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    Hydraulically actuated artificial muscle for ventricular assist
    1.
    发明授权
    Hydraulically actuated artificial muscle for ventricular assist 有权
    用于心室辅助的液压致动人造肌肉

    公开(公告)号：US07618363B2

    公开(公告)日：2009-11-17

    申请号：US10636293

    申请日：2003-08-06

    申请人： Jay Yadav ,  Mark Allen ,  David O'Brien ,  David Stern ,  Jason White ,  Michael A. Fonseca

    发明人： Jay Yadav ,  Mark Allen ,  David O'Brien ,  David Stern ,  Jason White ,  Michael A. Fonseca

    IPC分类号： A61M1/12

    CPC分类号： A61M1/106 ,  A61M1/1008 ,  A61M1/1068 ,  A61M1/12

    摘要： A ventricular assist device comprises a sheet of hydraulically actuated material that can be affixed to prescribed locations on the surface of the heart to assist areas of the heart that do not contract normally. The material is comprised of a network of contractible unit cells that individually contract when fluid is pumped into them. These unit cells are connected together in a network that causes the sheet to contract radially inward. This contraction causes the sheet to transmit forces to the heart to assist in its natural contraction. A sensing function coordinates the contraction of the sheet with the contraction of the heart. The change in shape of the device is accomplished by distributing pressurized fluid throughout the spaces of the device by way of a network of channels. When pressure is removed from the fluid system, it assumes a deenergized “rest” position in which it does not transmit any forces to the surface of the heart. This property of the device prevents the device from inhibiting the heart's natural contractions in the event of a failure of the device or a loss of hydraulic power.

    摘要翻译： 心室辅助装置包括一片液压致动材料片，该片材可以固定在心脏表面上的规定位置，以帮助心脏不能正常收缩的区域。 该材料由可收缩的单体电池网络组成，当将流体泵入其中时单独收缩。 这些单电池在网络中连接在一起，导致片材向内径向收缩。 这种收缩导致片材将力传递到心脏以帮助其自然收缩。 检测功能可以协调纸张与心脏收缩的收缩。 设备形状的变化通过通过通道网络将加压流体分配到设备的整个空间中来实现。 当压力从流体系统移除时，它承受断电的“静止”位置，在该位置，它不会将任何力传递到心脏表面。 该装置的这种特性防止装置在装置发生故障或液压动力损失的情况下抑制心脏的自然收缩。

    Implantable wireless sensor
    2.
    发明授权
    Implantable wireless sensor 有权
    可植入无线传感器

    公开(公告)号：US09265428B2

    公开(公告)日：2016-02-23

    申请号：US12175803

    申请日：2008-07-18

    申请人： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

    发明人： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

    IPC分类号： A61B5/02 ,  A61B5/00 ,  A61B5/07

    CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/076 ,  Y10T29/49016 ,  Y10T29/49069 ,  Y10T29/49071 ,  Y10T29/49073

    摘要： A wireless sensor for indicating a physical state within an environment includes a housing defining a hermetically sealed cavity. A structure located within the cavity of the housing has elements providing capacitance, the elements being arranged such that the distance and thereby the capacitance of the structure changes when a physical state of the environment changes. The structure has a resonant frequency based at least in part on the capacitance of the structure when in the presence of a fluctuating electromagnetic field. When the sensor is positioned within an environment and is subjected to a fluctuating electromagnetic field, the resonant frequency indicates the physical state of the environment.

    摘要翻译： 用于指示环境中的物理状态的无线传感器包括限定密封空腔的壳体。 位于壳体的腔内的结构具有提供电容的元件，该元件被布置成使得当环境的物理状态改变时，结构的距离以及由此的结构的电容改变。 当存在波动的电磁场时，该结构至少部分地基于结构的电容。 当传感器位于环境中并且经受波动的电磁场时，谐振频率表示环境的物理状态。

    Implantable Wireless Sensor
    3.
    发明申请
    Implantable Wireless Sensor 有权
    可植入式无线传感器

