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25 条记录 (耗时 0.019 秒)

    Simultaneous delivery of two drugs from unit delivery device
    1.
    发明授权
    Simultaneous delivery of two drugs from unit delivery device 失效
    从单位传送装置同时递送两种药物

    公开(公告)号：US4449983A

    公开(公告)日：1984-05-22

    申请号：US360589

    申请日：1982-03-22

    申请人： Richard Cortese ,  Brian Barclay ,  Felix Theeuwes

    发明人： Richard Cortese ,  Brian Barclay ,  Felix Theeuwes

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M31/00

    CPC分类号： A61K9/0004

    摘要： An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a wall surrounding a lumen divided into a first compartment containing a drug that is separated by a hydrogel partition from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug formulation from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug formulation from the second compartment. In operation, drug formulation is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug formulation in each compartment thereby producing in each compartment a solution containing drugs, and by the expansion and swelling of the hydrogel, whereby drug formulation is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.

    摘要翻译： 公开了用于将两种有益药物递送到使用环境的渗透装置。 该装置包括围绕分隔成第一隔室的内壁的壁，所述第一隔室含有由水凝胶隔板与含有不同药物的第二隔室隔开的药物。 通过该壁的孔与第一隔室连通，用于从第一隔室输送药物制剂，并且穿过该壁的另一个孔与第二隔室连通，用于从第二隔室输送药物制剂。 在操作中，药物制剂与每个隔室分开分配，流体通过壁被吸入每个隔室，其速率由壁的渗透性和穿过壁的渗透压梯度相对于每个隔室中的药物制剂控制，从而在每个隔室中产生 隔室含有药物的溶液，以及水凝胶的膨胀和溶胀，由此药物制剂在长时间内以受控和连续的速率通过它们的孔分配。

    Osmotic device for dispensing two different medications
    2.
    发明授权
    Osmotic device for dispensing two different medications 失效
    渗透装置用于分配两种不同的药物

    公开(公告)号：US4455143A

    公开(公告)日：1984-06-19

    申请号：US360396

    申请日：1982-03-22

    申请人： Felix Theeuwes ,  Brian Barclay ,  Richard Cortese

    发明人： Felix Theeuwes ,  Brian Barclay ,  Richard Cortese

    IPC分类号： A61M31/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52

    CPC分类号： A61K9/0004

    摘要： An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.

    摘要翻译： 公开了用于将两种有益药物递送到使用环境的渗透装置。 该装置包括围绕分隔成包含药物的内腔的半透壁，所述第一隔室含有与含有不同药物的第二隔室分离的药物。 通过该壁的孔与第一隔室连通，用于从第一隔室输送药物，另一个穿过该壁的孔与第二隔室连通，用于从第二隔室输送药物。 在操作中，药物从每个隔室分开分配，流体通过壁被吸入每个隔室中，其速率由壁的渗透性和穿过壁的渗透压梯度相对于每个隔室中的药物控制，从而在每个隔室中产生 含有药物的溶液在长时间内以受控和连续的速率通过其孔口分配。

    Dosage form for delivering acid sensitive beneficial agent
    7.
    发明授权
    Dosage form for delivering acid sensitive beneficial agent 失效
    用于递送酸敏感剂的剂型

    公开(公告)号：US4743248A

    公开(公告)日：1988-05-10

    申请号：US895551

    申请日：1986-08-11

    申请人： Marc L. Bartoo ,  Patrick S. L. Wong ,  Felix Theeuwes ,  Brian Barclay

    发明人： Marc L. Bartoo ,  Patrick S. L. Wong ,  Felix Theeuwes ,  Brian Barclay

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0004

    摘要： A dosage form is disclosed, which dosage form comprises an outside wall and an inside wall, which inside wall comprises means for changing its structural integrity in response to fluid having a pH greater than 5 that enters the dosage form, thereby changing the pH environment inside the dosage form and concomitantly causing the inside wall to change its structural integrity, thus causing the outside wall to collapse and be easily eliminated from a host.

    摘要翻译： 公开了剂型，其剂型包括外壁和内壁，其内壁包括响应于进入剂型的pH大于5的流体改变其结构完整性的装置，从而改变内部的pH环境 剂型并伴随地导致内壁改变其结构完整性，从而导致外壁塌陷并容易地从主体中消除。

    Cassette for use in a medication delivery flow sensor assembly and method of making the same
    10.
    发明授权
    Cassette for use in a medication delivery flow sensor assembly and method of making the same 有权
    用于药物输送流量传感器组件的盒子及其制造方法

    公开(公告)号：US07819838B2

    公开(公告)日：2010-10-26

    申请号：US12469459

    申请日：2009-05-20

    申请人： John S. Ziegler ,  James D. Morrow ,  Olivier F. Currat ,  Jeff D. Bransky ,  Brian Barclay ,  Marwan A. Fathallah ,  James D. Jacobson

    发明人： John S. Ziegler ,  James D. Morrow ,  Olivier F. Currat ,  Jeff D. Bransky ,  Brian Barclay ,  Marwan A. Fathallah ,  James D. Jacobson

    IPC分类号： A61M31/00

    CPC分类号： A61M5/16886 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2205/3351 ,  A61M2205/3355

    摘要： A disposable assembly for use with a sensor assembly comprises a body, a flow restricting element, and a fluid pressure membrane. The body has a lid portion and a base portion. The body defines a fluid flow passage that forms an inlet and an outlet. The flow restricting element is positioned in the fluid flow passage between the inlet and the outlet. The membrane is located between the lid and base portions along the fluid flow passage. A reinforcing structure, such as a ring or a rigid disk, is positioned between the fluid pressure membrane and the lid portion to provide increased resistance to pressure in the fluid flow passage. The ring or disk can be a separate component or formed on the membrane. The membrane thickness adjacent to sensor access openings in the lid portion can be increased for pressure resistance, too.

    摘要翻译： 与传感器组件一起使用的一次性组件包括主体，流动限制元件和流体压力膜。 主体具有盖部分和基部部分。 主体限定形成入口和出口的流体流动通道。 流量限制元件位于入口和出口之间的流体流动通道中。 膜沿着流体流动通道位于盖和基部之间。 诸如环或刚性盘的加强结构位于流体压力膜和盖部分之间，以提供增加的流体流动通道中的压力阻力。 环或盘可以是单独的部件或形成在膜上。 也可以增加与盖部分中的传感器进入口相邻的膜厚度以实现耐压性。