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71.发明授权Drug dispenser comprising a multiplicity of members acting together for successfully dispensing drug 失效药物分配器包括多个成员共同作用以成功分配药物
公开(公告)号：US4716031A
公开(公告)日：1987-12-29
申请号：US828810
申请日：1986-02-12
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译： 公开了一种用于将有益剂递送到使用环境的分配器。 分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。 墙壁上的通道将隔间与分配器的外部相连。
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公开(公告)号：US4455143A
公开(公告)日：1984-06-19
申请号：US360396
申请日：1982-03-22
申请人： Felix Theeuwes , Brian Barclay , Richard Cortese
发明人： Felix Theeuwes , Brian Barclay , Richard Cortese
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.
摘要翻译： 公开了用于将两种有益药物递送到使用环境的渗透装置。 该装置包括围绕分隔成包含药物的内腔的半透壁，所述第一隔室含有与含有不同药物的第二隔室分离的药物。 通过该壁的孔与第一隔室连通，用于从第一隔室输送药物，另一个穿过该壁的孔与第二隔室连通，用于从第二隔室输送药物。 在操作中，药物从每个隔室分开分配，流体通过壁被吸入每个隔室中，其速率由壁的渗透性和穿过壁的渗透压梯度相对于每个隔室中的药物控制，从而在每个隔室中产生 含有药物的溶液在长时间内以受控和连续的速率通过其孔口分配。
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公开(公告)号：US4449983A
公开(公告)日：1984-05-22
申请号：US360589
申请日：1982-03-22
申请人： Richard Cortese , Brian Barclay , Felix Theeuwes
发明人： Richard Cortese , Brian Barclay , Felix Theeuwes
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a wall surrounding a lumen divided into a first compartment containing a drug that is separated by a hydrogel partition from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug formulation from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug formulation from the second compartment. In operation, drug formulation is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug formulation in each compartment thereby producing in each compartment a solution containing drugs, and by the expansion and swelling of the hydrogel, whereby drug formulation is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.
摘要翻译： 公开了用于将两种有益药物递送到使用环境的渗透装置。 该装置包括围绕分隔成第一隔室的内壁的壁，所述第一隔室含有由水凝胶隔板与含有不同药物的第二隔室隔开的药物。 通过该壁的孔与第一隔室连通，用于从第一隔室输送药物制剂，并且穿过该壁的另一个孔与第二隔室连通，用于从第二隔室输送药物制剂。 在操作中，药物制剂与每个隔室分开分配，流体通过壁被吸入每个隔室，其速率由壁的渗透性和穿过壁的渗透压梯度相对于每个隔室中的药物制剂控制，从而在每个隔室中产生 隔室含有药物的溶液，以及水凝胶的膨胀和溶胀，由此药物制剂在长时间内以受控和连续的速率通过它们的孔分配。
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公开(公告)号：US20130028953A1
公开(公告)日：2013-01-31
申请号：US13486711
申请日：2012-06-01
申请人： Su II Yum , Felix Theeuwes
发明人： Su II Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61P29/00 , A61K31/4535
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译： 提供了通过皮肤施用舒芬太尼的透皮递送系统。 当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。 该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂， 优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。 还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。
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公开(公告)号：US08246977B2
公开(公告)日：2012-08-21
申请号：US11665813
申请日：2005-10-21
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译： 提供了通过皮肤施用舒芬太尼的透皮递送系统。 当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。 该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂， 优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。 还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。
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公开(公告)号：US20100016267A1
公开(公告)日：2010-01-21
申请号：US10592886
申请日：2005-03-15
申请人： Felix Theeuwes , Arthur J. Tipton
发明人： Felix Theeuwes , Arthur J. Tipton
CPC分类号： A61K9/0043
摘要： Pharmaceutical compositions for delivering a drug to a sinus in a subject are provided. The compositions are formed by the combination of a carrier material and a drug and are specially adapted for delivery to a sinus. The compositions have no fixed shape, and the carrier material serves to increase the viscosity or specific volume of the composition after introduction of the composition into the sinus. Also provided are methods for delivering a drug to a subject. The methods entail administering a pharmaceutical composition according to the present invention directly to a sinus. The drug is then released from the composition to the sinus. The pharmaceutical compositions can be administered to a sinus in liquid form, for example, as a suspension or solution using standard techniques. Also provided is the use of a carrier material in the manufacture of a drug delivery composition. The drug delivery composition is for delivering a drug to a sinus in a subject. The composition comprises the carrier material combined with the drug to be delivered, and has no fixed shape. After the composition is introduced into a sinus, the carrier material serves to increase the viscosity or specific volume of the composition.
摘要翻译： 提供用于将药物递送至受试者的窦的药物组合物。 组合物通过载体材料和药物的组合形成，并且特别适于递送至窦。 组合物没有固定的形状，并且载体材料用于在将组合物引入窦内后增加组合物的粘度或比体积。 还提供了将药物递送到受试者的方法。 所述方法需要将根据本发明的药物组合物直接给予鼻窦。 然后将药物从组合物释放到窦。 药物组合物可以以液体形式施用于窦，例如使用标准技术作为悬浮液或溶液施用。 还提供了载体材料在制备药物递送组合物中的用途。 药物递送组合物用于将药物递送至受试者的窦。 该组合物包含与待输送药物结合的载体材料，并且不具有固定形状。 在将组合物引入窦中之后，载体材料用于增加组合物的粘度或比体积。
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公开(公告)号：US20080260811A1
公开(公告)日：2008-10-23
申请号：US11888661
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K31/4436 , A61K9/70 , A61P43/00
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译： 提供了通过皮肤施用舒芬太尼的透皮递送系统。 当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。 该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂， 优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。 还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。
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公开(公告)号：US20080175890A1
公开(公告)日：2008-07-24
申请号：US11888650
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K31/4535 , A61K9/70 , A61P31/00
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
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公开(公告)号：US20070167932A1
公开(公告)日：2007-07-19
申请号：US11726517
申请日：2007-03-21
申请人： Felix Theeuwes , Su Yum
发明人： Felix Theeuwes , Su Yum
IPC分类号： A61K9/22
CPC分类号： A61M25/00 , A61M25/0043 , A61M2025/0057 , A61M2025/105 , A61M2025/1086
摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body defining a lumen between its proximal and distal ends, and a diffuser element, a dilutor element, or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.
摘要翻译： 本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括装置，其包括在其近端和远端之间限定内腔的细长主体，以及扩散器元件，稀释元件或两者。 对试剂选择性渗透的扩散器元件可与细长体可操作地连接，使得试剂流过细长体并进入并通过扩散器元件以离开系统。 稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。 稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。
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公开(公告)号：US07212853B1
公开(公告)日：2007-05-01
申请号：US08952368
申请日：1996-06-07
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448
摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.
摘要翻译： 提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。 该装置施加脉冲电输送电流，其中电流脉冲具有高于皮肤转化为更高的电转运递送效率（E）状态的临界水平（I C）以上的幅度。 最优选地，施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。
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