    公开(公告)号：US20090030291A1

    公开(公告)日：2009-01-29

    申请号：US12175803

    申请日：2008-07-18

    申请人： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

    发明人： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

    IPC分类号： A61B5/00

    CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/076 ,  Y10T29/49016 ,  Y10T29/49069 ,  Y10T29/49071 ,  Y10T29/49073

    摘要： A wireless sensor for indicating a physical state within an environment includes a unitary housing defining a cavity. A structure located within the cavity of the housing has elements providing capacitance, the elements being arranged such that the distance and thereby the capacitance of the structure changes when a physical state of the environment changes. The structure has a resonant frequency based at least in part on the capacitance of the structure when in the presence of a fluctuating electromagnetic field. When the sensor is positioned within an environment and is subjected to a fluctuating electromagnetic field, the resonant frequency indicates the physical state of the environment.

    摘要翻译： 用于指示环境中的物理状态的无线传感器包括限定空腔的整体壳体。 位于壳体的腔内的结构具有提供电容的元件，该元件被布置成使得当环境的物理状态改变时，结构的距离以及由此的结构的电容改变。 当存在波动的电磁场时，该结构至少部分地基于结构的电容。 当传感器位于环境中并且经受波动的电磁场时，谐振频率表示环境的物理状态。

    Method of manufacturing an implantable wireless sensor
    4.
    发明申请
    Method of manufacturing an implantable wireless sensor 有权
    可植入无线传感器的制造方法

    公开(公告)号：US20060235310A1

    公开(公告)日：2006-10-19

    申请号：US11472905

    申请日：2006-06-22

    申请人： David O'Brien ,  Jason White ,  Michael Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

    发明人： David O'Brien ,  Jason White ,  Michael Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

    IPC分类号： A61B5/02

    CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/076 ,  Y10T29/49016 ,  Y10T29/49069 ,  Y10T29/49071 ,  Y10T29/49073

    摘要： In the disclosed method of manufacturing an implantable wireless sensor, a cavity is etched in one side of a first substrate. A conductive structureare formed on the base of the cavity. A second conductive structureare formed on a surface of a second substrate, and the two substrates are mutually imposed such that the two conductive plates and coils are disposed in opposed, spaced-apart relation. A laser is then used to cut away perimeter portions of the imposed substrates and simultaneously to heat bond the two substrates together such that the cavity in the first substrate is hermetically sealed.

    摘要翻译： 在所公开的制造可植入无线传感器的方法中，在第一衬底的一侧蚀刻空腔。 导电结构形成在空腔的底部。 在第二基板的表面上形成第二导电结构，并且相互施加两个基板，使得两个导电板和线圈以相对的间隔关系设置。 然后使用激光来切除所施加的基板的周边部分，同时将两个基板热结合在一起，使得第一基板中的空腔被气密密封。

    Helical stent with micro-latches
    6.
    发明授权
    Helical stent with micro-latches 有权
    螺旋支架带微型闩锁

    公开(公告)号：US07255710B2

    公开(公告)日：2007-08-14

    申请号：US10636323

    申请日：2003-08-06

    申请人： Jason White ,  David Stern ,  Mark Allen ,  David O'Brien

    发明人： Jason White ,  David Stern ,  Mark Allen ,  David O'Brien

    IPC分类号： A61F2/06

    CPC分类号： A61F2/88 ,  A61F2/90

    摘要： A stent constructed using elements containing micro-mechanical latching mechanisms is disclosed. The micro-mechanical latching elements allow sliding motion between two surfaces in one direction, and restrict sliding motion in the opposite direction. The micro-mechanical latch surface features are formed using microelectronic mechanical systems (MEMS) manufacturing methods. The male surface of the latching components contains an array of ridges or protrusions, and the receiving surface contains a matching array of recesses. The array of ridges or protrusions and the corresponding recesses have uniformly dissimilar slopes that result in a substantially greater frictional force in one direction than in the opposite direction. The separation distance between the two surfaces is such that the male latch surface is engaged with the receiving surface recesses in the low stress “locked” state, preventing motion in the undesired direction.

