公开(公告)号：US09289619B2

公开(公告)日：2016-03-22

申请号：US11894100

申请日：2007-08-20

申请人： Andrew Kramer ,  Jeff Stahmann

发明人： Andrew Kramer ,  Jeff Stahmann

IPC分类号： A61N1/39 ,  A61N1/362

CPC分类号： A61N1/3956 ,  A61N1/3622

摘要： The present invention relates to identifying and using groups of cardiac events associated with depolarization wavefronts to coordinate the delivery of pacing therapy to the heart. According to one aspect of the invention, cardiac events associated with a plurality of cardiac sites are detected. The cardiac sites may be located in a single heart chamber or in bilateral heart chambers. A group of detected cardiac events associated with a depolarization wavefront is identified. According to another aspect of the invention, a particular cardiac event of an identified group associated with a depolarization wavefront may be used to synchronize pacing therapy delivered to the heart. According to yet another aspect, premature ventricular contractions may be classified using the identified groups.

公开(公告)号：US20080046057A1

公开(公告)日：2008-02-21

申请号：US11894100

申请日：2007-08-20

申请人： Andrew Kramer ,  Jeff Stahmann

发明人： Andrew Kramer ,  Jeff Stahmann

IPC分类号： A61N1/368

CPC分类号： A61N1/3956 ,  A61N1/3622

摘要： The present invention relates to identifying and using groups of cardiac events associated with depolarization wavefronts to coordinate the delivery of pacing therapy to the heart. According to one aspect of the invention, cardiac events associated with a plurality of cardiac sites are detected. The cardiac sites may be located in a single heart chamber or in bilateral heart chambers. A group of detected cardiac events associated with a depolarization wavefront is identified. According to another aspect of the invention, a particular cardiac event of an identified group associated with a depolarization wavefront may be used to synchronize pacing therapy delivered to the heart. According to yet another aspect, premature ventricular contractions may be classified using the identified groups.

摘要翻译： 本发明涉及识别和使用与去极化波前相关联的心脏事件组，以协调心脏起搏治疗的递送。 根据本发明的一个方面，检测与多个心脏部位相关联的心脏事件。 心脏部位可以位于单个心室或双侧心室中。 识别与去极化波前相关联的一组检测到的心脏事件。 根据本发明的另一方面，与去极化波前相关联的识别组的特定心脏事件可用于同步递送至心脏的起搏治疗。 根据另一方面，可以使用所识别的组来分类早产性心室收缩。

公开(公告)号：US20060271108A1

公开(公告)日：2006-11-30

申请号：US11135883

申请日：2005-05-24

申请人： Imad Libbus ,  Andrew Kramer ,  William Linder ,  Jeffrey Stahmann

发明人： Imad Libbus ,  Andrew Kramer ,  William Linder ,  Jeffrey Stahmann

IPC分类号： A61N1/36

CPC分类号： A61N1/36142 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/37

摘要： A neural stimulation system includes a safety control system that prevents delivery of neural stimulation pulses from causing potentially harmful effects. The neural stimulation pulses are delivered to one or more nerves to control the physiological functions regulated by the one or more nerves. Examples of such harmful effects include unintended effects in physiological functions associated with autonomic neural stimulation and nerve injuries caused by excessive delivery of the neural stimulation pulses.

公开(公告)号：US20060253161A1

公开(公告)日：2006-11-09

申请号：US11124791

申请日：2005-05-09

申请人： Imad Libbus ,  Andrew Kramer ,  Julio Spinelli

发明人： Imad Libbus ,  Andrew Kramer ,  Julio Spinelli

IPC分类号： A61N1/365

CPC分类号： A61N1/36057 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36585

摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.

公开(公告)号：US20060241704A1

公开(公告)日：2006-10-26

申请号：US11113828

申请日：2005-04-25

申请人： Allan Shuros ,  Tamara Baynham ,  Jihong Qu ,  Joseph Pastore ,  Andrew Kramer ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

发明人： Allan Shuros ,  Tamara Baynham ,  Jihong Qu ,  Joseph Pastore ,  Andrew Kramer ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

IPC分类号： A61N1/362

CPC分类号： A61N1/362 ,  A61B17/22 ,  A61B18/1492 ,  A61B2017/22001 ,  A61B2018/00214 ,  A61B2018/0041 ,  A61B2018/00422 ,  A61N1/056 ,  A61N1/3625 ,  A61N5/1001 ,  A61N2001/0585

摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.

公开(公告)号：US20060224202A1

公开(公告)日：2006-10-05

申请号：US11099226

申请日：2005-04-05

申请人： Julia Moffitt ,  Andrew Kramer ,  Imad Libbus

发明人： Julia Moffitt ,  Andrew Kramer ,  Imad Libbus

IPC分类号： A61N1/365

CPC分类号： A61N1/36114 ,  A61B5/0464 ,  A61N1/0587 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3962 ,  A61N2001/0585

摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.

公开(公告)号：US20060217772A1

公开(公告)日：2006-09-28

申请号：US11087935

申请日：2005-03-23

申请人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew Kramer ,  Ankur Garg ,  Kristofer James

发明人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew Kramer ,  Ankur Garg ,  Kristofer James

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/3621 ,  A61N1/3627

摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

公开(公告)号：US20060052830A1

公开(公告)日：2006-03-09

申请号：US11268284

申请日：2005-11-03

申请人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

发明人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

IPC分类号： A61N1/39

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

公开(公告)号：US20060004418A1

公开(公告)日：2006-01-05

申请号：US11218865

申请日：2005-09-02

申请人： Jeffrey Stahmann ,  Andrew Kramer ,  James Gilkerson ,  Lorenzo DiCarlo ,  Rene Wentkowski

发明人： Jeffrey Stahmann ,  Andrew Kramer ,  James Gilkerson ,  Lorenzo DiCarlo ,  Rene Wentkowski

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： A method and system for managing refractory periods in a cardiac rhythm management device configured for biventricular or biatrial sensing. Refractory periods for each channel of the pacemaker are provided by interval timers that are triggered by sensed or paced events in order to prevent misinterpretation of sensing signals.

公开(公告)号：US20050228454A1

公开(公告)日：2005-10-13

申请号：US11142165

申请日：2005-06-01

申请人： Andrew Kramer ,  Jeffrey Stahmann ,  Veerichetty Kadhiresan

发明人： Andrew Kramer ,  Jeffrey Stahmann ,  Veerichetty Kadhiresan

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3682 ,  A61N1/3684

摘要： A method of optimizing cardiac resynchronization therapy delay over a patient's full range of activity for use in operating an implantable cardiac pacing device and such a device are disclosed. The method includes measuring selected conduction time between selected sites in the heart for a plurality of beats and logging the values on a periodic repeating programmable basis to produce cumulative data and constructing a current template of conduction time in relation to one or more other sensed parameters of interest over a desired range of patient activity levels. The current template is used to derive suggested optimum pacing timing.