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公开(公告)号：US06172200B2
公开(公告)日：2001-01-09
申请号：US08954668
申请日：1997-10-20
IPC分类号： C07K1628
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. The patched genes permit production of patched protein and production of antibodies that bind to patched proteins. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.
摘要翻译： 提供了无脊椎动物和脊椎动物修补基因，包括小鼠和人修补基因，以及用于分离相关基因的方法，其中基因可以是不同种类或在同一家族中。 修补的基因允许产生修补的蛋白质并产生结合修补的蛋白质的抗体。 具有调节修补基因表达的能力，允许阐明胚胎发育，与修补基因的信号转导相关的细胞调节，激动剂和信号转导的拮抗剂的鉴定，鉴定用于结合修补的配体，分离 的配体，以及测定修补基因的转录和表达水平。
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公开(公告)号：US06027882A
公开(公告)日：2000-02-22
申请号：US656055
申请日：1996-05-31
IPC分类号： C07K14/435 , C07K14/705 , C12N5/02 , C12N15/12 , C12P19/34 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/705 , C07K14/43563 , A01K2217/05
摘要： Methods for isolating patched genes, particularly mammalian patched genes, including mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Loss-of function of the patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. Therefore, methods for using the patched gene as a diagnostic for assessing a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene, are disclosed.
摘要翻译： 提供了分离修补基因，特别是哺乳动物修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补的功能丧失与人类癌症，特别是皮肤基底细胞癌的发生有关。 癌症可能是家族性的，作为风险的组成部分是遗传性遗传倾向，或可能是零星的。 因此，公开了使用修补基因作为诊断用于评估癌症的遗传易感性并鉴定在该基因中具有突变的特异性癌症的方法。
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公开(公告)号：US5911799A
公开(公告)日：1999-06-15
申请号：US779336
申请日：1997-01-06
CPC分类号： B25B13/56 , B25B15/008 , B25G1/005 , B25G1/08 , B25G1/10
摘要： A generally cylindrical shaped tool handle holds multiple sizes of tools. The handle includes one or more holding slots each positioned on one of multiple surface faces into which hexagonal tools are inserted and held. Each holding slot is of a size and dimension which corresponds to a hexagonal tool size. In the preferred embodiment of the handle three of the faces have a single holding slot with multiple receiving holes for holding hexagonal wrenches of multiple sizes. A lock is positioned over the short leg of the hexagonal wrench and the holding slot to hold the wrench in position during use. The width of the bottom of the lock is smaller than the width of the top of the lock in order to give the lock a natural spring-like property, thereby allowing it to clamp onto the handle and remain in its locked position. The lock may be positioned to hold a tool in any one of the holding slots. In the preferred embodiment the lock includes inner ridges which are received by positioning slots, within the handle, in order to keep the lock from rotating around the handle during use. Hexagonal shaped tools other than wrenches may also be used with the handle of the present invention such as screwdrivers and socket wrenches. A multiple tool holder is designed to slide over the handle of the present invention and hold multiple sizes of tools which may be used with the handle. The tool holder includes a mounting magnet for mounting the handle and holder to a magnetic surface.
摘要翻译： 一个大致圆柱形的工具手柄可以保持多种尺寸的工具。 手柄包括一个或多个保持槽，每个保持槽定位在多个表面中的一个上，六边形工具被插入并保持在该表面中。 每个保持槽具有对应于六边形工具尺寸的尺寸和尺寸。 在手柄的优选实施例中，三个面具有单个保持槽，其具有用于保持多个尺寸的六角扳手的多个接收孔。 锁定件位于六角扳手的短腿和保持槽上，以在使用过程中将扳手固定就位。 锁的底部的宽度小于锁的顶部的宽度，以使锁具有天然的弹簧状特性，从而允许其夹紧在手柄上并保持在其锁定位置。 锁可以被定位成将工具保持在任何一个保持槽中。 在优选实施例中，锁包括通过在手柄内定位槽而接收的内脊，以便在使用期间保持锁在手柄周围旋转。 扳手以外的六角形工具也可以与本发明的手柄一起使用，例如螺丝刀和套筒扳手。 多个工具架被设计成在本发明的手柄上滑动并且保持可与手柄一起使用的多种尺寸的工具。 工具架包括用于将把手和保持器安装到磁性表面的安装磁体。
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公开(公告)号：USD392696S
公开(公告)日：1998-03-24
申请号：US67211
申请日：1997-02-21
申请人： Ronald L. Johnson
设计人： Ronald L. Johnson
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公开(公告)号：US5592859A
公开(公告)日：1997-01-14
申请号：US282828
申请日：1994-07-29
CPC分类号： B25G1/08 , B25B13/56 , B25B15/008 , B25G1/10
摘要： A generally cylindrical shaped tool handle holds multiple sizes of tools. The preferred embodiment of the handle is hexagonal shaped and holds multiple sizes of hexagonal tools. The handle includes one or more holding slots each positioned on one of multiple surface faces into which hexagonal tools are inserted and held. Each holding slot is of a size and dimension which corresponds to a hexagonal tool size. In use, a hexagonal wrench is positioned in the appropriate holding slot with the short leg or mounting end of the hexagonal wrench resting in the holding slot and the long leg of the hexagonal wrench extending through a receiving hole formed through the bottom of the slot and the tool handle. The long leg having a proximal end for driving the screw or tool. A lock is then positioned over the short leg of the hexagonal wrench and the holding slot. The width of the bottom of the lock is smaller than the width of the top of the lock in order to give the lock a natural spring-like property, thereby allowing it to clamp onto the handle and remain in its locked position. The lock is positionable along the handle on any surface face. The lock may be positioned to hold a tool in any one of the holding slots. The movement of the lock is enhanced by pinching external ridges located on the top sides of the lock and thereby spreading its bottom allowing it to slide along the handle. Hexagonal shaped tools other than wrenches may also be used with the handle of the present invention such as screwdrivers and socket wrenches.