    摘要翻译： 公开了使用包含微机械闭锁机构的元件构造的支架。 微机械闭锁元件允许在一个方向上的两个表面之间的滑动运动，并且在相反方向上限制滑动运动。 使用微电子机械系统（MEMS）制造方法形成微机械闩锁表面特征。 闩锁部件的阳表面包含脊或突起的阵列，并且接收表面包含匹配的凹槽阵列。 脊或突起的阵列和相应的凹槽具有均匀不相似的斜面，其在一个方向上产生比在相反方向上显着更大的摩擦力。 两个表面之间的分隔距离使得阳锁闩表面在低应力“锁定”状态下与接收表面凹部接合，从而防止在不期望的方向上的运动。

    Method of manufacturing an implantable wireless sensor
    7.
    发明授权
    Method of manufacturing an implantable wireless sensor 有权
    可植入无线传感器的制造方法

    公开(公告)号：US07574792B2

    公开(公告)日：2009-08-18

    申请号：US11472905

    申请日：2006-06-22

    申请人： David O'Brien ,  Jason White ,  Michael Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

    发明人： David O'Brien ,  Jason White ,  Michael Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

    IPC分类号： H01F7/06

    CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/076 ,  Y10T29/49016 ,  Y10T29/49069 ,  Y10T29/49071 ,  Y10T29/49073

    摘要： In the disclosed method of manufacturing an implantable wireless sensor, a cavity is etched in one side of a first substrate. A conductive structure are formed on the base of the cavity. A second conductive structureare formed on a surface of a second substrate, and the two substrates are mutually imposed such that the two conductive plates and coils are disposed in opposed, spaced-apart relation. A laser is then used to cut away perimeter portions of the imposed substrates and simultaneously to heat bond the two substrates together such that the cavity in the first substrate is hermetically sealed.

    摘要翻译： 在所公开的制造可植入无线传感器的方法中，在第一衬底的一侧蚀刻空腔。 在空腔的基部上形成导电结构。 在第二基板的表面上形成第二导电结构，并且相互施加两个基板，使得两个导电板和线圈以相对的间隔关系设置。 然后使用激光来切除所施加的基板的周边部分，同时将两个基板热结合在一起，使得第一基板中的空腔被气密密封。

    Hermetic chamber with electrical feedthroughs
    9.
    发明申请
    Hermetic chamber with electrical feedthroughs 有权
    具有电馈通的气密室

    公开(公告)号：US20070107524A1

    公开(公告)日：2007-05-17

    申请号：US11582669

    申请日：2006-10-18

    申请人： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Yeun-Ho Joung ,  Mark Allen

    发明人： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Yeun-Ho Joung ,  Mark Allen

    IPC分类号： G01L9/00

    CPC分类号： G01L9/0073

    摘要： An exemplary pressure cavity is disclosed that is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The exemplary pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from ambient pressure in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g., intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

    摘要翻译： 公开了一种示例性的压力腔，其是耐用的，稳定的和生物相容的并且以这样的方式配置，使得其构成微微至纳升级体积。 示例性压力腔与外部环境气密密封，同时保持与其他装置通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境压力密封，以减少传感器内的漂移和不稳定性。 传感器设计用于恶劣和生物环境，例如体内植入和体内使用。 另外，采用新的制造方法构造传感器。

    Hermetic chamber with electrical feedthroughs
    10.
    发明授权
    Hermetic chamber with electrical feedthroughs 有权
    具有电馈通的气密室

    公开(公告)号：US07748277B2

    公开(公告)日：2010-07-06

    申请号：US11582669

    申请日：2006-10-18

    申请人： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Yeun-Ho Joung ,  Mark Allen

    发明人： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Yeun-Ho Joung ,  Mark Allen

    IPC分类号： G01L9/00 ,  G01L9/12 ,  G01L9/06

    CPC分类号： G01L9/0073

    摘要： An exemplary pressure cavity is disclosed that is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The exemplary pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from ambient pressure in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g., intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

    摘要翻译： 公开了一种示例性的压力腔，其是耐用的，稳定的和生物相容的并且以这样的方式配置，使得其构成微微至纳升级体积。 示例性压力腔与外部环境气密密封，同时保持与其他装置通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境压力密封，以减少传感器内的漂移和不稳定性。 传感器设计用于恶劣和生物环境，例如体内植入和体内使用。 另外，采用新的制造方法构造传感器。