公开(公告)号：US07628802B2

公开(公告)日：2009-12-08

申请号：US11333485

申请日：2006-01-17

申请人： Jason White ,  David Stern

发明人： Jason White ,  David Stern

IPC分类号： A61F2/06

CPC分类号： A61F2/844 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/91591 ,  A61F2220/0091 ,  Y10T403/32418

摘要： A stent is constructed using interconnected links having micro-mechanical latching mechanisms. The micro-mechanical latching elements allow relative rotational movement of interconnected links in one rotational direction but restrict relative rotational movement of the two links in the opposite direction. The micro-mechanical latch surface features are formed using micro-electronic mechanical systems (MEMS) manufacturing methods. The male surface of the latching components contains an array of ridges or protrusions, and the receiving surface contains a matching array of recesses. The array of ridges or protrusions and the corresponding recesses have uniformly dissimilar slopes that result in a substantially greater frictional force in one direction than in the opposite direction. The separation distance between the two surfaces is such that the male latch surface is engaged with the receiving surface recesses in the low stress “locked” state, preventing motion in the undesired direction. Each male ridge or protrusion can be underlined by a void that promotes elastic deflection when sliding in the desired direction and recovery into the ‘locked ’ state when aligned with the recesses.

摘要翻译： 使用具有微机械闭锁机构的互连连接构造支架。 微机械闭锁元件允许互连连杆在一个旋转方向上的相对旋转运动，但限制两个连杆在相反方向上的相对旋转运动。 使用微电子机械系统（MEMS）制造方法形成微机械闩锁表面特征。 闩锁部件的阳表面包含脊或突起的阵列，并且接收表面包含匹配的凹槽阵列。 脊或突起的阵列和相应的凹槽具有均匀不相似的斜面，其在一个方向上产生比在相反方向上显着更大的摩擦力。 两个表面之间的分隔距离使得阳锁闩表面在低应力“锁定”状态下与接收表面凹部接合，从而防止在不期望的方向上的运动。 每个阳脊或突起可以由空隙加下划线，当空穴在所需方向上滑动时，该空隙促进弹性挠曲，并且当与凹槽对准时恢复到“锁定”状态。

公开(公告)号：US07618363B2

公开(公告)日：2009-11-17

申请号：US10636293

申请日：2003-08-06

申请人： Jay Yadav ,  Mark Allen ,  David O'Brien ,  David Stern ,  Jason White ,  Michael A. Fonseca

发明人： Jay Yadav ,  Mark Allen ,  David O'Brien ,  David Stern ,  Jason White ,  Michael A. Fonseca

IPC分类号： A61M1/12

CPC分类号： A61M1/106 ,  A61M1/1008 ,  A61M1/1068 ,  A61M1/12

摘要： A ventricular assist device comprises a sheet of hydraulically actuated material that can be affixed to prescribed locations on the surface of the heart to assist areas of the heart that do not contract normally. The material is comprised of a network of contractible unit cells that individually contract when fluid is pumped into them. These unit cells are connected together in a network that causes the sheet to contract radially inward. This contraction causes the sheet to transmit forces to the heart to assist in its natural contraction. A sensing function coordinates the contraction of the sheet with the contraction of the heart. The change in shape of the device is accomplished by distributing pressurized fluid throughout the spaces of the device by way of a network of channels. When pressure is removed from the fluid system, it assumes a deenergized “rest” position in which it does not transmit any forces to the surface of the heart. This property of the device prevents the device from inhibiting the heart's natural contractions in the event of a failure of the device or a loss of hydraulic power.