摘要翻译： 一个大致圆柱形的工具手柄可以保持多种尺寸的工具。 手柄的优选实施例是六边形形状并且保持多种尺寸的六角形工具。 手柄包括一个或多个保持槽，每个保持槽定位在多个表面中的一个上，六边形工具被插入并保持在该表面中。 每个保持槽具有对应于六边形工具尺寸的尺寸和尺寸。 在使用中，六角扳手定位在适当的保持槽中，六边形扳手的短腿或安装端搁置在保持槽中，六角扳手的长腿延伸通过穿过槽的底部形成的接收孔， 工具把手。 长腿具有用于驱动螺钉或工具的近端。 然后将锁定位于六角扳手的短腿和保持槽上。 锁的底部的宽度小于锁的顶部的宽度，以使锁具有天然的弹簧状特性，从而允许其夹紧在手柄上并保持在其锁定位置。 锁可沿任何表面上的手柄定位。 锁可以被定位成将工具保持在任何一个保持槽中。 锁的移动通过夹住位于锁的顶侧上的外部隆起并由此扩展其底部而允许其沿着手柄滑动来增强。 扳手以外的六角形工具也可以与本发明的手柄一起使用，例如螺丝刀和套筒扳手。
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公开(公告)号：US5228360A
公开(公告)日：1993-07-20
申请号：US736179
申请日：1991-07-26
申请人： Ronald L. Johnson
发明人： Ronald L. Johnson
IPC分类号： B60K26/02 , F16H61/42 , F16H61/439 , F16H61/46 , F16H61/47
CPC分类号： F16H61/439 , B60K26/02 , F16H61/42 , F16H61/47 , Y10T74/20061 , Y10T74/20528 , Y10T74/2063 , Y10T74/20726
摘要： A cruise control system (10) for use with a hydrostatic drive system having a traction pedal (12) includes a pivotal link (42) and stops (44 and 46) comprising a lost motion connection between the traction pedal and the traction control linkage (30). Selective retention of the pump control lever is accomplished by a pair of electromagnets (64) responsive to a switch (88) associated with the lost motion connection.
摘要翻译： 一种与具有牵引踏板（12）的液压驱动系统一起使用的巡航控制系统（10）包括枢转连杆（42）和止动件（44和46），其包括牵引踏板和牵引力控制联动装置 30）。 泵控制杆的选择性保持由响应于与运动连接相关联的开关（88）的一对电磁体（64）来实现。
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77.发明授权
公开(公告)号：US4767003A
公开(公告)日：1988-08-30
申请号：US51223
申请日：1987-05-07
CPC分类号： H05K9/0067
摘要： A protective container is disclosed which includes an integral pocket for holding identification material relating to the contents of the container. The pocket and an associated tab over the pocket opening position the identification material such that bar code graphs or magnetic media mounted thereon can be easily read and accessed without requiring that the container be opened or removed from a stack of containers. In the disclosed embodiment, static protective foam liners are used to support the contents as well as provide an electrical path for any charge accumulated on the contents. The container is formed of an optically transparent material which is also static protective in nature. A viewing means is provided in the container and internal support means so that the presence or absence of any contents can be rapidly determined without opening the container.
