公开(公告)号：US06642377B1

公开(公告)日：2003-11-04

申请号：US10030909

申请日：2002-01-14

申请人： Akio Kayano ,  Hiroyuki Chiba ,  Taiju Nakamura ,  Shin Sakurai ,  Hiroyuki Ishizuka ,  Hiroyuki Saito ,  Yuuki Komatsu ,  Manabu Sasho ,  Nobuaki Sato ,  Shigeto Negi

发明人： Akio Kayano ,  Hiroyuki Chiba ,  Taiju Nakamura ,  Shin Sakurai ,  Hiroyuki Ishizuka ,  Hiroyuki Saito ,  Yuuki Komatsu ,  Manabu Sasho ,  Nobuaki Sato ,  Shigeto Negi

IPC分类号： C07D47720

CPC分类号： C07D477/20 ,  C07D477/02 ,  C07D477/08 ,  Y02P20/55

摘要： A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: wherein the ring A means the basic antibiotic; R10 means a protected functional group used in organic synthesis; Ak—E means the alkali earth metal; and B means the inorganic acid, respectively.

摘要翻译： 一种制备方法，其包括使碱性抗生素 - 草酸盐（II）与无机酸的碱土金属盐（III）进行盐交换：其中环A表示碱性抗生素; R 10表示有机合成中使用的被保护的官能团; Ak-E表示碱土金属; B分别表示无机酸。

公开(公告)号：US5826049A

公开(公告)日：1998-10-20

申请号：US916630

申请日：1992-07-22

申请人： Yasuhiro Ogata ,  Junji Nakagoshi ,  Naoki Hamanaka ,  Hiroyuki Chiba ,  Shinichi Shutoh ,  Tatsuo Higuchi ,  Shigeo Takeuchi ,  Taturu Toba ,  Teruo Tanaka

发明人： Yasuhiro Ogata ,  Junji Nakagoshi ,  Naoki Hamanaka ,  Hiroyuki Chiba ,  Shinichi Shutoh ,  Tatsuo Higuchi ,  Shigeo Takeuchi ,  Taturu Toba ,  Teruo Tanaka

IPC分类号： G06F15/173 ,  G06F15/80 ,  G06F15/163

CPC分类号： G06F15/17368

摘要： In order to determine a transfer path of a message to a receiving-end processor group, a processor includes a routing bit generation circuit, and an exchange switch includes partial broadcast path control circuits and a path control information alteration circuit. In order to define the range of a receiving-end processor group, a network includes transfer control circuits. A crossbar switch includes transfer control circuits associated with output ports and a boundary register group. When a partial broadcast message is transferred from an input port in the downstream direction of an output port, it is decided whether a belonging to the partial broadcast range associated with a connected to the particular input port is connected to the particular output port, whereby the particular partial broadcast message is transferred from the same output port.

摘要翻译： 为了确定消息到接收端处理器组的传送路径，处理器包括路由位生成电路，并且交换交换机包括部分广播路径控制电路和路径控制信息改变电路。 为了定义接收端处理器组的范围，网络包括传送控制电路。 交叉开关包括与输出端口和边界寄存器组相关联的传输控制电路。 当在输出端口的下游方向上从输入端口传送部分广播消息时，确定属于与连接到特定输入端口的连接的部分广播范围是否连接到特定输出端口，由此 特定的部分广播消息从相同的输出端口传送。

公开(公告)号：US4933439A

公开(公告)日：1990-06-12

申请号：US272601

申请日：1988-11-17

申请人： Takeo Yoshioka ,  Azuma Watanabe ,  Hiroyuki Chiba ,  Kaichiro Kominato ,  Kohki Kiyoshima ,  Yasuo Fukagawa ,  Hiroshi Tone ,  Rokuro Okamoto

发明人： Takeo Yoshioka ,  Azuma Watanabe ,  Hiroyuki Chiba ,  Kaichiro Kominato ,  Kohki Kiyoshima ,  Yasuo Fukagawa ,  Hiroshi Tone ,  Rokuro Okamoto

IPC分类号： C07H17/08

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： Tylosin derivatives represented by the following general formula (I): ##STR1## [wherein R denotes a hydrogen atom, acetyl, propionyl or a radical of Si(R.sup.2).sub.3 (in which R.sup.2 is a lower alkyl group), and R.sup.1 stands for a hydrogen atom or a radical of Si(R.sup.2 .sub.3 ] are useful as intermediates for the synthesis of 4"-acyl derivatives of tylosin because, after introduction of any desired acyl group at the 4"-hydroxyl group, the silyl protective group can be readily removed without liberation of the acyl group. This invention also provides processes for producing the tylosin derivatives. More specifically, it provides a melthod of selectively protecting 2'- and 4"'-hydroxyl groups of tylosin (those of higher reactivity among the hydroxyl groups involved); a method of selectively protecting only the 4"'-hydroxyl group of tylosin; a method of selectively protecting the 3- and 4"'-hydroxyl groups of 2'-O-acyltylosin; and a method of protecting 3-, 2'- and 4"'-hydroxyl groups of tylosin.