公开(公告)号：USRE38590E1

公开(公告)日：2004-09-14

申请号：US09291307

申请日：1999-04-15

申请人： Toshifumi Sumiya

发明人： Toshifumi Sumiya

IPC分类号： A61B1818

CPC分类号： A61F9/008 ,  A61F9/00804 ,  A61F9/00814 ,  A61F9/00817 ,  A61F9/00819 ,  A61F9/009 ,  A61F2009/00872

摘要： An operation apparatus for ablating the cornea by laser beam and correcting ametropia of the eye comprising a diaphragm with variable aperture, which is disposed on the optical path along which the laser beam is irradiated on the cornea, a shading member for shading the aperture of the diaphragm in the meridian diameter direction of the aperture, which is capable of varying the shading area to the aperture of the diaphragm by changing the turning angle to the optical path, in which aperture diameter of the diaphragm and variation in scope of the shading area by the shading member being controlled, and a beam rotator disposed in the eye side to the diaphragm rotates the laser beam passed through the aperture of the diaphragm about the optical path, whereby the cornea is ablated thicker at the periphery than at the center so as to correct hypermetropia.

公开(公告)号：US20040145702A1

公开(公告)日：2004-07-29

申请号：US10726733

申请日：2003-12-02

申请人： VISX, Incorporated

发明人： Junzhong Liang

IPC分类号： A61B003/00

CPC分类号： A61B3/1015 ,  A61F9/00806 ,  A61F9/00812 ,  A61F9/00819 ,  A61F2009/00842 ,  A61F2009/00848 ,  A61F2009/00853 ,  A61F2009/00872 ,  A61F2009/00897

摘要： A method for determining a refractive correction for an eye involves measuring an optical error of the eye, calculating at least one image quality parameter for a selected spatial frequency of range of spatial frequencies, based on the measured optical error of the eye, and forming a plan for refractive correction of the optical error, based on the calculated image quality parometer. In some embodiments, measuring the optical error involves taking one or more wavefront measurements. In some embodiments, calculating the parameter involves calculation a modulation transfer function.

摘要翻译： 用于确定眼睛的屈光矫正的方法包括测量眼睛的光学误差，基于所测量的眼睛的光学误差来计算空间频率范围的所选空间频率的至少一个图像质量参数，并且形成 根据计算出的图像质量计数器计算光学误差的折射校正。 在一些实施例中，测量光学误差包括进行一个或多个波前测量。 在一些实施例中，计算参数包括计算调制传递函数。

公开(公告)号：US06669342B2

公开(公告)日：2003-12-30

申请号：US10154412

申请日：2002-05-22

申请人： David M. Lieberman ,  Jonathon Grierson

发明人： David M. Lieberman ,  Jonathon Grierson

IPC分类号： A61B310

CPC分类号： A61F9/009 ,  A61F9/00804 ,  A61F9/00819 ,  A61F9/013 ,  A61F2009/00872 ,  A61F2009/00882

摘要： Methods, and apparatus are disclosed for performing corneal ablation procedures of the eye (12) in a manner which does not interfere with the natural shape of the cornea or its orientation relative to the remainder of the eye, but which changes its surface curvature appropriately to achieve the required correction of vision. Three preferred embodiments are described, which model the cornea to different degrees of accuracy. Once the model of the cornea is obtained (610, 620, 630), surface curvature is modified (650) to achieve the degree of correction in refraction that is necessary, as determined by an eye test of the patient. The modified model of the cornea is then utilized to control the removal of material from the surface of the cornea in a corneal ablation operation.

公开(公告)号：US06599285B1

公开(公告)日：2003-07-29

申请号：US09634336

申请日：2000-08-08

申请人： David Lieberman ,  Jonathan Grierson

发明人： David Lieberman ,  Jonathan Grierson

IPC分类号： A61B1732

CPC分类号： A61F9/013 ,  A61B34/10 ,  A61F9/00804 ,  A61F9/00819 ,  A61F2009/00872 ,  A61F2009/00882

摘要： Methods and apparatus are disclosed for causing the optical center of the eye to align “HIGH point” of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a “bounded region.” For corneal ablation procedures, the “bounded region” comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a “great circle” are formed in the cornea to weaken and flatten it. As used herein, a “great circle” is formed by a plane containing the HIGH point and parallel to the local z-axis. The “bounded region” for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis.

