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    Roller for peristaltic pumps having a plurality of projections to minimize current draw
    74.
    发明授权
    Roller for peristaltic pumps having a plurality of projections to minimize current draw 有权
    用于蠕动泵的滚筒具有多个突起以最小化电流消耗

    公开(公告)号：US06506035B1

    公开(公告)日：2003-01-14

    申请号：US09812718

    申请日：2001-03-20

    申请人： Kent F. Beck ,  Scott D. Miles ,  James A. Malmstrom

    发明人： Kent F. Beck ,  Scott D. Miles ,  James A. Malmstrom

    IPC分类号： F04B4312

    CPC分类号： F04B43/1253

    摘要： An improved roller for peristaltic pumps includes a central portion and a plurality of projections extending radially outwardly from the central portion. The projections enable use of a roller having a larger diameter, while ensuring that the tube carrying the solution is effectively pinched off. The larger diameter roller provides a greater moment arm and decreases current draw. The small projections used to accomplish the seal also severely deforms a smaller amount of tubing and thus requires less current draw.

    摘要翻译： 用于蠕动泵的改进辊包括中心部分和从中心部分径向向外延伸的多个突起。 这些突起使得能够使用具有较大直径的辊，同时确保承载溶液的管被有效地夹紧。 较大直径的辊提供更大的力矩臂并减少电流消耗。 用于实现密封的小突起也严重地使较小量的管子变形，因此需要更少的电流消耗。

    Oscillation apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
    76.
    发明授权
    Oscillation apparatus and methods for multi-analyte homogeneous fluoro-immunoassays 失效
    用于多分析物均匀荧光免疫测定的振荡装置和方法

    公开(公告)号：US06242267B1

    公开(公告)日：2001-06-05

    申请号：US09142946

    申请日：1998-09-18

    申请人： James N. Herron ,  Douglas A. Christensen ,  Scott D. Miles

    发明人： James N. Herron ,  Douglas A. Christensen ,  Scott D. Miles

    IPC分类号： G01N33552

    CPC分类号： G01N33/54386 ,  G01N33/54373 ,  Y10S435/808 ,  Y10S436/807

    摘要： An apparatus and method for rapidly analyzing samples for analytes of interest by an homogeneous immunofluorescence assay. The apparatus includes a sample test cartridge having a high control sample section, a low control sample section, and at least one test sample section. Each of these sections contain at least one pre-loaded reagent housed in a well within the cartridge wherein the low control sample section contains a known low amount of an analyte of interest and the high control sample section contains a known high amount of an analyte of interest. The cartridge includes a biosensor comprising a planar waveguide having first and second parallel plane surfaces and an edge extending between them, the edge having a receiving region for receiving a light beam. Each of the high control sample section, the low control sample section, and the test sample control sections have a well which includes a waveguide surface, wherein the contents of each section contacts capture molecules immobilized on the waveguide surface. The capture molecules are configured to specifically bind a chosen analyte and fluoresce when interacting with light passing through the waveguide surface. The concentration of said analyte of interest in said sample fluid is determined by a comparison of intensities of fluorescence of between said capture molecule areas of said sample capture molecule well, said low control capture molecule well, and said high control capture molecule well.

    摘要翻译： 用于通过均匀免疫荧光测定快速分析感兴趣的分析物的样品的装置和方法。 该装置包括具有高控制样品部分，低对照样品部分和至少一个测试样品部分的样品测试盒。 这些部分中的每一个包含至少一个预先加载的试剂，其容纳在筒内的孔中，其中低对照样品部分含有已知的低量感兴趣的分析物，并且高对照样品部分含有已知的大量分析物 利益。 所述盒包括生物传感器，所述生物传感器包括具有第一和第二平行平面的平面波导和在它们之间延伸的边缘，所述边缘具有用于接收光束的接收区域。 高控制采样部分，低控制样品部分和测试样品控制部分中的每一个具有包括波导表面的阱，其中每个部分的内容物接触固定在波导表面上的捕获分子。 捕获分子被配置为特异性地结合所选择的分析物并且当与通过波导表面的光相互作用时发出荧光。 通过比较所述样品捕获分子阱的所述捕获分子区域，所述低对照捕获分子阱和所述高对照捕获分子阱之间的荧光强度来确定所述样品流体中所述目标分析物的浓度。

    Method and apparatus for zero-calibration of a raman spectroscopy system
    77.
    发明授权
    Method and apparatus for zero-calibration of a raman spectroscopy system 失效
    拉曼光谱系统零校准的方法和装置

    公开(公告)号：US5452084A

    公开(公告)日：1995-09-19

    申请号：US38177

    申请日：1993-03-29

    申请人： John Mitchell ,  Scott D. Miles ,  Donald E. Gregonis ,  Kent F. Beck

    发明人： John Mitchell ,  Scott D. Miles ,  Donald E. Gregonis ,  Kent F. Beck

    IPC分类号： G01J3/02 ,  G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/65 ,  G01N2201/127 ,  G01N2201/1283

