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公开(公告)号：US06921646B2
公开(公告)日：2005-07-26
申请号：US09754032
申请日：2001-01-03
IPC分类号： G01N33/566 , C07K14/435 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12R1/91 , G01N33/15 , G01N33/567
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.
摘要翻译： 提供了无脊椎动物和脊椎动物修补基因，包括小鼠和人修补基因，以及用于分离相关基因的方法，其中基因可以是不同种类或在同一家族中。 具有调节修补基因表达的能力，允许阐明胚胎发育，与修补基因的信号转导相关的细胞调节，激动剂和信号转导的拮抗剂的鉴定，鉴定用于结合修补的配体，分离 的配体，以及测定修补基因的转录和表达水平。
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公开(公告)号：US06551782B1
公开(公告)日：2003-04-22
申请号：US09724631
申请日：2000-11-28
IPC分类号： C12Q168
CPC分类号： C07K14/43563 , A01K2217/05 , A01K2227/40 , C07K14/705
摘要： Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因，特别是哺乳动物修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 癌症可能是家族性的，作为风险的组成部分是遗传性遗传倾向，或可能是零星的。 修补和刺猬基因可用于为这些人类癌症创建转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的15个生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
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公开(公告)号：US06172200B2
公开(公告)日：2001-01-09
申请号：US08954668
申请日：1997-10-20
IPC分类号： C07K1628
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. The patched genes permit production of patched protein and production of antibodies that bind to patched proteins. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.
摘要翻译： 提供了无脊椎动物和脊椎动物修补基因，包括小鼠和人修补基因，以及用于分离相关基因的方法，其中基因可以是不同种类或在同一家族中。 修补的基因允许产生修补的蛋白质并产生结合修补的蛋白质的抗体。 具有调节修补基因表达的能力，允许阐明胚胎发育，与修补基因的信号转导相关的细胞调节，激动剂和信号转导的拮抗剂的鉴定，鉴定用于结合修补的配体，分离 的配体，以及测定修补基因的转录和表达水平。
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公开(公告)号：US06027882A
公开(公告)日：2000-02-22
申请号：US656055
申请日：1996-05-31
IPC分类号： C07K14/435 , C07K14/705 , C12N5/02 , C12N15/12 , C12P19/34 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/705 , C07K14/43563 , A01K2217/05
摘要： Methods for isolating patched genes, particularly mammalian patched genes, including mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Loss-of function of the patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. Therefore, methods for using the patched gene as a diagnostic for assessing a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene, are disclosed.
摘要翻译： 提供了分离修补基因，特别是哺乳动物修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补的功能丧失与人类癌症，特别是皮肤基底细胞癌的发生有关。 癌症可能是家族性的，作为风险的组成部分是遗传性遗传倾向，或可能是零星的。 因此，公开了使用修补基因作为诊断用于评估癌症的遗传易感性并鉴定在该基因中具有突变的特异性癌症的方法。
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公开(公告)号：US08178298B2
公开(公告)日：2012-05-15
申请号：US12685274
申请日：2010-01-11
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 修补和刺猬基因可用于为这些人类癌症创建转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
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公开(公告)号：US07465552B2
公开(公告)日：2008-12-16
申请号：US10421446
申请日：2003-04-22
IPC分类号： G01N33/567 , C12N5/02 , C12Q1/68 , C12P21/06
CPC分类号： C07K14/43563 , A01K2217/05 , A01K2227/40 , C07K14/705
摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
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公开(公告)号：US06429354B1
公开(公告)日：2002-08-06
申请号：US08918658
申请日：1997-08-22
IPC分类号： A01K67027
CPC分类号： C07K14/43563 , A01K2217/05 , A01K2227/40 , C07K14/705
摘要： Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful: in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因，特别是哺乳动物修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 癌症可能是家族性的，作为风险的组成部分是遗传性遗传倾向，或可能是零星的。 修补和刺猬基因是有用的：为这些人类癌症创造转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的15个生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
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公开(公告)号：US06610507B2
公开(公告)日：2003-08-26
申请号：US08954701
申请日：1997-10-20
IPC分类号： C07K100
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched,isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.
摘要翻译： 提供了无脊椎动物和脊椎动物修补基因，包括小鼠和人修补基因，以及用于分离相关基因的方法，其中基因可以是不同种类或在同一家族中。 具有调节修补基因表达的能力，允许阐明胚胎发育，与修补基因的信号转导相关的细胞调节，激动剂和信号转导的拮抗剂的鉴定，鉴定用于结合修补的配体，分离 的配体，以及测定修补基因的转录和表达水平。
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公开(公告)号：US5837538A
公开(公告)日：1998-11-17
申请号：US540406
申请日：1995-10-06
IPC分类号： G01N33/566 , C07K14/435 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12R1/91 , G01N33/15 , C12N5/16 , C12N15/11
CPC分类号： C07K14/47 , C07K14/43563 , C07K14/705 , A01K2217/05
摘要： Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.
摘要翻译： 提供了无脊椎动物和脊椎动物修补基因，包括小鼠和人修补基因，以及用于分离相关基因的方法，其中基因可以是不同种类或在同一家族中。 具有调节修补基因表达的能力，允许阐明胚胎发育，与修补基因的信号转导相关的细胞调节，激动剂和信号转导的拮抗剂的鉴定，鉴定用于结合修补的配体，分离 的配体，以及测定修补基因的转录和表达水平。
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公开(公告)号：US20100221724A1
公开(公告)日：2010-09-02
申请号：US12685274
申请日：2010-01-11
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 修补和刺猬基因可用于为这些人类癌症创建转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
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