-
公开(公告)号：US08178298B2
公开(公告)日：2012-05-15
申请号：US12685274
申请日：2010-01-11
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 修补和刺猬基因可用于为这些人类癌症创建转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
-
公开(公告)号：US07465552B2
公开(公告)日：2008-12-16
申请号：US10421446
申请日：2003-04-22
IPC分类号： G01N33/567 , C12N5/02 , C12Q1/68 , C12P21/06
CPC分类号： C07K14/43563 , A01K2217/05 , A01K2227/40 , C07K14/705
摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
-
公开(公告)号：US06429354B1
公开(公告)日：2002-08-06
申请号：US08918658
申请日：1997-08-22
IPC分类号： A01K67027
CPC分类号： C07K14/43563 , A01K2217/05 , A01K2227/40 , C07K14/705
摘要： Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful: in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因，特别是哺乳动物修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 癌症可能是家族性的，作为风险的组成部分是遗传性遗传倾向，或可能是零星的。 修补和刺猬基因是有用的：为这些人类癌症创造转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的15个生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
-
公开(公告)号：US07659371B2
公开(公告)日：2010-02-09
申请号：US11894801
申请日：2007-08-20
IPC分类号： C07K14/705
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 修补和刺猬基因可用于为这些人类癌症创建转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
-
公开(公告)号：US20080300167A1
公开(公告)日：2008-12-04
申请号：US11894801
申请日：2007-08-20
IPC分类号： A61K38/00 , C07K7/00 , C12N15/11 , C12N15/00 , C12N5/06 , C12P21/04 , C07K16/18 , C12Q1/68 , C12Q1/02 , A61P43/00
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 修补和刺猬基因可用于为这些人类癌症创建转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
-
公开(公告)号：US06946257B1
公开(公告)日：2005-09-20
申请号：US08916140
申请日：1997-08-21
IPC分类号： C07K14/435 , C07K14/705 , G01N33/567 , C12N5/02
CPC分类号： C07K14/43563 , A01K2217/05 , A01K2227/40 , C07K14/705
摘要： Methods are provided for identifying agents that decrease hedgehog signal transduction for ameliorating an effect of loss of function of a patched gene in a mammalian cell.
摘要翻译： 提供了用于鉴定减少刺猬蛋白信号转导以改善哺乳动物细胞中修补基因功能丧失的作用的试剂的方法。
-
公开(公告)号：US06551782B1
公开(公告)日：2003-04-22
申请号：US09724631
申请日：2000-11-28
IPC分类号： C12Q168
CPC分类号： C07K14/43563 , A01K2217/05 , A01K2227/40 , C07K14/705
摘要： Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因，特别是哺乳动物修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 癌症可能是家族性的，作为风险的组成部分是遗传性遗传倾向，或可能是零星的。 修补和刺猬基因可用于为这些人类癌症创建转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的15个生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
-
公开(公告)号：US06027882A
公开(公告)日：2000-02-22
申请号：US656055
申请日：1996-05-31
IPC分类号： C07K14/435 , C07K14/705 , C12N5/02 , C12N15/12 , C12P19/34 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/705 , C07K14/43563 , A01K2217/05
摘要： Methods for isolating patched genes, particularly mammalian patched genes, including mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Loss-of function of the patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. Therefore, methods for using the patched gene as a diagnostic for assessing a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene, are disclosed.
摘要翻译： 提供了分离修补基因，特别是哺乳动物修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补的功能丧失与人类癌症，特别是皮肤基底细胞癌的发生有关。 癌症可能是家族性的，作为风险的组成部分是遗传性遗传倾向，或可能是零星的。 因此，公开了使用修补基因作为诊断用于评估癌症的遗传易感性并鉴定在该基因中具有突变的特异性癌症的方法。
-
公开(公告)号：US5759811A
公开(公告)日：1998-06-02
申请号：US748591
申请日：1996-11-13
申请人： Ervin Epstein , Zhilan Hu , Jeanette Bonifas
发明人： Ervin Epstein , Zhilan Hu , Jeanette Bonifas
CPC分类号： C07K14/4702 , A61K38/00
摘要： A mutation in the human sonic hedgehog gene is associated with tumorigenesis. A variety of human tumors, including basal cell carcinomas, breast carcinomas, medulloblastomas, etc., have a somatic mutation that results in an amino acid substitution at position 133 �*his133 SHH!, or in a mutation at position 114. Such mutated genes and fragments thereof, encoded protein, and antibodies specific for the mutated protein are useful in characterizing the phenotype of associated tumors. The mutant protein is useful in drug screening for compositions that antagonize or otherwise modulate HH activity or expression. The encoded protein is also used as a therapeutic, to modulate cell proliferation and differentiation, and treatment of pathological conditions associated with decreased hedgehog signaling.
摘要翻译： 人类声波刺猬蛋白基因突变与肿瘤发生相关。 各种人类肿瘤，包括基底细胞癌，乳腺癌，成神经管细胞瘤等都具有体细胞突变，导致在第133位[* his133 SHH]或114位突变中的氨基酸取代。这种突变基因 其片段，编码蛋白质和对突变蛋白质特异的抗体可用于表征相关肿瘤的表型。 突变蛋白可用于药物筛选拮抗或以其他方式调节HH活性或表达的组合物。 编码的蛋白质也用作治疗，调节细胞增殖和分化，以及治疗与减少刺猬蛋白信号传导相关的病理状况。
-
公开(公告)号：US20100221724A1
公开(公告)日：2010-09-02
申请号：US12685274
申请日：2010-01-11
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/43563 , C07K14/705
摘要： Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.
摘要翻译： 提供了分离修补基因（包括小鼠和人修补基因）以及无脊椎动物修补基因和序列的方法。 修补后的表达减少与人类癌症，特别是皮肤基底细胞癌的发生有关。 修补和刺猬基因可用于为这些人类癌症创建转基因动物模型。 修补的核酸组合物用于鉴定同源或相关蛋白质和编码这种蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如癌症的治疗，基于表达的细胞类型的鉴别等。 该DNA进一步用于诊断癌症的遗传易感性，并鉴定具有该基因突变的特异性癌症。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.018 秒)