    摘要： A Raman spectroscopy system and method for determining a zero-calibration level. A gas sample chamber is located within a resonant cavity. A light source is located to cause light to be incident on the gas sample, the light resonates in the resonant cavity. Typically, the light source and resonator cavity in conjunction form a laser source which propagates coherent, monochromatic laser light energy through the gas sample. This causes Raman scattering from the gases constituent in the gas sample. The amount of Raman scattered light is measured at detectors along with light due to dark noise inherent in the detectors and glow from the laser source, i.e., light at wavelengths other than the laser light wavelength produced by the laser source. The resonator cavity is obstructed, via a ball inserted into the path of the laser beam for example, to prevent resonance. If the light source and resonant cavity in conjunction form a laser, prevention of resonance causes cessation of lasing. Thus, substantially no Raman scattering occurs and detectors measure light due primarily to background noise. The origin of the measurement scale for the detectors may then be set at the measured intensity, i.e., a zero-calibration level for the detectors may be determined.

    摘要翻译： 用于确定零校准水平的拉曼光谱系统和方法。 气体样品室位于谐振腔内。 定位光源以使光入射到气体样品上，该光在谐振腔中共振。 通常，光源和谐振腔共同形成激光源，其通过气体样品传播相干的单色激光光能。 这导致来自气体样品中的气体成分的拉曼散射。 由于检测器固有的暗噪声和来自激光源的辉光，即激光源产生的激光波长以外的波长的光，在检测器处测量拉曼散射光的量。 通过例如插入激光束的路径中的球阻挡谐振腔，以防止共振。 如果光源和谐振腔结合形成激光，防止共振就会导致激光的停止。 因此，基本上不发生拉曼散射，并且检测器主要由背景噪声测量光。 然后可以将检测器的测量标尺的原点设置为测量的强度，即可以确定检测器的零校准水平。

    Gas analysis system having buffer gas inputs to protect associated optical elements
    78.
    发明授权
    Gas analysis system having buffer gas inputs to protect associated optical elements 失效
    具有缓冲气体输入的气体分析系统保护相关的光学元件

    公开(公告)号：US5153671A

    公开(公告)日：1992-10-06

    申请号：US522533

    申请日：1990-05-11

    申请人： Scott D. Miles

    发明人： Scott D. Miles

    IPC分类号： G01N21/15 ,  G01N21/39 ,  G01N21/65 ,  G01N21/85

    CPC分类号： G01N21/15 ,  G01N2021/151 ,  G01N2021/391 ,  G01N2021/651 ,  G01N2021/8578 ,  G01N21/65

    摘要： A gas analysis cell positioned within an optical resonant cavity in a gas analysis system is disclosed wherein the cell includes a flow of buffer gas which forms a "dam", thereby protecting the optical elements in the analysis system. The analysis cell includes an inlet for introducing a gas sample into the analysis chamber of the cell. Two buffer gas inlet ports, one on each end of the cell, are provided to introduce a flow of buffer gas which is directed past optical elements in the system adjacent the ends of the cell. Two output ports are located at the ends of the analysis chamber to remove the buffer gas and gas sample mixture. The flow of buffer gas acts to confine the gas sample within the analysis chamber and reduce adverse effects which occur when the gas sample comes in contact with the optical elements of the system. By providing a constant non-turbulent flow of gas adjacent the system optics, adverse changes in index of refraction are avoided, thus reducing beam steering and Schlieren effects which can occur when Brewster windows or other optics are used to constrain the gas sample within the analysis cell. The buffer gas flow in the analysis cell of the present invention eliminates the need for gas cell windows which have intrinsic losses. This in turn minimizes losses which cause lower circulating intracavity power and signal strength.

    摘要翻译： 公开了一种位于气体分析系统中的光学谐振腔内的气体分析单元，其中所述单元包括形成“大坝”的缓冲气体流，从而保护分析系统中的光学元件。 分析单元包括用于将气体样品引入电池的分析室的入口。 提供两个缓冲气体入口端口，每个单元的每一端一个，以引入缓冲气体流，该缓冲气体流经过靠近电池端部的系统中的光学元件。 两个输出端口位于分析室的端部，以去除缓冲气体和气体样品混合物。 缓冲气体的流动用于将气体样品限制在分析室内，并减少当气体样品与系统的光学元件接触时发生的不利影响。 通过在系统光学器件附近提供恒定的非湍流气体，避免了折射率的不利变化，因此当使用布鲁斯特窗口或其他光学器件来限制分析中的气体样品时，可以发生波束转向和Schlieren效应 细胞。 本发明的分析池中的缓冲气体流动消除了对具有固有损失的气室的需求。 这又减少了导致循环腔内功率和信号强度降低的损失。