摘要翻译： 公开了使眼睛的光学中心对准角膜前表面的“高点”的方法和装置。 根据涉及角膜消融过程的本发明的一个方面，眼睛的高点被用作球形表面的极点，该球形表面近似地装配在“有界区域”内的角膜前表面的一部分上。 对于角膜消融程序，“有界区域”包括眼睛前表面的大致倒杯状的区域，其边缘在其周边被基本上垂直于局部z轴的平面限定。 在操作过程中，突出高于球面的局部高点被消融。 根据本发明涉及径向角膜切开手术的另一方面，在角膜中形成“大圆”平面中的一对切口，以削弱和平坦化。 如本文所使用的，“大圆”由包含HIGH点并平行于局部z轴的平面形成。 用于径向角膜切开术的“有界区域”绝对按照投射到角膜表面上的圆定义，该圆周围绕穿过高分辨率点并平行于z轴的轴线居中。

公开(公告)号：US20030093066A1

公开(公告)日：2003-05-15

申请号：US09949085

申请日：2001-09-10

发明人： Gholam A. Peyman

IPC分类号： A61B018/20

CPC分类号： A61F2/145 ,  A61F2/1451 ,  A61F9/00812 ,  A61F9/00819 ,  A61F9/013 ,  A61F2009/00872 ,  A61F2009/0088

摘要： A method of correcting the refractive error in a cornea of an eye, including forming a flap in the surface of the cornea, and moving the flap to expose first and second internal surfaces of the cornea. An implant is positioned adjacent the first internal surface, at least a portion of the implant having refractive properties and held adjacent the first internal surface using a tool. At least a portion of the implant is ablated with a light emitting device, when the implant is positioned on the first exposed surface of the cornea and being held by the instrument. The flap is then repositioned over the implant.

摘要翻译： 一种校正眼睛角膜中的折射误差的方法，包括在角膜表面形成瓣片，以及移动瓣片以暴露角膜的第一和第二内表面。 植入物定位成邻近第一内表面，植入物的至少一部分具有折射性质并且使用工具保持在第一内表面附近。 当植入物定位在角膜的第一暴露表面上并由仪器保持时，用发光器件消融植入物的至少一部分。 然后将瓣片重新定位在植入物上。

公开(公告)号：US06280470B1

公开(公告)日：2001-08-28

申请号：US09260571

申请日：1999-03-02

申请人： Gholam A. Peyman

发明人： Gholam A. Peyman

IPC分类号： A61F214

CPC分类号： A61F2/147 ,  A61F9/00804 ,  A61F9/00812 ,  A61F9/00817 ,  A61F9/00819 ,  A61F9/00821 ,  A61F9/013 ,  A61F2009/00872

摘要： A method for modifying the curvature of a live cornea to correct a patient's vision. First, at least one relatively small opening is made in the cornea for inserting a fiber optic cable or micro-cutting tool therein to create a pocket or cavity with first and second opposed internal surfaces. The laser beam or micro-cutting tool can be directed onto one of the first and second internal surfaces, or both, if needed or desired to incrementally and sequentially ablate or remove three-dimensional portions of the cornea. If a laser beam is used, then a flexible template can be inserted into the opening in the cornea for accurately controlling the pattern to be ablated within the cornea. Preferably, the live cornea is then left alone to collapse and obtain its new refractive power by waiting a set period of time. After waiting the set period of time, the cornea is then examined to determine the new refractive power of the cornea. Now, ocular material can be introduced to the cornea to further modify the curvature of the cornea as needed. The ocular material can be either a fluid or a solid lens, such as an annularly-shaped lens having an opening therein, or a combination of fluid and solid. In either case, the ocular material is transparent or translucent material with either a refractive index substantially the same as the intrastromal tissue of the cornea, or a different refractive index from the intrastromal tissue of the cornea.

摘要翻译： 用于修改活角膜的曲率以校正患者视力的方法。 首先，在角膜中形成至少一个相对较小的开口，用于将光缆或微型切割工具插入其中以形成具有第一和第二相对的内表面的袋或腔。 如果需要或期望激光束或微切割工具可以被引导到第一和第二内表面之一或两者，以逐渐地和顺序地消融或去除角膜的三维部分。 如果使用激光束，则可以将柔性模板插入到角膜的开口中，以精确地控制在角膜内消融的图案。 优选地，将活角膜单独地折叠并通过等待设定的时间段来获得其新的屈光力。 在等待设定的时间段后，然后检查角膜以确定角膜的新屈光力。 现在，可将眼部材料引入角膜，以进一步根据需要修改角膜的曲率。 眼部材料可以是流体或实心透镜，例如其中具有开口的环形透镜，或流体和固体的组合。 在任一种情况下，眼部材料都是透明或半透明的材料，其折射率与角膜的体内组织基本相同，或者与角膜的基质内组织不同的折射率。

公开(公告)号：US6063072A

公开(公告)日：2000-05-16

申请号：US818948

申请日：1997-03-17

申请人： David F. Muller

发明人： David F. Muller

IPC分类号： A61B18/20 ,  A61F9/007 ,  A61F9/01 ,  B23K26/073 ,  G02B3/04 ,  A61N5/06

CPC分类号： A61F9/008 ,  A61F9/00804 ,  A61F9/0081 ,  A61F9/00819 ,  B23K26/0734 ,  G02B3/04 ,  A61F2009/00844 ,  A61F2009/00872 ,  A61F9/00817