摘要翻译： 公开了一种保护容器，其包括用于保持与容器的内容物相关的识别材料的整体式口袋。 口袋和相对于口袋开口的相关突片定位识别材料，使得可以容易地读取和访问安装在其上的条形码图或磁性介质，而不需要容器从一堆容器中打开或移开。 在所公开的实施例中，使用静电保护泡沫衬垫来支撑内容物，以及为内容物上累积的任何电荷提供电路径。 容器由光学透明材料形成，其本质上也是静态保护的。 在容器和内部支撑装置中设置观察装置，使得可以在不打开容器的情况下快速确定是否存在任何内容物。
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公开(公告)号：US4529423A
公开(公告)日：1985-07-16
申请号：US642546
申请日：1984-08-20
申请人： Ronald L. Johnson
发明人： Ronald L. Johnson
CPC分类号： B29C47/76 , B01D45/18 , B29C47/0023
摘要： A phase separator or vapor trap is provided for use with a plastic extruder. The phase separator includes housing means which define a first chamber for separating hydrocarbon compounds from exhaust vapor, an internal conduit located within the first chamber, and a couple which joins extruder discharge conduit with the inlet of the internal conduit. The inlet means provides a larger cross-sectional area than the extruder vapor exhaust conduit. The first chamber includes a baffle which surrounds the internal conduit and further defines at least one flow opening. The aggregate cross-sectional area of the flow openings are substantially the same as the cross-sectional area of the discharge conduit. Diffusion means adjustably attached to the end of the internal conduit causes radial diffusion of the exhaust vapor within the first chamber. The housing also includes a removable collection receptacle to collect residue which condensates out of the exhaust vapor and camming catches to seal the collection receptacle with the rest of the housing. A single worker can simultaneously support the collection receptacle and form the seal between the collection receptacle and the rest of the housing.
摘要翻译： 提供了一种用于塑料挤出机的相分离器或蒸汽阱。 相分离器包括壳体装置，其限定用于从排气蒸气分离烃化合物的第一室，位于第一室内的内部管道，以及将挤出机排出管道与内部管道的入口连接的联接件。 入口装置提供比挤出机蒸气排放管道更大的横截面面积。 第一室包括围绕内部导管的挡板，并进一步限定至少一个流动开口。 流动开口的总截面积与排放管道的横截面面积基本相同。 可调节地附接到内部管道的端部的扩散装置引起排气蒸气在第一室内的径向扩散。 壳体还包括可移除的收集容器，用于收集从排气蒸气中冷凝的残余物和凸轮捕获物，以将收集容器与壳体的其余部分密封。 单个工人可以同时支撑收集容器并在收集容器和壳体的其余部分之间形成密封。
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公开(公告)号：US4464551A
公开(公告)日：1984-08-07
申请号：US378485
申请日：1982-05-14
申请人： Ronald L. Johnson
发明人： Ronald L. Johnson
CPC分类号： H01H35/2657
摘要： The electric circuit controlling device has a snap acting member disposed in a housing and is adapted for successive discrete snap action motions from a stable configuration toward two unstable configurations. A pair of means are operable generally for switching between two circuit controlling modes and an actuating means is operable generally in response to the successive discrete snap action movements of the snap acting member for selectively operating the pair of switch means between the circuit controlling modes. A force transmitting means has at least two different force applying portions selectively associated in operating relation with the snap acting member to cause the successive discrete snap action movements from the stable configuration toward the two unstable configurations at different force levels. The device is provided with an adjusting arrangement wherein the magnitude of at least one of the two different force levels can readily be changed. A method of operating the electric circuit controlling device and a method of applying a calibrating force against the snap acting member are also disclosed.
摘要翻译： 电路控制装置具有设置在壳体中的卡扣作用构件，并且适用于从稳定构型到两个不稳定构型的连续离散快动动作。 一对装置通常用于在两个电路控制模式之间切换，并且致动装置通常可以响应于快速作用构件的连续离散的快速动作运动而可操作，用于在电路控制模式之间选择性地操作该对开关装置。 力传递装置具有至少两个不同的施力部分，所述至少两个不同的施力部分选择性地与所述弹力作用部件的操作关系相关联，以使所述连续离散的快速动作从不稳定的构型向不同的力水平下的两个不稳定构型移动。 该装置设置有调节装置，其中两个不同的力水平中的至少一个的大小可以容易地改变。 还公开了一种操作电路控制装置的方法以及对冲击作用构件施加校准力的方法。
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80.发明申请公开(公告)号：US20160128287A1
公开(公告)日：2016-05-12
申请号：US13914454
申请日：2013-06-10
IPC分类号： A01G27/00
摘要： A composite mat for water distribution to one or more potted plants comprises a bottom layer, a top layer and a core layer positioned between the bottom layer and the top layer. After water is distributed to the mat, the water is distributed evenly across the entirety of the core layer. When one or more potted plants are placed on the mat, water is passed from the core layer to the one or more potted plants and the plants are watered.
摘要翻译： 用于水分配到一个或多个盆栽植物的复合垫包括位于底层和顶层之间的底层，顶层和芯层。 水被分配到垫子之后，水分布在整个核心层上。 当将一个或多个盆栽植物放置在垫上时，水从核心层通过一个或多个盆栽植物，并将植物浇水。
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