公开(公告)号：US20060116727A1

公开(公告)日：2006-06-01

申请号：US11276007

申请日：2006-02-09

申请人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Andrew Kramer

发明人： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Andrew Kramer

IPC分类号： A61N1/36

CPC分类号： A61N1/36592 ,  A61B5/0472 ,  A61N1/3627 ,  A61N1/3684

摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.

摘要翻译： 用于选择一个或多个心室以刺激心室再同步治疗的方法和装置。 包括QRS复合物在内的心内电图从左心室和右心室记录。 然后确定从左心室和右心室记录的内在心内电描记图之间的时间关系。 在一个实施例中，使用左心室和右心室感测的内心室去极化之间的延迟和一个或多个QRS复合物的持续时间间隔来确定时间关系。 在一个实施方案中，QRS复合物的持续时间由心脏内电刺激图或从表面心电图记录确定。 然后基于从右心室和左心室记录的内在心内电描记图与一个或多个QRS复合物的持续时间之间的时间关系来选择其中提供起搏脉冲的一个或多个心室。

公开(公告)号：US20060106429A1

公开(公告)日：2006-05-18

申请号：US10992319

申请日：2004-11-18

申请人： Imad Libbus ,  Andrew Kramer ,  Julia Moffitt

发明人： Imad Libbus ,  Andrew Kramer ,  Julia Moffitt

IPC分类号： A61N1/18

CPC分类号： A61N1/36117 ,  A61N1/08 ,  A61N1/36171

摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.

公开(公告)号：US20050131472A1

公开(公告)日：2005-06-16

申请号：US11049181

申请日：2005-02-02

申请人： Jiang Ding ,  Yinghong Yu ,  Andrew Kramer ,  Julio Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Andrew Kramer ,  Julio Spinelli

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/365

CPC分类号： E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机 心室起搏脉搏。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US20050038477A1

公开(公告)日：2005-02-17

申请号：US10624458

申请日：2003-07-21

申请人： Andrew Kramer ,  Veerichetty Kadhiresan ,  Jiang Ding ,  Lawrence Baumann ,  Scott Vanderlinde

发明人： Andrew Kramer ,  Veerichetty Kadhiresan ,  Jiang Ding ,  Lawrence Baumann ,  Scott Vanderlinde

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3682

摘要： A method and system for setting the operating parameters of a cardiac rhythm management device in which a plurality of parameter optimization algorithms are available. A measured feature of an electrophysiological signal such as QRS width has been shown to be useful in selecting among certain parameter optimization algorithms.

摘要翻译： 一种用于设定多个参数优化算法可用的心律管理装置的操作参数的方法和系统。 电生理信号（如QRS宽度）的测量特征已被证明可用于某些参数优化算法中的选择。