A61B5/0002 ,  A61B5/022 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0531 ,  A61B5/091 ,  A61B5/7275 ,  A61B5/7475 ,  G06F19/3418 ,  G16H10/20

摘要： A system and method for integrating qualitative assessment into remote patient management through a visual analog scale is provided. A query is associated to a physiological condition. A visual analog scale includes a linear gradient and, at each end, descriptors for a range of subjective and continuous responses to the query. Assessment data for a patient is obtained. A medical device of the patient is interrogated and stored data is received. The query is displayed with the visual analog scale. An answer to the query includes a point selected between the ends of and along the linear gradient. A distance of the point from one end of the linear gradient is determined. The distance is quantified as a fixed value in proportion to the distance. A risk to the patient is assessed. The stored data and the fixed value are analyzed against the physiological condition to represent patient wellness.

摘要翻译： 提供了一种通过视觉模拟量表将定性评估整合到远程患者管理中的系统和方法。 查询与生理条件相关联。 视觉模拟量表包括线性梯度，并且在每一端都有一系列对查询的主观和连续响应的描述符。 获得患者的评估数据。 询问患者的医疗装置并接收存储的数据。 查询以视觉模拟量表显示。 查询的答案包括在线性渐变的两端之间选择的点。 确定从线性梯度的一端的点的距离。 距离被量化为与距离成比例的固定值。 评估患者的风险。 根据生理条件分析存储的数据和固定值以表示患者健康。

公开(公告)号：US07496402B2

公开(公告)日：2009-02-24

申请号：US10835078

申请日：2004-04-29

申请人： Yunlong Zhang

发明人： Yunlong Zhang

IPC分类号： A61N1/00

CPC分类号： A61N1/371 ,  A61N1/3622

摘要： A method and system for delivering anti-tachycardia pacing (ATP) is disclosed. During delivery of an ATP burst, an implantable cardiac rhythm management device is programmed to sense evoked responses and determine whether or not the ATP burst has entrained the heart by counting the number of successive pacing pulses achieving capture. This information may then be used by the device to adjust the manner in which the ATP therapy is delivered.

摘要翻译： 公开了用于递送抗心动过速起搏（ATP）的方法和系统。 在ATP突发的传送期间，将可植入的心律管理装置编程为感测诱发反应并且通过对实现捕获的连续起搏脉冲的数量进行计数来确定ATP突发是否夹带心脏。 然后该装置可以使用该信息来调整ATP疗法的输送方式。

公开(公告)号：US07477942B2

公开(公告)日：2009-01-13

申请号：US10909740

申请日：2004-08-02

申请人： Yunlong Zhang

发明人： Yunlong Zhang

IPC分类号： A61N1/365

CPC分类号： A61N1/3962 ,  A61N1/3622

摘要： A method and apparatus for delivering therapy to treat ventricular tachyarrhythmias is described. A ventricular tachyarrhythmia can be classified into tachycardia or fibrillation zones using a rate criterion so that the tachyarrhythmia can be treated with either anti-tachycardia pacing or shock therapy, respectively. Rate stability and morphology criteria are employed to determine if a tachyarrhythmia in the fibrillation zone is actually monomorphic ventricular tachycardia which can be treated with ATP.

摘要翻译： 描述了用于递送治疗以治疗室性快速性心律失常的方法和装置。 室性快速性心律失常可以使用速率标准分类为心动过速或颤动区，以便分别用抗心动过速起搏或休克疗法治疗快速性心律失常。 速率稳定性和形态学标准被用于确定原纤维化区域中的快速性心律失常是否实际上是可以用ATP治疗的单态性室性心动过速。

公开(公告)号：US20080288030A1

公开(公告)日：2008-11-20

申请号：US11748171

申请日：2007-05-14

申请人： Yunlong Zhang ,  James G. Bentsen ,  Yousufali Dalal

发明人： Yunlong Zhang ,  James G. Bentsen ,  Yousufali Dalal

IPC分类号： A61N1/18

CPC分类号： A61N1/36114 ,  A61B5/4035 ,  A61B5/4869 ,  A61B7/003 ,  A61B7/04 ,  A61M25/10 ,  A61M25/1002 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36571

摘要： A system delivers stimulation to volume receptors in the cardiovascular system to induce diuresis in a patient suffering volume overload. The system senses a volume signal indicative of a level of fluid retention in the patient's body and controls the delivery of the stimulation using the volume signal. In various embodiments, the stimulation includes one or more of electrical stimulation, which delivers electrical pulses to the volume receptors, and mechanical stimulation, which physically stretches the volume receptors.