摘要翻译： 心室辅助装置包括一片液压致动材料片，该片材可以固定在心脏表面上的规定位置，以帮助心脏不能正常收缩的区域。 该材料由可收缩的单体电池网络组成，当将流体泵入其中时单独收缩。 这些单电池在网络中连接在一起，导致片材向内径向收缩。 这种收缩导致片材将力传递到心脏以帮助其自然收缩。 检测功能可以协调纸张与心脏收缩的收缩。 设备形状的变化通过通过通道网络将加压流体分配到设备的整个空间中来实现。 当压力从流体系统移除时，它承受断电的“静止”位置，在该位置，它不会将任何力传递到心脏表面。 该装置的这种特性防止装置在装置发生故障或液压动力损失的情况下抑制心脏的自然收缩。

公开(公告)号：US07494972B2

公开(公告)日：2009-02-24

申请号：US11319949

申请日：2005-12-27

申请人： David Stern ,  Ann Marie Schmidt

发明人： David Stern ,  Ann Marie Schmidt

IPC分类号： A61K38/00 ,  C07K14/00

CPC分类号： A61K38/1774 ,  Y10S514/824 ,  Y10S514/866 ,  Y10S514/909

摘要： The present invention provides for a method to prevent accelerated atherosclerosis in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent accelerated atherosclerosis in the subject. The present invention also provides for a method to prevent a macrovessel disease in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent macrovessel disease in the subject.

摘要翻译： 本发明提供了预防易感患者的加速动脉粥样硬化的方法，其包括以有效预防受试者加速的动脉粥样硬化的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。 本发明还提供一种预防患者易患有大血管疾病的方法，其包括以有效预防受试者的宏观血管疾病的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。

公开(公告)号：US20090030291A1

公开(公告)日：2009-01-29

申请号：US12175803

申请日：2008-07-18

申请人： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

发明人： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

IPC分类号： A61B5/00

CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/076 ,  Y10T29/49016 ,  Y10T29/49069 ,  Y10T29/49071 ,  Y10T29/49073

摘要： A wireless sensor for indicating a physical state within an environment includes a unitary housing defining a cavity. A structure located within the cavity of the housing has elements providing capacitance, the elements being arranged such that the distance and thereby the capacitance of the structure changes when a physical state of the environment changes. The structure has a resonant frequency based at least in part on the capacitance of the structure when in the presence of a fluctuating electromagnetic field. When the sensor is positioned within an environment and is subjected to a fluctuating electromagnetic field, the resonant frequency indicates the physical state of the environment.

摘要翻译： 用于指示环境中的物理状态的无线传感器包括限定空腔的整体壳体。 位于壳体的腔内的结构具有提供电容的元件，该元件被布置成使得当环境的物理状态改变时，结构的距离以及由此的结构的电容改变。 当存在波动的电磁场时，该结构至少部分地基于结构的电容。 当传感器位于环境中并且经受波动的电磁场时，谐振频率表示环境的物理状态。

公开(公告)号：USD583041S1

公开(公告)日：2008-12-16

申请号：US29271099

申请日：2007-01-11

申请人： David Stern ,  Kenneth H. Stern ,  Fred Bishop ,  Jules Stern ,  John Hofsess

设计人： David Stern ,  Kenneth H. Stern ,  Fred Bishop ,  Jules Stern ,  John Hofsess

公开(公告)号：US20070099829A1

公开(公告)日：2007-05-03

申请号：US11319949

申请日：2005-12-27

申请人： David Stern ,  Ann Schmidt

发明人： David Stern ,  Ann Schmidt

IPC分类号： A61K38/17

CPC分类号： A61K38/1774 ,  Y10S514/824 ,  Y10S514/866 ,  Y10S514/909

摘要： The present invention provides for a method to prevent accelerated atherosclerosis in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent accelerated atherosclerosis in the subject. The present invention also provides for a method to prevent a macrovessel disease in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent macrovessel disease in the subject.

摘要翻译： 本发明提供了预防易感患者的加速动脉粥样硬化的方法，其包括以有效预防受试者加速的动脉粥样硬化的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。 本发明还提供一种预防患者易患有大血管疾病的方法，其包括以有效预防受试者的宏观血管疾病的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。

公开(公告)号：US20060287602A1

公开(公告)日：2006-12-21

申请号：US11157375

申请日：2005-06-21

申请人： David O'Brien ,  Jason White ,  Michael Fonseca ,  Florent Cros ,  Jason Kroh ,  David Stern ,  Mark Allen

发明人： David O'Brien ,  Jason White ,  Michael Fonseca ,  Florent Cros ,  Jason Kroh ,  David Stern ,  Mark Allen

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/0031 ,  A61B5/0215 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2562/028

摘要： A sensor suitable for in vivo implantation has a capacitive circuit and a three-dimensional inductor coil connected to the capacitive circuit to form an LC circuit. The LC circuit is hermetically encapsulated within an electrically insulating housing. An electrical characteristic of the LC circuit is responsive to a change in an environmental parameter.