摘要： Methods and apparatus for corneal reprofiling are disclosed in which a beam-swapping assembly is employed to redirect rays of ablative radiation passing through the assembly. Essentially, the beam-swapping assembly turns the beam profile "inside out" redirecting the inner most rays to the periphery of the beam while redirecting the outer rays at the same time to the center of the beam. The beam-swapping assembly can be used in conjunction with a beam-shaper, such as an adjustable iris or other beam-shaping device, to create convoluted annular ablation patterns of variable depth and, thereby, perform hyperopia and/or astigmatism correcting procedures.

摘要翻译： 公开了用于角膜再生的方法和装置，其中使用束交换组件来重新定向穿过组件的消融辐射。 基本上，光束交换组件将光束轮廓“内向外”将最内侧的光线重定向到光束的周边，同时将外部光线同时重定向到光束的中心。 光束交换组件可以与光束整形器（诸如可调节光圈或其他光束整形装置）一起使用，以产生可变深度的旋转环形消融图案，从而执行远视和/或散光校正程序。

公开(公告)号：US5861486A

公开(公告)日：1999-01-19

申请号：US602922

申请日：1996-02-16

申请人： Dale P. Devore ,  Richard A. Eiferman

发明人： Dale P. Devore ,  Richard A. Eiferman

IPC分类号： A61F9/008 ,  A61F9/01 ,  A61L26/00 ,  A61L31/04 ,  C07K14/78 ,  C08H1/06 ,  C08L89/06 ,  A61K38/17 ,  A61K38/39

CPC分类号： C08H1/06 ,  A61F9/00819 ,  A61L26/0033 ,  A61L31/044 ,  C07K14/78 ,  C08L89/06 ,  A61F2009/00872 ,  A61F9/00804

摘要： A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative eximer laser keratectomy is provided. Collagen compositions for use in making collagen modulators useful in photoablative procedures are described. These compositions are applied to irregular corneal surfaces in sufficient amounts to at least fill in depressions or other irregularities on a corneal surface and are converted into a modulator, as a gel or polymerized film, prior to photoablation. The collagen modulators facilitate the photoablative smoothing of irregular corneal surfaces and protect adjacent corneal tissue from undesired photoablation.

摘要翻译： 提供了一种通过光烧伤激光角膜切除术来平滑不规则角膜表面和从角膜表面去除突起的方法。 描述了用于制备用于光蚀刻程序的胶原调节剂的胶原组合物。 将这些组合物以足够的量应用于不规则的角膜表面，至少填充角膜表面上的凹陷或其它不规则物，并在光消除之前转化为调制剂，作为凝胶或聚合膜。 胶原调节剂促进不规则角膜表面的光蚀刻平滑，并保护邻近角膜组织免受不希望的光消融。

公开(公告)号：US5807381A

公开(公告)日：1998-09-15

申请号：US731344

申请日：1996-10-11

申请人： David Lieberman

发明人： David Lieberman

IPC分类号： A61B19/00 ,  A61F9/008 ,  A61F9/01 ,  A61F9/013 ,  A61B17/32 ,  A61N5/06

CPC分类号： A61F9/013 ,  A61F9/00804 ,  A61F9/00819 ,  A61B34/10 ,  A61F2009/00872 ,  A61F2009/00882

摘要： Methods and apparatus are disclosed for causing the optical center of the eye to align "HIGH point" of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a "bounded region." For corneal ablation procedures, the "bounded region" comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a "great circle" are formed in the cornea to weaken and flatten it. As used herein, a "great circle" is formed by a plane containing the HIGH point and parallel to the local z-axis. The "bounded region" for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis.

公开(公告)号：US5740815A

公开(公告)日：1998-04-21

申请号：US476449

申请日：1995-06-07

申请人： Noel A. Alpins

发明人： Noel A. Alpins

IPC分类号： A61F9/007 ,  A61F9/01 ,  A61B19/00

CPC分类号： A61F9/008 ,  A61F9/00804 ,  A61F2009/00872 ,  A61F2009/00882 ,  A61F9/00817 ,  A61F9/00819

摘要： A method of surgically treating an eye of a patient to correct astigmatism in which values of astigmatism are measured topographically and refractively, and limit values of targeted induced astigmatism for the topographically and refractively measured astigmatism values are obtained by summating the topographically value of astigmatism with the refractive value of astigmatism and vice versa. Respective target values of astigmatism for refraction and topography based on the limit values are obtained and surgical treatment is effected with a target induced astigmatism which is intermediate the limit values and provided respective topographical and refractive non-zero target astigmatism values whose sum is a minimum.