摘要翻译： 系统向心血管系统中的体积受体提供刺激，以在患有体积过载的患者中诱发利尿。 该系统感测指示患者体内的液体保留水平的体积信号，并使用体积信号控制刺激的传送。 在各种实施例中，刺激包括将电脉冲传送到体积受体的电刺激和物理地拉伸体积受体的机械刺激中的一种或多种。

公开(公告)号：US20080058877A1

公开(公告)日：2008-03-06

申请号：US11469110

申请日：2006-08-31

申请人： Yunlong Zhang ,  Mark Schwartz

发明人： Yunlong Zhang ,  Mark Schwartz

IPC分类号： A61N1/39 ,  A61N1/00

CPC分类号： A61N1/3962 ,  A61N1/3601 ,  A61N1/36071

摘要： Systems and methods include sensing whether a shock to a heart is needed, and prior to delivering the shock, causing at least a partial contraction of a musculature in a chest, and delivering the shock while the musculature is at least partially contracted.

摘要翻译： 系统和方法包括检测是否需要对心脏的休克，以及在传递休克之前，引起胸部肌肉组织的至少部分收缩，以及在肌肉组织至少部分收缩期间递送休克。

公开(公告)号：US20060025822A1

公开(公告)日：2006-02-02

申请号：US10909740

申请日：2004-08-02

申请人： Yunlong Zhang

发明人： Yunlong Zhang

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3622

摘要： A method and apparatus for delivering therapy to treat ventricular tachyarrhythmias is described. A ventricular tachyarrhythmia can be classified into tachycardia or fibrillation zones using a rate criterion so that the tachyarrhythmia can be treated with either anti-tachycardia pacing or shock therapy, respectively. Rate stability and morphology criteria are employed to determine if a tachyarrhythmia in the fibrillation zone is actually monomorphic ventricular tachycardia which can be treated with ATP.

公开(公告)号：US08851828B2

公开(公告)日：2014-10-07

申请号：US13120169

申请日：2009-09-22

申请人： Yunlong Zhang

发明人： Yunlong Zhang

IPC分类号： F03D7/02 ,  F03D1/06

CPC分类号： F03D1/0608 ,  F05B2240/301 ,  F05B2250/232 ,  F05B2250/25 ,  Y02E10/721

摘要： The present invention discloses a rotor of wind energy conversion system (WECS) with the Venturi-tube effect. All the blades mounted on the blade-mounting seat envelop together to form a revolving-body cage turbine, which can be divided from structure into a head portion at the windward end, a tail portion at the wind exhaust end, and an airstream compression portion between the head portion and the tail portion and constituted by the enveloping blades. The revolution diameter of the airstream compression portion is gradually substantially increased from the head portion to the tail portion. The cage turbine forms a dynamic Venturi tube during the revolving process, with which the blade revolves to constitute its outline tube wall with the air permeability. The airstream passes through a window between the blades, and the incoming wind does work towards the blade during the process of permeating from the external space to the internal space of this outline tube wall, thus realizing the energy transfer.

摘要翻译： 本发明公开了具有文丘里管效应的风能转换系统（WECS）的转子。 安装在叶片安装座上的所有叶片一起包围以形成旋转体笼式涡轮机，其可以从结构分为迎风端的头部，风排气端的尾部和气流压缩部 在头部和尾部之间并由包封叶片构成。 气流压缩部的旋转直径从头部向尾部逐渐增大。 笼式涡轮机在旋转过程中形成动态文丘里管，叶片旋转以构成其具有透气性的轮廓管壁。 气流通过叶片之间的窗口，并且在从外部空间渗透到该外形管壁的内部空间的过程中，进入的风对叶片起作用，从而实现能量传递。