摘要翻译： 适用于体内植入的传感器具有电容电路和连接到电容电路的三维电感线圈，以形成LC电路。 LC电路气密地封装在电绝缘壳体内。 LC电路的电气特性响应于环境参数的变化。

公开(公告)号：US07147604B1

公开(公告)日：2006-12-12

申请号：US10215379

申请日：2002-08-07

申请人： Mark Allen ,  Michael Fonseca ,  Jason White ,  Jason Kroh ,  David Stern

发明人： Mark Allen ,  Michael Fonseca ,  Jason White ,  Jason Kroh ,  David Stern

IPC分类号： A61B5/00

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B2562/028

摘要： A sensor for wirelessly determining a physical property within a defined space comprises an electrical resonance and has a high quality factor Q. The quality factor Q is sufficiently high that a signal generated by the sensor can be received outside the defined space. The sensor may optimally have a dielectric coating.

摘要翻译： 用于在确定的空间内无线地确定物理性质的传感器包括电谐振并且具有高质量因子Q.品质因数Q足够高，使得由传感器产生的信号可被接收在限定的空间之外。 传感器可以最佳地具有电介质涂层。

公开(公告)号：US20060253035A1

公开(公告)日：2006-11-09

申请号：US11379641

申请日：2006-04-21

申请人： David Stern

发明人： David Stern

IPC分类号： A61B6/00

CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456

摘要： An embodiment of a system for acquiring images of a probe array is described that comprises a first light emitting diode that provides light comprising a first range of wavelengths outside of an excitation spectrum; a second light emitting diode that provides light comprising a second range of wavelengths inside of the excitation spectrum; and a detector that detects one or more wavelengths in the first range of wavelengths, wherein the first range of wavelengths comprise light wavelengths emitted from fluorescent molecules associated with one or more probes of the probe array in response to the second range of wavelengths and wavelengths reflected from one or more reflective elements associated with the probe array.

摘要翻译： 描述了一种用于获取探针阵列的图像的系统的实施例，其包括提供包含激发光谱外的第一波长范围的光的第一发光二极管; 第二发光二极管，其提供包含激发光谱内的第二波长范围的光; 以及检测器，其检测所述第一波长范围中的一个或多个波长，其中所述第一波长范围包括响应于所述第二波长和波长范围反射的与所述探针阵列的一个或多个探针相关联的荧光分子发射的光波长 来自与探针阵列相关联的一个或多个反射元件。

公开(公告)号：US07125675B2

公开(公告)日：2006-10-24

申请号：US09851071

申请日：2001-05-08

申请人： Ann Marie Schmidt ,  David Stern

发明人： Ann Marie Schmidt ,  David Stern

IPC分类号： G01N33/53 ,  C12Q1/00 ,  C12N5/00

CPC分类号： C07K14/70503 ,  A61K38/00 ,  A61K48/00

摘要： The present invention provides for a method for inhibiting tumor invasion or metastasis in a subject which comprises administering to the subject a therapeutically effective amount of a form of soluble Receptor for Advanced Glycation Endproducts (RAGE). The present invention also provides a method for evaluating the ability of an agent to inhibit tumor invasion in a local cellular environment which comprises: (a) admixing with cell culture media an effective amount of the agent; (b) contacting a tumor cell in cell culture with the media from step (a); (c) determining the amount of spreading of the tumor cell culture, and (d) comparing the amount of spreading of the tumor cell culture determined in step (c) with the amount determined in the absence of the agent, thus evaluating the ability of the agent to inhibit tumor invasion in the local cellular environment. The present invention also provides a pharmaceutical composition which comprises a therapeutically effective amount of the agent evaluated in the aforementioned method and a pharmaceutically acceptable carrier.